Selective sparing of later‐born ganglion cells after neonatal transection of the infraorbital nerve

White, Fletcher A.; Chiaia, Nicolas L.; McCann, Patricia; Enfiejian, Howard L.; MacDonald, Gordon J. F.; Bennett‐Clarke, Carol A.; Rhoades, Robert W.

doi:10.1002/cne.903310207

Cited by 5 publications

(2 citation statements)

References 40 publications

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“…In contrast, White et al (1990) observed that neonatal ION transection resulted in a marked decrease in the relative percentage of a nearly mutually exclusive population of V ganglion cells that bound the lectin Bandierea simplicifolia-I (BS-I). More recently, White et al (1993a) reported a significant relationship between V ganglion cell birth date and survival after neonatal axonal damage. They noted that V ganglion cells born late in gestation, on E-12.5 through E-14.5, were significantly more likely than early-born (E-9.5 through E-11.5) cells to survive neonatal axotomy.…”

Section: Indexing Terms: Neurogenesis Cell Death Immunocytochemistrmentioning

confidence: 99%

“…[3H]thymidine labelling combined with immunocytochemistry or histochemistry. Two sweeps were made across each section, and each immunoreactive or histochemically positive cell was evaluated for the presence of silver grains indicative of L3Hlthymidine labelling according to the criteria described by Sidman (1970) and Rakic (1973; see also White et al, 1993a). This process was continued until at least 1,000 immunoreactive neurons were evaluated.…”

Section: Percentages O F Nf- Cgrp- Sp- and Bs-i-positive Cells In mentioning

confidence: 99%

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Birth dates and survival after axotomy of neurochemically defined subsets of trigeminal ganglion cells

White

Chiaia

MacDonald

et al. 1995

J of Comparative Neurology

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Trigeminal (V) ganglion cells with different neurochemical phenotypes or different birth dates are affected differently by neonatal axonal transection. The aim of the present study was to determine if V ganglion cell birth date and neurochemical phenotype were correlated and if these two variables could be related to responses to neonatal axonal transection. Immunocytochemistry, histochemistry, and [3H]thymidine labelling were used to determine the birth dates of V ganglion cells recognized by antibodies directed against neurofilament protein (NF), calcitonin gene-related peptide (CGRP), and substance P (SP) and those that bound the lectin Bandierea simplicifolia-I (BS-I). All V ganglion cells were born between embryonic days (E-) 9.5 and 14.5. All ganglion cells were born between E-9.5 and E-14.5. In a normalized population (percentages normalized to equal 100%), over 90% of NF-positive V ganglion cells were born between E-10.5 and E-12.5. The majority of CGRP-positive and SP-positive ganglion cells (> 90%) were generated from E-13.5 to E-14.5 and E-12.5 through E-14.5, respectively. Almost 85% of BS-I-positive ganglion cells were generated on E-12.5 through E-14.5. Previous results and additional data from this study indicated that NF- and BS-I-positive ganglion cells are proportionally more likely to be lost after neonatal axotomy and that SP-positive cells are more likely to remain. The percentage of CGRP-positive cells in the V ganglion was not significantly altered by neonatal infraorbital nerve transection. Overall, these findings do not indicate a strong relationship between cell birth date and the probability of survival after neonatal axonal damage for all V ganglion cell phenotypes.

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Section: Indexing Terms: Neurogenesis Cell Death Immunocytochemistrmentioning

confidence: 99%

Section: Percentages O F Nf- Cgrp- Sp- and Bs-i-positive Cells In mentioning

confidence: 99%

Birth dates and survival after axotomy of neurochemically defined subsets of trigeminal ganglion cells

White

Chiaia

MacDonald

et al. 1995

J of Comparative Neurology

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Neonatal damage to the rat's infraorbital nerve upregulates both galanin and neuropeptide Y in individual vibrissae-related primary afferent axons

et al. 1996

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Previous studies in adult animals have suggested that the peptides galanin and neuropeptide Y (NPY) may be upregulated in the same primary afferent neurons after peripheral axotomy. The present study was undertaken to determine whether such upregulation occurred in vibrissae-related primary afferent neurons and their axons after damage to the infraorbital nerve [ION; the trigeminal (V) branch that innervates the vibrissae follicles]. Double-labelling experiments demonstrated that approximately 75% of axotomized V ganglion cells and the central arbors of vibrissae-related primary afferents expressed both galanin and NPY after perinatal, but not adult, nerve damage. However, additional experiments demonstrated that the sensitive periods for lesion-induced upregulation of the two peptides and the period over which they were expressed after neonatal ION transection differed substantially. Staining for both peptides was increased after ION damage on P-0 through P-14, but only galanin staining was increased in vibrissae-related primary afferents after lesions on P-21. Galanin expression was elevated in vibrissae-related primary afferents in rats killed 3, 8, and 15 days after neonatal ION transection, while increased NPY was observed at only the middle time point. The lesion-induced increases in galanin and NPY in vibrissae-related ION primary afferents suggest that these peptides may modulate central V reorganization after such damage.

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Organization, development, and effects of infraorbital nerve transection on galanin binding sites in the trigeminal brainstem complex

Bodie

Bennett‐Clarke²,

Davis³

et al. 1997

Somatosensory & Motor Research

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Previous experiments from this laboratory have indicated that transection of the infraorbital nerve (ION, the trigeminal [V] branch that supplies the mystacial vibrissae follicles) at birth and in adulthood has markedly different effects on galanin immunoreactivity in the V brainstem complex. Adult nerve transection increases galanin immunoreactivity in the superficial layers of V subnucleus caudalis (SpC) only, while neonatal nerve transection results in increased galanin expression in vibrissae-related primary afferents throughout the V brainstem complex. The present study describes the distribution of binding sites for this peptide in the mature and developing V ganglion and brainstem complex and determines the effects of neonatal and adult ION damage and the associated changes in galanin levels upon their distribution and density. Galanin binding sites are densely distributed in all V brainstem subnuclei and are particularly dense in V subnucleus interpolaris and the superficial layers of SpC. They are present at birth (P-0) and their distribution is similar to that in adult animals. Transection of the ION in adulthood and examination of brainstem 7 days later indicated marked reductions in the density of galanin binding sites in the V brainstem complex. With the exception of the superficial laminae of SpC, the same reduction in density remained apparent in rats that survived > 45 days after nerve cuts. Transection of the ION on P-0 resulted in no change in the density of galanin binding sites in the brainstem after either 7 or > 60 days survival. These results indicate that densely distributed galanin binding sites are present in the V brainstem complex of both neonatal and adult rats, that they are located in regions not innervated by galanin-positive axons, and that their density is not significantly influenced by large lesion-induced changes in the primary afferent content of their natural ligand.

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Selective sparing of later‐born ganglion cells after neonatal transection of the infraorbital nerve

Cited by 5 publications

References 40 publications

Birth dates and survival after axotomy of neurochemically defined subsets of trigeminal ganglion cells

Birth dates and survival after axotomy of neurochemically defined subsets of trigeminal ganglion cells

Neonatal damage to the rat's infraorbital nerve upregulates both galanin and neuropeptide Y in individual vibrissae-related primary afferent axons

Organization, development, and effects of infraorbital nerve transection on galanin binding sites in the trigeminal brainstem complex

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