Selective Syntheses of Planar-Chiral Ferrocenes

Abstract

Planar-chiral ferrocenes are widely applied in catalytic asymmetric transformations in scientific research as well as in industry. A plethora of different methodologies have been developed to access these molecules with a high degree of regio- and stereoselectivity. The aim of this contribution is to give a comprehensive overview of this topic. The synthesis of 1,2- and 1,3-substituted ferrocenes by electrophilic aromatic substitution, ortho-directed metalation, kinetic resolution, and desymmetrization is discussed. Advantages and disadvantages are highlighted.

Research Progress on the Synthesis and Application of Cyclopentadiene Derivatives

“…图式 10 二茂钌衍生物的合成 Scheme 10 Synthesis of ruthenocene derivatives 在众多方法中 [59,60] , 通过直接催化 C-H 键活化可 合成不同的茂金属配合物, 此方法是合成不对称金属茂 化合物有效的方法 [61] . 1997 先与环戊二烯发生 Diels-Alder 反应生成极不稳定的环 状过氧化中间产物, 此化合物在温度高于 0 ℃时即发 生 Claisen 重排转化成烯酮化合物(Scheme 11).…”

Ferrocene in agriculture: from agrochemicals and soil remediation to selective chemosensors

“…The success of Josiphos and its Xyliphos modification boosted both industrial applications of chiral catalysts [30][31][32] and the synthesis of new chiral ferrocenes [33][34][35][36][37] as well as their use in asymmetric synthesis [38][39][40][41][42]. Thus, the first Josiphos was the parent compound for a family of effective chiral ligands that found application in enantioselective synthesis of other compounds useful in agriculture.…”

Rhodium‐Catalyzed Enantioselective Intramolecular CH Silylation for the Syntheses of Planar‐Chiral Metallocene Siloles

“…[1, 2] Among many existing methods, [3,4] catalytic direct C À Hbond activation has emerged as am ore efficient strategy for the asymmetric syntheses of metallocenes. [5] In 1997, the group of Schmalz disclosed ac opper-catalyzed enantioselective intramolecular carbene insertion into C À Hb onds of the cyclopentadiene (Cp) ring in ferrocenes.…”