Selective Single-Molecule Nanopore Detection of mpox A29 Protein Directly in Biofluids

Cai, Shenglin; Ren, Ren; He, Jiaxuan; Wang, Xiaoyi; Zhang, Zheng; Luo, Zhaofeng; Tan, Weihong; Korchev, Yuri; Edel, Joshua B.; Ivanov, Aleksandar P.

doi:10.1021/acs.nanolett.3c02709

Cited by 7 publications

(2 citation statements)

References 52 publications

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“…Iontronic sensing on the basis of confined ion transport has emerged as an effective platform for analyzing single molecules using the principle of RPS. The RPS mechanism allows the detection of single molecules, such as ions/molecules, , and macromolecules like DNA/RNA/proteins, ,− with extraordinary sensitivity, enabling the extraction of their structural information. As single-molecule detection methods gain increasing importance in diagnostic applications, iontronics play a significant role in advancing the capabilities of single-molecule sensing.…”

Section: Applications Of Iontronic Sensors Based On Confined Ion Tran...mentioning

confidence: 99%

Iontronic Sensing Based on Confined Ion Transport

Ahmed,

Liu,

Xiong

et al. 2024

Anal. Chem.

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research field of iontronic sensors on the basis of confined ion transport represents a promising interdisciplinary domain that weaves together disciplines such as chemistry, physics, biology, material sciences, electrical engineering, and computer sciences. The advancement of this field stands to benefit from progress across these areas, while the flourishing of these disciplines, in turn, would facilitate the growth of sensors.

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Section: Applications Of Iontronic Sensors Based On Confined Ion Tran...mentioning

confidence: 99%

Iontronic Sensing Based on Confined Ion Transport

Ahmed,

Liu,

Xiong

et al. 2024

Anal. Chem.

View full text Add to dashboard Cite

show abstract

“…4 Since its discovery in 1996, this methodology has been extensively utilized for the characterization and detection of single molecules and DNA, as well as for protein sequencing applications. [5][6][7][8][9] An alternative paradigm involves using current-voltage (I-V) measurements in nanopores that display ion current rectification (ICR). 10,11 ICR refers to the non-ohmic I-V response exhibited by asymmetric nanopores, where the current magnitudes measured at equal but opposite potentials differ.…”

Section: Introductionmentioning

confidence: 99%