Selective serotonin reuptake inhibitors (SSRIs) for stroke recovery

The Usefulness and Clinical Characteristics of Antidepressant Use for Stroke Patients with Rehabilitation Program: An Exploratory Analysis

“…However, AD treatment has also many risk to develop undesirable adverse events, especially for comorbid medical illnesses such as stroke, which may limit active use of ADs by treating physician of rehabilitation program. Indeed treatment guidelines and large scale data analyses also suggest not to use ADs for stroke patients as blind or preventive way for better clinical outcomes concerning PSD, ADL, physical independence, and motor improvement [5,6].…”

“…The mainstay of potential effect of AD on rehabilitation in patients with stroke may be originated from their action mechanism in relation with the regulation of neuroinflamation, cerebral blood flow, cortical excitation/inhibition, neutotrophic factors, neuronal cell growth leading to neuronal regeneration [1]. However, currently existing evidence is still in a dearth of supporting the use of ADs for prevention of post-stroke depression (PSD) or improvement of motor recovery as proposed by recent treatment guidelines and meta-analysis [5,6].…”

Do Selective Serotonin Reuptake Inhibitors (SSRIs) Promote Stroke Recovery within the First Year After Stroke? ‐ A Cochrane Review Summary with Commentary

“…The strength of this Cochrane Review is that its primary analyses were based on data from trials at low risk of bias with a substantial number of participants providing a valid, clinically speaking clear estimate of no therapeutic effect on disability indicating that SSRIs prescribed for stroke survivors within the first year after stroke did not reduce disability or dependence.…”

“…Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are widely used to treat mood disorders (depression, anxiety) and had been shown to have a potential to promote recovery after stroke in a first Cochrane Review on the subject in 2012 . Meanwhile, more substantial clinical trial evidence became available warranting an update of the Cochrane Review …”

“…The aim of this commentary is to discuss in a rehabilitation perspective the Cochrane Review “https://doi.org/10.1002/14651858.CD009286.pub3” produced by Legg LA, Tilney R, Hsieh CF, Wu S, Lundström E, Rudberg AS, Kutlubaev MA, Dennis M, Soleimani B, Barugh A, Hackett ML, Hankey GJ, Mead GE https://doi.org/10.1002/14651858.CD009, and published by the Cochrane Stroke Group. This Cochrane Corner is produced in agreement with PM&R: The Journal of Injury , Function , and Rehabilitation by Cochrane Rehabilitation.…”