Selectivity of Human T Lymphotropic Virus Type-1 (HTLV-1) and HTLV-2 Infection Among Different Populations in Brazil

Gabbai, Alberto A.; Bordin, José Orlando; Vieira-Filho, João Paulo Botelho; Kuroda, Akio; Oliveira, A. S.B.; Cruz, Maria Veneranda M.; Ribeiro, Anderson Alves; Delaney, Stephen; Henrard, Denis; Rosario, Fernando del; Román, Gustavo C.

doi:10.4269/ajtmh.1993.49.664

Cited by 49 publications

(29 citation statements)

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“…Nonetheless, previous Brazilian studies presented conflicting data with regard to the association between intravenous drug use and HTLV-2 infection. Although some investigators have indicated an epidemiologic association 14 , studies conducted more recently have highlighted the leading role of HTLV-1 among HTLV-infected drug addicts in Bahia 11 . Our results reinforce the idea that HTLV-2 infection is possibly spread by means of injectable drug use, and thus suggest that the way in which this retrovirus circulates may vary between different Brazilian geographic regions.…”

Section: Discussionmentioning

confidence: 99%

Hepatitis C virus and human T-lymphotropic virus coinfection: epidemiological, clinical, laboratory and histopathological features

Milagres

Duarte

Viso

et al. 2009

Rev. Soc. Bras. Med. Trop.

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Twenty-four hepatitis C virus patients coinfected with human T-lymphotropic virus type 1 were compared with six coinfected with HTLV-2 and 55 with HCV alone, regarding clinical, epidemiological, laboratory and histopathological data. Fischer's discriminant analysis was applied to define functions capable of differentiating between the study groups (HCV, HCV/HTLV-1 and HCV/HTLV-2). The discriminant accuracy was evaluated by cross-validation. Alcohol consumption, use of intravenous drugs or inhaled cocaine and sexual partnership with intravenous drug users were more frequent in the HCV/HTLV-2 group, whereas patients in the HCV group more often reported abdominal pain or a sexual partner with hepatitis. Coinfected patients presented higher platelet counts, but aminotransferase and gamma-glutamyl transpeptidase levels were higher among HCV-infected subjects. No significant difference between the groups was seen regarding liver histopathological findings. Through discriminant analysis, classification functions were defined, including sex, age group, intravenous drug use and sexual partner with hepatitis. Cross-validation revealed high discriminant accuracy for the HCV group. Key-words:Hepatitis C virus. Human T-lymphotropic virus type 1. Human T-lymphotropic virus type 2. Epidemiological studies. Discriminant analysis. RESUMOCompararam-se 24 pacientes coinfectados pelos vírus da hepatite C/vírus linfotrópico de células T humanas do tipo 1 com 6 coinfectados por VHC/ HTLV-2 e 55 infectados pelo VHC, no tocante a dados clínico-epidemiológicos, laboratoriais e histopatológicos. A análise discriminante de Fischer foi utilizada para definir funções capazes de diferenciar os grupos de estudo (VHC, VHC/HTLV-1 e VHC/HTLV-2). A acurácia discriminatória foi avaliada pelo por validação cruzada. O uso de álcool, drogas endovenosas, cocaína inalatória e a parceria sexual com UDEV foram mais freqüentes no grupo VHC/HTLV-2, enquanto queixa de dor abdominal e parceiro sexual com hepatite predominaram no grupo VHC. Os coinfectados apresentaram número maior de plaquetas, enquanto as aminotransferases e a gamaglutamiltranspeptidase foram mais altas no grupo VHC. Não houve diferença entre os grupos à análise histopatológica do fígado. Por análise discriminante definiram-se funções classificatórias, incluindo as variáveis sexo, faixa etária, uso de drogas endovenosas e parceiro sexual com hepatite, com acurácia discriminante alta para o grupo VHC. Palavras-chaves:Vírus da hepatite C. Vírus linfotrópico de células T humanas do tipo 1. Vírus linfotrópico de células T humanas do tipo 2. Estudos epidemiológicos. Análise discriminante.

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Section: Discussionmentioning

confidence: 99%

Hepatitis C virus and human T-lymphotropic virus coinfection: epidemiological, clinical, laboratory and histopathological features

Milagres

Duarte

Viso

et al. 2009

Rev. Soc. Bras. Med. Trop.

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“…In Brazil, the rate of HTLV-1 infection among blood donors ranges from 0.3% to 0.4% (Gabbai et al 1993, Segurado et al 1997. In female commercial sex workers examined in Fortaleza, State of Ceará, it was found a rate of infection by HTLV-1 of 1.21% (Broutet et al 1996).…”

Section: Coinfection By Strongyloides Stercoralis In Blood Donorsmentioning

confidence: 99%

Coinfection by Strongyloides stercoralis in blood donors infected with human T-cell leukemia/lymphoma virus type 1 in São Paulo city, Brazil

Chieffi

Chiattone²,

Feltrim³

et al. 2000

Mem. Inst. Oswaldo Cruz

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“…[1][2][3] In Brazil, considered the country with the largest number of people infected by HTLVs, 4 HTLV-2 is considered endemic among indigenous populations of the Amazon region and among Indians of the south region, and is present in IDUs of urban areas and in patients with HIV/AIDS. [5][6][7][8][9][10] The HTLV-1/2 are low replicating viruses, thus have little genetic sequence variation. 11,12 However, the env structural gene and the long terminal repeat (LTR) region containing the viral promoter are the most variable regions, thus are useful for virus subtyping.…”

Section: Introductionmentioning

confidence: 99%

Human T Cell Lymphotropic Virus Type 2a Strains Among HIV Type 1-Coinfected Patients from Brazil Have Originated Mostly from Brazilian Amerindians

Magri

Brígido²,

Morimoto³

et al. 2013

AIDS Research and Human Retroviruses

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The human T cell lymphotropic virus type 2 (HTLV-2) is found mainly in Amerindians and in intravenous drug users (IDUs) from urban areas of the United States, Europe, and Latin America. Worldwide, HTLV-2a and HTLV-2b subtypes are the most prevalent. Phylogenetic analysis of HTLV-2 isolates from Brazil showed the HTLV-2a subtype, variant -2c, which spread from Indians to the general population and IDUs. The present study searched for the types of HTLV-2 that predominate among HIV-1-coinfected patients from southern and southeastern Brazil. Molecular characterization of the LTR, env, and tax regions of 38 isolates confirmed the HTLV-2c variant in 37 patients, and one HTLV-2b in a patient from Paraguay. Phylogenetic analysis of sequences showed different clades of HTLV-2 associated with risk factors and geographic region. These clades could represent different routes of virus transmission and/or little diverse evolutionary rates of virus. Taking into account the results obtained in the present study and the lack of the prototypic North American HTLV-2a strain and HTLV

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Selectivity of Human T Lymphotropic Virus Type-1 (HTLV-1) and HTLV-2 Infection Among Different Populations in Brazil

Cited by 49 publications

References 0 publications

Hepatitis C virus and human T-lymphotropic virus coinfection: epidemiological, clinical, laboratory and histopathological features

Hepatitis C virus and human T-lymphotropic virus coinfection: epidemiological, clinical, laboratory and histopathological features

Coinfection by Strongyloides stercoralis in blood donors infected with human T-cell leukemia/lymphoma virus type 1 in São Paulo city, Brazil

Human T Cell Lymphotropic Virus Type 2a Strains Among HIV Type 1-Coinfected Patients from Brazil Have Originated Mostly from Brazilian Amerindians

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