Selectivity of a thiosemicarbazonatocopper(ii) complex towards duplex RNA. Relevant noncovalent interactions both in solid state and solution

Abstract

Intercalation of [CuL]+ into RNA causes an increase of melting temperature of 28 °C in contrast to the 0.6 °C for DNA.

Revisiting the thiosemicarbazonecopper(II) reaction with glutathione. Activity against colorectal carcinoma cell lines

“…Thiosemicarbazones (TSCs) are sulfur-containing organic substances whose biological properties have been extensively studied [1][2][3][4][5][6][7][8], in particular their activities against microbial diseases as malaria, small-pot, influenza, leishmaniasis or chagas [9][10][11][12][13][14], neurological pathologies [15,16] and cancer [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36]. Different biological targets have been identified, like DNA [37][38][39], RNA [40] and several enzymes as RNA-dependent DNA polymerases [41], xanthine oxidoreductase [42], thioredoxin reductase [43,44], topoisomerase IIa [45][46][47] or s...…”

Perchlorate-induced structural diversity in thiosemicarbazone copper(ii) complexes provides insights to understand the reactivity in acidic and basic media

“…Some of the crystals whose structures are reported here were serendipitously obtained when we were looking into the reaction of the HL-Cu( ii ) system with nucleobases and nucleotides. 97,98 For that reason, we focused on the search for rational methods to attain them (see Experimental section). It is worth noting the nearly ubiquitous presence of compound 1 , even as an impurity, in many of the assays carried out in spite of its high solubility in water.…”

“…7 Concerning the nitrate ligands, there is a marked parallelism with the composition and structures reported here and those of previously published nitrate compounds, as discussed in the crystallographic section and the chapter entitled Summary about the parallel Cu 2+ /HL/ NO Some of the crystals whose structures are reported here were serendipitously obtained when we were looking into the reaction of the HL-Cu(II) system with nucleobases and nucleotides. 97,98 For that reason, we focused on the search for rational methods to attain them (see Experimental section). It is worth noting the nearly ubiquitous presence of compound 1, even as an impurity, in many of the assays carried out in spite of its high solubility in water.…”

Ternary copper(ii) complexes of 1,10-phenanthroline and coumarin-based oxylacetates as pro-apoptotic UPR CHOP inducers

“…8 Moreover, these complexes may interact with DNA differently than Pt( ii )-based drugs, or trigger cell death by targeting different molecular pathways and/or biomolecules. 9 Copper( ii ) is a typical example of an endogenous ion that shares with cisplatin the same transporter protein (hCtr1). 10 Many nitrogen-containing ligands, such as 1,10-phenanthroline, have been tested for their antitumor activity on different human cancer cell lines, both alone and as part of metal complexes.…”