Selectivity of Tryptophan and Phenylalanine Adsorption by Activated Coconut Carbon of Medical Assignment

Farbun, I. A.; Trykhlib, V.A.

doi:10.1007/s11237-023-09766-5

Cited by 1 publication

(2 citation statements)

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“…Further, this work indicated how important each of the dimensions of porosity and nanoporosity is in cell culture. Concerning the work [60], our research, taking into account the proposed materials, convinces the development of SACs in new promising medical applications.…”

Section: Discussionmentioning

confidence: 55%

“…Spherical carbon aerogels (SCAs) obtained by Long et al [59] were used in the adsorption of the following biomolecules: l-phenylalanine, vitamin B12, α-chymotrypsin, and bovine serum albumin (BSA). However, the latest paper in which phenylalanine adsorption by porous carbon material is described in [60] used activated coconut carbon to confirm the legitimacy of using this material as an alternative in amino acid therapy. This material can help to remove excess aromatic and heterocyclic amino acids in the treatment of i.e.…”

Section: Discussionmentioning

confidence: 99%

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Adhesion and morphology of mammalian cells on nanoporous and nonporous spherical carbon substrates

Osuchowski,

Dobrzyńska,

Kasprzycka

et al. 2023

Nanotechnology

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Three spherical activated carbons (SACs) were used as substrates for mammalian cell proliferation. SACs were obtained by carbonizing styrene-co-divinylbenzene ion exchangers 35WET, XAD-4, or 1200H. The new materials (XAD_C, WET_C, and H_C) were characterized by adsorption-desorption nitrogen isotherms and mercury intrusion porosimetry. XAD_C and WET_C exhibited well-developed BET surface areas, similar total pore volumes, and highly different pore size distributions. H_C was nonporous spherical material – reference material. The XAD_C was meso-macroporous, but the WET_C was micro-mesoporous. All SACs were not cytotoxic toward Leydig TM3 cells. The differences in porous structure and morphology of the carbon scaffolds led to morphological differences in adhered cells. The monolayer of cells was distributed flat over the entire WET_C and H_C surfaces. Leydig TM3 cells adhered to nonporous SAC but were easily washed out due to weak adhesion. The cells adhered in clusters to XAD_C and proliferated in clusters. As microscopic techniques and viability tests demonstrated, only nanoporous carbons provided a good surface for the attachment and proliferation of eukaryotic cells.

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Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 99%