Selectively attacking tumor cells of Ru/Ir–arene complexes based on meclofenamic acid <i>via</i> cyclooxygenase-2 inhibition

Huang, Yuanlei; Lv, Mengdi; Guo, Binglian; Hu, Guojing; Su, Zhi; Xue, Xueling; Liu, Hong‐Ke

doi:10.1039/d3dt00282a

Cited by 2 publications

(1 citation statement)

References 45 publications

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“…Platinum complexes represent one of the great successes in the area of anticancer drugs, although the emerging drug-resistance and systemic toxicity have somewhat hampered their clinical applications and efficacy. Recently, a new direction in the development of metallodrugs to circumvent the drawbacks − associated with the platinum complexes and linked to the rise of transition metal bioorganometallic chemistry has gradually come to the fore. − Among the organometallic complexes that can be used as antitumoral agents, those of iron, an earth-abundant and inexpensive metal, occupy a privileged position, mostly featuring ferrocene, a compact, stable, nontoxic metallocene showing reversible redox properties. − …”

Section: Introductionmentioning

confidence: 99%

Deciphering the Diversified Metabolic Behavior of Hydroxyalkyl Ferrocidiphenols as Anticancer Complexes

Wang,

Fan,

Xie

et al. 2023

J. Med. Chem.

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Ferrocidiphenols possessing appropriate substituents in the aliphatic chain have very promising anticancer properties, but a systematic approach to deciphering their diversified metabolic behavior has so far been lacking. Herein, we show that a series of novel ferrocidiphenols bearing different hydroxyalkyl substituents exhibit strong anticancer activity as revealed in a range of in vitro and in vivo experiments. Moreover, they display diversified oxidative transformation profiles very distinct from those of previous complexes, shown by the use of chemical and enzymatic methods and in cellulo and in vivo metabolism studies. In view of this phenomenon, unprecedented chemo-evolutionary sequences that connect all the ferrocidiphenol-related intermediates and analogues have been established. In addition, a comprehensive density functional theory (DFT) study has been performed to decipher the metabolic diversification profiles of these complexes and demonstrate the delicate modulation of carbenium ions by the ferrocenyl moiety, via either αor β-positional participation.

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Section: Introductionmentioning

confidence: 99%

Deciphering the Diversified Metabolic Behavior of Hydroxyalkyl Ferrocidiphenols as Anticancer Complexes

Wang,

Fan,

Xie

et al. 2023

J. Med. Chem.

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Mitochondria-targeted ruthenium complexes can be generated in vitro and in living cells to target triple-negative breast cancer cells by autophagy inhibition

Zhang,

Wang,

et al. 2024

Journal of Inorganic Biochemistry

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Selectively attacking tumor cells of Ru/Ir–arene complexes based on meclofenamic acid via cyclooxygenase-2 inhibition

Abstract: Breast cancer (BC) is one of the most common malignant tumor and often accompanied by inflammatory processes. Inflammation is an essential component of the tumor microenvironment, which might influence the...

Cited by 2 publications

References 45 publications

Deciphering the Diversified Metabolic Behavior of Hydroxyalkyl Ferrocidiphenols as Anticancer Complexes

Deciphering the Diversified Metabolic Behavior of Hydroxyalkyl Ferrocidiphenols as Anticancer Complexes

Mitochondria-targeted ruthenium complexes can be generated in vitro and in living cells to target triple-negative breast cancer cells by autophagy inhibition

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