Selective Transport of IgGl into the Mammary Gland: Role of Estrogen and Progesterone

Smith, Kenneth L.; Muir, Larry A.; Ferguson, L C; Conrad, H.R.

doi:10.3168/jds.s0022-0302(71)86130-1

Cited by 58 publications

(16 citation statements)

References 20 publications

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“…Indeed, the decrease in plasma IgG occurred when plasma P4 concentrations were still high. Moreover, P4 was shown to prevent closure of tight junctions between lactocytes in the mouse [10,11] and, when associated with E2, to enable paracellular transfer of immunoglobulins from plasma to the alveolar lumen of mammary glands in the cow [41]. In sows, Jackson et al [42] confirmed the positive role of P4 on IgG transfer by showing higher colostrum concentrations of IgG in sows treated with P4 and farrowing at 116 days of gestation instead of 114 days.…”

Section: Plasma Hormones Lactose and Igg Variations Around Parturitionsupporting

confidence: 59%

Hormones, IgG and lactose changes around parturition in plasma, and colostrum or saliva of multiparous sows

et al. 2004

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-Blood, colostrum and saliva samples were serially taken from 6 multiparous sows from day 109 of gestation until day 3 postpartum. Plasma was assayed for oestradiol-17β (E2), progesterone (P4), prolactin (PRL), cortisol, immunoglobulin G (IgG) and lactose. Colostrum was assayed for E2, P4, IgG and lactose. Lactoserum, obtained after ultra centrifugation of colostrum, was assayed for PRL. Saliva was assayed for cortisol. Time-related variations in hormone, IgG and lactose concentrations measured in plasma were parallel to those measured in colostrum, lactoserum or saliva. However, the concentrations were higher in colostrum or lactoserum and lower in saliva than in plasma. Ratios of concentrations of cortisol in saliva and PRL in lactoserum over those in plasma did not vary with time and averaged 0.2 and 1.6, respectively. Conversely, the ratios of concentrations of E2 and P4 in colostrum over those in plasma varied with time (P < 0.05) but were quite constant before the end of parturition, averaging 2.7 and 3.6, respectively. The ratios of concentrations of IgG and lactose in colostrum over those in plasma also varied with time (P < 0.05). The concentrations of hormones in plasma on the one hand and in colostrum, lactoserum or saliva on the other hand were significantly correlated but correlations varied with time (PRL across periods: r = 0.31; cortisol across periods: r = 0.60; E2 during parturition: r = 0.83; P4 before parturition: r = 0.82; P4 during parturition: r = 0.67). The present results indicate that around parturition, assays of hormones in colostrum or saliva can be used to study the hormonal status of sows. Furthermore, variations in colostrum and plasma concentrations of IgG and lactose are good indicators of the transition from colostrum to milk synthesis. sow / parturition / steroid / prolactin / lactose / immunoglobulins

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Section: Plasma Hormones Lactose and Igg Variations Around Parturitionsupporting

confidence: 59%

Hormones, IgG and lactose changes around parturition in plasma, and colostrum or saliva of multiparous sows

et al. 2004

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“…While not excluding the possibility of endocrine influences playing a direct role in the selective transfer of large amounts of Igd into colostrum, the above data support the notion that selective transfer of IgG, is a physiological characteristic of glandular epithelium and that its magnitude varies throughout lactation inversely with the synthetic activity of the cell. This interpretation apparently contradicts that of Smith and his colleagues (Smith et al 1971) who suggested that ovarian steroid hormones exert at least some control on selective transfer of IgGj. These conclusion were based on the results of experiments in which increases in selective transfer of IgGl were observed in non-pregnant, non-lactating cows following injection of ovarian steroids.…”

Section: Concentration Of Iggi In Secretionmentioning

confidence: 75%

Localized Humoral Immunity with Particular Reference to Ruminants

Lascelles

McDowell

1974

Immunological Reviews

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“…Marked changes in milk composition and yield have been reported following administration of estrogen to cows (13,31,34) and goats (25) and it was concluded that a hormonal mechanism is involved since the changes also occurred in mammary gland denervated and autotransplanted to the neck (25). Furthermore, similar changes in the composition of human milk were observed around ovulation when estradiol levels are high (15).…”

Section: Discussionmentioning

confidence: 98%

Influence of Exogenous Estradiol on the Concentration of Antitrypsin, Albumin, N‐Acetyl‐pβ‐D‐Glucosaminidase and Somatic Cells in Milk of Cows at Various Lactation Stages

Saad

Kaartinen

Aström

1990

Journal of Veterinary Medicine Series A

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Estradiol benzoate (0.02 mg/kg of body weight) was injected (i. m.) daily to 13 ovariectomized cows in their first or third lactations during early (60-90 days), mid (140-200 days) and late (240-300 days) lactation. The majority of the udder quarters were free of bacteria throughout the experiment. Signs of clinical mastitis were observed after 9-19 days of treatment in cows at mid and late lactation. This was accompanied by a decrease in milk yield, an increase in milk somatic cell count (MSCC) and increases in milk concentration of antitrypsin and serum albumin (as indicator of increased permeability); and milk NAGase activity (as indicator of epithelial cell damage or release of the enzyme from phagocytes). NAGase activity was first to increase and on some occasions was not accompanied by an increased MSCC. The response was either absent (first lactation) or relatively mild (third lactation) in cows at the early stages of lactation. The intensity of the inflammatory response increased with advancing lactation stage. Generally, the response of cows in the third lactation was greater than that of cows in the first lactation at a corresponding stage of lactation. Three cows which received the control treatment with vehicle alone showed no changes in any of the parameters except a slight decrease in antitrypsin. All inflammatory indicators correlated negatively with quarter milk production; milk NAGase activity was superior in this respect (r = -0.75). All correlation coefficients were generally higher after, rather than before the hormone treatment.

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Selective Transport of IgGl into the Mammary Gland: Role of Estrogen and Progesterone

Cited by 58 publications

References 20 publications

Hormones, IgG and lactose changes around parturition in plasma, and colostrum or saliva of multiparous sows

Hormones, IgG and lactose changes around parturition in plasma, and colostrum or saliva of multiparous sows

Localized Humoral Immunity with Particular Reference to Ruminants

Influence of Exogenous Estradiol on the Concentration of Antitrypsin, Albumin, N‐Acetyl‐pβ‐D‐Glucosaminidase and Somatic Cells in Milk of Cows at Various Lactation Stages

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