Several β-N-glycosides were obtained upon a simple and efficient two-step methodology. First, α-1,2-anhydrosugars were prepared diastereoselectively by the oxidation of 3,4,6-tri-O-benzyl-D-glucal under biphasic conditions (CH 2 Cl 2 /water) using dimetyldioxirane (DMDO) generated in situ from oxone/ acetone mixture and amphiphilic imidazolium ionic liquid (DodMImBF 4 ) as phase transfer catalyst. Immediately, β-Nglycosides were synthesized in good yields by aminolysis of these α-1,2-anhydrosugars using CH 3 CN as solvent. The overall process allows stereoselective generation of biologically relevant carbohydrate derivatives.
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