Selective visible-light-driven toxicity breakdown of nerve agent simulant methyl paraoxon over a photoactive nanofabric

Filho, José Dias de Souza; Bruziquesi, Carlos Giovani Oliveira; Rios, Regiane D.F.; Castro, Alexandre A. de; Victória, Henrique F.V.; Mansur, Alexandra A.P.; Siniterra, Ruben D.; Ramalho, Teodorico C.; Pereira, Márcio C.; Oliveira, Luiz C.A.

doi:10.1016/j.apcatb.2020.119774

Cited by 16 publications

(8 citation statements)

References 47 publications

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“…e advantages of NbOFe-NF are the selectivity for the production of less toxic compounds in which it only cleaves the P-O-Ar system and the demethylation of DMPP by the nanofabric generates nontoxic compounds. is detoxifying process is wholly via photocatalysis, through h + and O • H [126].…”

Section: Future Directions In the Treatment Of Op Poisoningmentioning

confidence: 99%

Transitioning from Oxime to the Next Potential Organophosphorus Poisoning Therapy Using Enzymes

Mohamed

Ong

Kasim

et al. 2021

Journal of Chemistry

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For years, organophosphorus poisoning has been a major concern of health problems throughout the world. An estimated 200,000 acute pesticide poisoning deaths occur each year, many in developing countries. Apart from the agricultural pesticide poisoning, terrorists have used these organophosphorus compounds to attack civilian populations in some countries. Recent misuses of sarin in the Syrian conflict had been reported in 2018. Since the 1950s, the therapy to overcome this health problem is to utilize a reactivator to reactivate the inhibited acetylcholinesterase by these organophosphorus compounds. However, many questions remain unanswered regarding the efficacy and toxicity of this reactivator. Pralidoxime, MMB-4, TMB-4, obidoxime, and HI-6 are the examples of the established oximes, yet they are of insufficient effectiveness in some poisonings and only a limited spectrum of the different nerve agents and pesticides are being covered. Alternatively, an option in the treatment of organophosphorus poisoning that has been explored is through the use of enzyme therapy. Organophosphorus hydrolases are a group of enzymes that look promising for detoxifying organophosphorus compounds and have recently gained much interest. These enzymes have demonstrated remarkable protective and antidotal value against some different organophosphorus compounds in vivo in animal models. Apart from that, enzyme treatments have also been applied for decontamination purposes. In this review, the restrictions and obstacles in the therapeutic development of oximes, along with the new strategies to overcome the problems, are discussed. The emerging interest in enzyme treatment with its advantages and disadvantages is described as well.

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Section: Future Directions In the Treatment Of Op Poisoningmentioning

confidence: 99%

Transitioning from Oxime to the Next Potential Organophosphorus Poisoning Therapy Using Enzymes

Mohamed

Ong

Kasim

et al. 2021

Journal of Chemistry

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“…TiO2-based materials are more active, but suffer from the low surface area [38,39] and possible agglomeration leading to moderate recycling ability [38]. The last generation of semiconducting materials is one of the most promising [13,40], however, suggested here PET@UiO-66-Ag25 is overperforming them in terms of easiness of preparation, time to quantitative degradation, visible light usage and recycling performance (Table 2).…”

Section: Comparison With Other Materialsmentioning

confidence: 99%

Synergetic effect of metal-organic framework UiO-66 and silver plasmonic nanoparticles on PET waste support in degradation of nerve agent simulant

Semyonov

Kogolev

Trelin

et al. 2021

Preprint

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The combination of versatile metal-organic frameworks (MOFs) with high porosity and catalytic activity with plasmonic nanoparticles (PNPs) defines a new paradigm in photocatalytic degradation of ecotoxicants. Herein, we prepared a novel composite from a waste polyethylene terephthalate, MOF – UiO-66 and silver nanoparticles (AgNPs) for degradation of nerve agent simulant paraoxon-ethyl, where the additional plasmon excitation at 455 nm enhances Lewis’s acid activity of UiO-66. The obtained material was characterized by spectroscopic: XRD, UV-Vis, FT-IR, XPS, microscopic: SEM, TEM and ICP-MS and TGA. We found the balance between pore availability of UiO-66 for paraoxon-ethyl adsorption to Lewis sites, plasmonic enhancement, and cost minimization in optimal material through variation of added Ag precursor amounts PET@UiO-66-Ag25. Synergetic mechanisms enhanced the degradation rate by more than 3 times compared to PET@UiO-66 with the quantitative paraoxon degradation for 1 hour (>95 %) and >99 % for 2 hours. Moreover, the prepared material is overperforming other materials in terms of environmental impact, easiness of preparation, visible light usage, high apparent quantum yield and recycling performance.

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“…The normal level of alkaline phosphatase in human serum is 40–190 U/L for adults. , Alkaline phosphatase can cause a dephosphorylation reaction for nucleic acids, proteins, small molecules, and could be responsible for removal of the phosphate group of pesticides . Methyl paraoxon pesticides have been widely used in agriculture and could cause serious health problems for humans even at very low concentrations . To date, many methods such as colorimetric, capillary electrophoresis, electrochemiluminescence, surface plasmon resonance, and surface enhanced Raman scattering have been used for enzymatic detection of methyl paraoxon using materials such as carbon quantum dots, , gold nanoclusters, , MnO 2 nanosheets, and CdTe quantum dots .…”

Section: Introductionmentioning

confidence: 99%

Alkaline Phosphatase Immobilized CdTe/ZnS Quantum Dots for Dual-Purpose Fluorescent and Electrochemical Detection of Methyl Paraoxon

Dewangan

Korram

Karbhal

et al. 2022

Ind. Eng. Chem. Res.

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A facile paper-based fluorescence sensing and electrochemical behavior of CdTe/ZnS quantum dots (QDs) for detection of methyl paraoxon has been reported. The hydrolytic activity of alkaline phosphatase (ALP) for methyl paraoxon was observed to produce p-nitrophenol in the presence of QDs. The fluorescence quenching of CdTe/ZnS QDs by p-nitrophenol was measured as a quantitative signal for the detection of methyl paraoxon. A paper chip-based sensor has been developed by deposition of CdTe/ZnS QDs into cellulose paper. The significant increase in oxidation current in the cyclic voltammogram of methyl paraoxon solution in the presence of ALP is observed using a glassy carbon electrode (GCE) modified with CdTe/ZnS QDs. The linear relationship between oxidation and reduction peak currents against concentration of methyl paraoxon is utilized as a quantitative signal of electrochemical detection of methyl paraoxon. Under optimum conditions, both fluorescenceand paper-based methods showed a limit of detection (LOD) ≈ 0.65 nM whereas cyclic voltammetry provided a 2-fold higher LOD (1.72 nM) for sensing of methyl paraoxon. Therefore, the present method is a new insight for the rapid, convenient, and trace amount detection of methyl paraoxon.

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Selective visible-light-driven toxicity breakdown of nerve agent simulant methyl paraoxon over a photoactive nanofabric

Cited by 16 publications

References 47 publications

Transitioning from Oxime to the Next Potential Organophosphorus Poisoning Therapy Using Enzymes

Transitioning from Oxime to the Next Potential Organophosphorus Poisoning Therapy Using Enzymes

Synergetic effect of metal-organic framework UiO-66 and silver plasmonic nanoparticles on PET waste support in degradation of nerve agent simulant

Alkaline Phosphatase Immobilized CdTe/ZnS Quantum Dots for Dual-Purpose Fluorescent and Electrochemical Detection of Methyl Paraoxon

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