Selektive chemische Ausschaltung der Harnkan�lchen I. Ordnung bei Kaninchen

Renal toxicity of aristolochic acid in rats as an example of nephrotoxicity testing in routine toxicology

“…The present results are in good agreement with the findings reported in previous publications on the nephrotoxic properties of AA in experimental animals (Martincic 1956;MEhes et al 1958;Hedwall 1961;Peters and Hedwall 1963;Mengs 1987;Mengs and Stotzem 1992) and from the use of AA in human beings (Jackson et al 1964;Thiele et al 1967).…”

Chronic aristolochic acid toxicity in rabbits: A model of Chinese herbs nephropathy?

“…tion of interstitial edema with proximal tubule cell dam-In two of the latter animals, a discrete band at molecular age is reminiscent of the acute tubular necrosis observed weight of 67 kD was observed together, in one of them, after massive AA dosage [7][8][9][10]. A daily, mild, cellular with another band at 20 kD (data not shown).…”

“…ences in the susceptibility of the kidney to the toxicity of AA. Acute nephrotoxicity appears similar in humans Several differences have to be taken into account when comparing CHN patients with the experimental AA-and rabbits [7,8], but is markedly lower in rats and mice [9,10], whereas it is virtually absent in dogs, cats, frogs, treated rabbit model. Although rabbits and humans have a similar sensitivity to the acute toxic effect of AA [7,8], and porpoises [7].…”

“…Acute nephrotoxicity appears similar in humans Several differences have to be taken into account when comparing CHN patients with the experimental AA-and rabbits [7,8], but is markedly lower in rats and mice [9,10], whereas it is virtually absent in dogs, cats, frogs, treated rabbit model. Although rabbits and humans have a similar sensitivity to the acute toxic effect of AA [7,8], and porpoises [7]. A similar interspecies difference emerges for chronic AA nephrotoxicity; in contrast with it is noteworthy that the AA dosage used in this study to obtain renal lesions is six times higher (on a per weight the rat, which appears immune to chronic AA exposure [11], rabbits and apparently humans develop severe renal basis) in the rabbit than that reported in CHN patients [11].…”

Über die Aristolochia-Nephropathie - Phytotherapie -

“…Die Nephrotoxizität von Aristolochiasäure war allerdings schon seit den 50er Jahren bekannt [22,24,38,42,51]. Sie ist bei verschiedenen Tierarten offenbar unterschiedlich ausgeprägt.…”