Selective Serotonin Reuptake Inhibitors and Intracranial Hemorrhage

Background: Selective serotonin reuptake inhibitors (SSRIs) use may be associated with development of subdural hematoma (SDH). Objectives:To estimate SDH risk associated with antidepressant use, including when combined with antithrombotics, or nonsteroidal anti-inflammatory drugs (NSAIDs). Patients/Methods:We performed this case-control study based on Danish registries.We included 10 885 incident cases of SDH and 435 379 matched general population controls. We calculated odds ratios (95% confidence interval) adjusted for comorbidity, co-medication, education level, and income (aOR). Results:We found that current use of ) and non-SSRIs ) was associated with a higher SDH risk, compared with nonuse of antidepressants. Risks were higher with short duration of current use (eg,

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Selective Serotonin Reuptake Inhibitors and Intracranial Hemorrhage

Cited by 2 publications

References 12 publications

Antidepressants and the Risk of Ischemic Stroke in Older Adults According to the Degree of Serotonin Reuptake Inhibition: A Retrospective Cohort Study

Antidepressants and the Risk of Ischemic Stroke in Older Adults According to the Degree of Serotonin Reuptake Inhibition: A Retrospective Cohort Study

Antidepressant drug use and subdural hematoma risk

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