2007
DOI: 10.4161/cbt.6.2.3628
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Selectively oncolytic mutant of HSV-1 lyses HeLa cells mediated by Ras/RTN3

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Cited by 6 publications
(3 citation statements)
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“…It has been observed that RTN3 was overexpressed in astrocytoma compared to non-cancerous tissue 34 . It’s reported that RTN3 could interact with the oncogene Ras at endoplasmic reticulum 35 . Further work needs to be done to assess the role of RTN3 in tumorigenesis especially in HCC.…”
Section: Discussionmentioning
confidence: 99%
“…It has been observed that RTN3 was overexpressed in astrocytoma compared to non-cancerous tissue 34 . It’s reported that RTN3 could interact with the oncogene Ras at endoplasmic reticulum 35 . Further work needs to be done to assess the role of RTN3 in tumorigenesis especially in HCC.…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, studies in HeLa cells revealed that RTN3 physically associates with Ras on the endoplasmic reticulum and proposed that RTN3, at least in the model tested, could regulate Ras localization and functionality. Specifically, it is speculated that RTN3 “traps” Ras on the ER, rendering it inactive, by disrupting its redistribution on the plasma membrane (Su et al, 2007 ). Next, RTN3 was recently identified as a novel prognostic marker for HCC together with UPB1 and SOCS2.…”
Section: Selective Autophagy Components In Cancermentioning
confidence: 99%
“…sh-FNTA: 68 The shRNA vector into PGH1/RFP/Neo were constructed by GenePharma. 5'-CACCGATCCGGTGCCGCAGAATGATTCAAGAGATCATTCTGCGGCACCGGATTTTTTTG-3’.…”
Section: Methodsmentioning
confidence: 99%