Selective treatment of neoplastic cells using ferritin-mediated electromagnetic hyperthermia

Babincová, Melánia; Leszczyńska, Danuta; Sourivong, P.; Babinec, Peter

doi:10.1054/mehy.1999.0011

Cited by 49 publications

(26 citation statements)

References 17 publications

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“…1 Therefore, SPIONs have gained wide clinical acceptance in diagnostic radiology practice because they cause inhomogeneous susceptibility in magnetic resonance imaging (MRI) and change the relaxometry curves. However, their therapeutic applications in drug delivery, cell labeling, and tissue engineering are still under investigation.…”

Section: Introductionmentioning

confidence: 99%

Metabolic pathway and distribution of superparamagnetic iron oxide nanoparticles: in vivo study

Schlachter

Widmer²,

Bregy³

et al. 2011

IJN

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Background: Experimental tissue fusion benefits from the selective heating of superparamagnetic iron oxide nanoparticles (SPIONs) under high frequency irradiation. However, the metabolic pathways of SPIONs for tissue fusion remain unknown. Hence, the goal of this in vivo study was to analyze the distribution of SPIONs in different organs by means of magnetic resonance imaging (MRI) and histological analysis after a SPION-containing patch implantation. Methods: SPION-containing patches were implanted in rats. Three animal groups were studied histologically over six months. Degradation assessment of the SPION-albumin patch was performed in vivo using MRI for iron content localization and biodistribution. Results: No SPION degradation or accumulation into the reticuloendothelial system was detected by MRI, MRI relaxometry, or histology, outside the area of the implantation patch. Concentrations from 0.01 µg/mL to 25 µg/mL were found to be hyperintense in T1-like gradient echo sequences. The best differentiation of concentrations was found in T2 relaxometry, susceptibility-sensitive gradient echo sequences, and in high repetition time T2 images. Qualitative and semiquantitative visualization of small concentrations and accumulation of SPIONs by MRI are feasible. In histological liver samples, Kupffer cells were significantly correlated with postimplantation time, but no differences were observed between sham-treated and induction/no induction groups. Transmission electron microscopy showed local uptake of SPIONs in macrophages and cells of the reticuloendothelial system. Apoptosis staining using caspase showed no increased toxicity compared with sham-treated tissue. Implanted SPION patches were relatively inert with slow, progressive local degradation over the six-month period. No distant structural alterations in the studied tissue could be observed. Conclusion: Systemic bioavailability may play a role in specific SPION implant toxicity and therefore the local degradation process is a further aspect to be assessed in future studies.

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Section: Introductionmentioning

confidence: 99%

Metabolic pathway and distribution of superparamagnetic iron oxide nanoparticles: in vivo study

Schlachter

Widmer²,

Bregy³

et al. 2011

IJN

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“…>1000mm 3 ) if there is proper regulation of the magnetic mass used and the intra-tumoural particle distribution [50]. The frequency should be greater than that sufficient to cause any neuromuscular response, and less than that capable of causing any detrimental heating of healthy tissue, ideally in the range of 100-1000 kHz [51,52]). If suitable frequencies and field strength combinations are used, no interaction is observed between the human body and the field.…”

Section: Thermotherapy or Hyperthermia Of Tumorsmentioning

confidence: 99%

“…If the metal is magnetic, such as iron, the phenomenon is greatly enhanced. Therefore, when a magnetic fluid is exposed to an alternating magnetic field the particles become powerful heat sources, destroying the tumour cells [51,52] (Figure 5). The proper disposal of dead tumor cells and magnetic particles is also equally important.…”

Section: Thermotherapy or Hyperthermia Of Tumorsmentioning

confidence: 99%

Size and Shape Effect on Biomedical Applications of Nanomaterials

Ankamwar¹

2012

Biomedical Engineering - Technical Applications in Medicine

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“…Babincova et al also reported dextran-magnetite has no measurable toxicity index LD50. 32,33 Fig .17 shows that the heating curves of Fe 3 O 4 particles with and without SiO 2 shell in the ac magnetic field with 43.1 mT and 72kHz. The average particle size is 30 nm and the shell thickness is about 10 nm.…”

Section: Magnetic Fluid Hyperthermia Behaviormentioning

confidence: 99%