Selective therapeutic benefit of X-rays and inhibitors of EGFR, PI3K/mTOR, and Bcl-2 in breast, lung, and cervical cancer cells

Hamid, Mogammad; Serafin, Antonio; Akudugu, John

doi:10.1016/j.ejphar.2021.174612

Cited by 2 publications

(1 citation statement)

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“…PI3K/Akt/mTOR signaling pathway activation promotes tumorigenesis of cervical carcinoma, thus inhibiting this pathway may be a strategy for targeting therapies [19]. Furthermore, a recent study shows that HeLa cell line was more sensitive to Dactolisib compared to other key pathway inhibitors, suggesting that this PI3K/mTOR inhibitor therapy may be a potential benefit to cervical cancer patient [20].…”

Section: Introductionmentioning

confidence: 99%

The Anti-proliferative Effect of Caffeic Acid and Dactolisib on Human Cervical Carcinoma HeLa Cell Line

Bolat

2024

Cumhuriyet Science Journal

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Cervical carcinoma is a common gynecological cancer with high mortality rate among women worldwide. Caffeic acid exerts an antiproliferative effect against cervical carcinoma. Dactolisib is a dual PI3K and mTOR inhibitor that has a therapeutic potential for cervical carcinoma. This study aimed to reveal the anti-proliferative effect of combination treatment of caffeic acid and Dactolisib on cervical carcinoma HeLa cell line. Cytotoxicity of caffeic acid and Dactolisib on HeLa cell line was assessed by MTS assay. Colony formation of HeLa cells treated with caffeic acid and Dactolisib was determined by staining colonies with crystal violet and visualizing under light microscope. Dactolisib decreased cell proliferation of HeLa cells in time and dose dependent manner. 5 μM caffeic acid did not show any significant change in cell viability of HeLa cells. Combination treatment of 5 μM caffeic acid and 0.5 μM Dactolisib showed decrease in cell viability of HeLa cells when compared to Dactolisib treated cells. Combination of caffeic acid and Dactolisib decreased colony diameter of HeLa cells significantly when compared to control group. Caffeic acid and Dactolisib shows anti-proliferative effect on human cervical carcinoma HeLa cell line, so further studies should be performed to reveal the mechanism of action.

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Section: Introductionmentioning

confidence: 99%