Selective Susceptibility of Synovial Fibroblasts Isolated from Patients with Rheumatoid Arthritis to TRAIL-induced Cell Death

Regulation of GRB2 and FLICE2 expression by TNF-α in rheumatoid synovium

“…FLICE2 (caspase 10) has been known to interact with death-inducing signaling complex (DISC) of TNFR1, Fas, and TNF-related apoptosis-inducing ligand (TRAIL) [15,16]. Our results showing overexpression of FLICE2 in RA FLS might provide an interpretation by which RA FLS are more susceptible to TRAIL-and Fas-induced apoptosis than OA cells as reported previously [4,17].…”