Selective versus nonselective intraarterial chemoradiation for tonsil cancer

Naidu, Srikanth I.; Samant, Sandeep; Vieira, Francisco

doi:10.1016/s0194-5998(03)01032-5

Cited by 1 publication

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“…The results of the recent studies show that a combination of regional chemotherapy by intra-arterial infusion of high doses of cisplatin with radiation therapy could be a useful approach when planning integrated treatment for locally advanced head and neck cancer [9]. Intra-arterial chemotherapy seems to be a promising strategy in the therapy of untreated locally advanced head and neck cancer with concurrent radiotherapy due to advantages of high-dose delivery of drug, minimal procedural complications, low systemic toxicity, and high tumor response rate [10][11][12]. The objective of the present study was to evaluate the efficacy and safety of intra-arterial chemotherapy for palliation of tumor-related symptoms in patients with locally progressive, unresectable and previously irradiated head and neck cancer.…”

Section: Introductionmentioning

confidence: 99%

Selective High-Dose Intra-Arterial Cisplatin as Palliative Treatment for Incurable Head and Neck Cancer

Teymoortash¹,

Bien

Dalchow³

et al. 2004

Oncol Res Treat

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Objective: The purpose of the present study was to evaluate the palliative effect of selective intra-arterial chemotherapy in progressive unresectable head and neck cancer previously treated with radiochemotherapy. Patients and Methods: 8 patients with advanced residual or recurrent squamous cell carcinoma of the head and neck were evaluated. These patients were included in the present study particularly because of progredient pain and recurrent bleedings due to tumor progression. In addition 6/8 patients suffered from unpleasant tumor-related smell. All patients received simultaneous infusions of cisplatin (150 mg/m2) intra-arterially to the tumor and sodium thiosulfate intravenously (9 g/m2) for systemic neutralization of cisplatin. The patients were treated by at most 4 cycles of selective intra-arterial chemotherapy via femoral approach. Results: Tumor-associated pain, occurrence of tumor bleeding and tumor-related smell were reduced after at least 2 cycles of intra-arterial chemotherapy in all patients. Clinical and radiological assessment of the primary tumor site revealed a partial response in 4 patients while 4 patients were classified as nonresponders. Intra-arterial cisplatin treatment was well tolerated. Conclusion: Selective intra-arterial cisplatin therapy can be delivered safely for palliation of tumor-related symptoms of incurable head and neck cancer.

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Section: Introductionmentioning

confidence: 99%