Selective transduction of astrocytic and neuronal CNS subpopulations by lentiviral vectors pseudotyped with Chikungunya virus envelope

Abstract

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Pseudotyped Lentiviral Vectors: One Vector, Many Guises

“…Interestingly, transduction of monocytic THP1 cells enhances significantly upon their differentiation into macrophages. 78,79 This is possibly due to enhanced expression of viral receptors on their surface. Unlike RRV-LVs, WEEVLVs and VEEV-LVs show much lower titers when pseudotyped.…”

Is Viral Vector Gene Delivery More Effective Using Biomaterials?

“…A variety of techniques has been investigated to engineer the viral vector capsid or envelope, including adaptors for vector targeting, genetic insertion of receptor targeting ligands, hybrid vectors with mosaic/chimeric vectors to achieve the properties of multiple serotypes, and pseudotyping. [53,[272][273][274]…”

The medicinal chemistry of Chikungunya virus

“…38,39 In general, CHIKV attacks fibroblasts, suggesting its involvement with muscles, joints, and skin connective tissues. 7,8,12,25,31 Despite the propagation and the high morbidity rate of CHIKV infections, there is currently no approved vaccine or antiviral treatment available. 40 Although, physical exercise are recommended to decrease the joint stiffness.…”

“…2 Mosquitos (Diptera: Culididae) are vectors of pathogens and parasites of health diseases, such as dengue, zika, Chikungunya and lymphatic filariasis. [4][5][6][7][8][9][10][11] It is transmitted by the bite of female mosquitoes of the Aedes aegypti, A. albopictus, A. furcifer species 12 and Culex ssp. 3 .…”