Selenium alleviates heart remodeling through Sirt1/AKT/GSK-3β pathway

Cui, Shengyu; Luo, Yinhua; Li, Yuanhong; Zhao, Jinbo; Fang, Can; Xia, Hao; Zhang, Changjiang

doi:10.1016/j.intimp.2022.109158

Cited by 14 publications

(4 citation statements)

References 49 publications

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“…Selenium acts as a critical antioxidant in affecting various tissues and cells and contributes to the removal of ROS, especially the removal of hydroperoxides. This effect has been reported in the heart [110], liver [111], kidneys [112], thyroid [113], and brain [114] (the mechanism is described later). In addition, the antioxidant effect of selenium may be responsible for its resistance to inflammation, apoptosis, and autophagy.…”

Section: Oxidative Stresssupporting

confidence: 56%

Selenium and Selenoproteins in Health

Zhang

Wei

2023

Biomolecules

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Selenium is a trace mineral that is essential for health. After being obtained from food and taken up by the liver, selenium performs various physiological functions in the body in the form of selenoproteins, which are best known for their redox activity and anti-inflammatory properties. Selenium stimulates the activation of immune cells and is important for the activation of the immune system. Selenium is also essential for the maintenance of brain function. Selenium supplements can regulate lipid metabolism, cell apoptosis, and autophagy, and have displayed significant alleviating effects in most cardiovascular diseases. However, the effect of increased selenium intake on the risk of cancer remains unclear. Elevated serum selenium levels are associated with an increased risk of type 2 diabetes, and this relationship is complex and nonlinear. Selenium supplementation seems beneficial to some extent; however, existing studies have not fully explained the influence of selenium on various diseases. Further, more intervention trials are needed to verify the beneficial or harmful effects of selenium supplementation in various diseases.

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Section: Oxidative Stresssupporting

confidence: 56%

Selenium and Selenoproteins in Health

Zhang

Wei

2023

Biomolecules

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“…In particular, Se application improved heart antioxidant levels (SOD, SOD2, GPX and GSH), reduced expression of collagen I and III, GSK-3β, AKT and α-SMA, and reduced the apoptosis rate and ROS levels in TGF-β1-treated rat myoblasts. Additionally, Se treatment up-regulated the level of Sirtuin 1 [74], which promotes autophagy and inhibits apoptosis, thus providing cardioprotective effects in different cardiovascular diseases [75]. In total, these results demonstrate that Se's cardioprotective effects on heart fibrosis, hypertrophy and failure are mediated through regulating ROS status, apoptosis/autophagy rate, AKT/GSK-3β and Sirt1 pathways.…”

Section: Se In Regulation Of Apoptosis/autophagy Balancementioning

confidence: 73%

The Role of Selenium in Atherosclerosis Development, Progression, Prevention and Treatment

et al. 2023

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Selenium is an essential trace element that is essential for various metabolic processes, protection from oxidative stress and proper functioning of the cardiovascular system. Se deficiency has long been associated with multiple cardiovascular diseases, including endemic Keshan’s disease, common heart failure, coronary heart disease, myocardial infarction and atherosclerosis. Through selenoenzymes and selenoproteins, Se is involved in numerous crucial processes, such as redox homeostasis regulation, oxidative stress, calcium flux and thyroid hormone metabolism; an unbalanced Se supply may disrupt these processes. In this review, we focus on the importance of Se in cardiovascular health and provide updated information on the role of Se in specific processes involved in the development and pathogenesis of atherosclerosis (oxidative stress, inflammation, endothelial dysfunction, vascular calcification and vascular cell apoptosis). We also discuss recent randomised trials investigating Se supplementation as a potential therapeutic and preventive agent for atherosclerosis treatment.

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“…Circulating SIRT1 was also previously shown to be reduced in elderly Italians with CVD in the presence of Se deficiency [ 19 ]. In addition, in a review, Packer et al reported the cardioprotective effects of SIRT1, which would especially benefit heart failure patients [ 39 ], and Shengyu et al reported a positive relationship between Se and the expression of SIRT1, evidencing a protective effect in cardiac hypertrophy [ 40 ]. Circulating SIRT1 was further reported to be inversely associated with epicardial fat thickness in obese subjects [ 41 ], and the plasma levels of SIRT1 were lower in patients with acute cerebrovascular stroke compared to controls, with no significant difference between ischemic and hemorrhagic groups [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Increased SIRT1 Concentration Following Four Years of Selenium and Q10 Intervention Associated with Reduced Cardiovascular Mortality at 10-Year Follow-Up—Sub-Study of a Previous Prospective Double-Blind Placebo-Controlled Randomized Clinical Trial

et al. 2023

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Background: Selenium and coenzyme Q10 (SeQ10) possess antioxidant and anti-inflammatory properties, potentially mediated via Sirtuin1 (SIRT1). We aimed to investigate the influence of a SeQ10 intervention on SIRT1 concentration, with potential interactions with microRNAs. Methods: In this sub-study of a prospective double-blind placebo-controlled clinical trial, healthy subjects (mean age 76 years) were randomized to receive an active treatment (n = 165, combined 200 µg/day of Se and 200 mg/day of Q10) or a placebo (n = 161). SIRT1 concentration and microRNAs were measured with ELISA and PCR, respectively. Results: After four years, SIRT1 concentration was increased in the active treatment group, with mean (SD) ng/mL of 469 (436) vs. 252 (152), p < 0.001, and decreased in the placebo group, 190 (186) vs. 252 (162), p = 0.002, and the differences between the groups were significant (p = 0.006, adjusted). Those who suffered CV death during a 10-year follow-up (n = 25 and n = 52 in the active treatment and placebo groups, respectively) had significantly lower baseline SIRT1 concentrations compared to the survivors (p < 0.001). MiR-130a-3p was significantly downregulated during the intervention and correlated inversely with SIRT1 at baseline (r = −0.466, p = 0.007). Conclusion: The increased SIRT1 concentration after the SeQ10 intervention associated with reduced CV mortality, partly mediated via miR-1303a-3p, suggests that SIRT1 is an additional mediator of the intervention, preventing vascular ageing.

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Selenium alleviates heart remodeling through Sirt1/AKT/GSK-3β pathway

Cited by 14 publications

References 49 publications

Selenium and Selenoproteins in Health

Selenium and Selenoproteins in Health

The Role of Selenium in Atherosclerosis Development, Progression, Prevention and Treatment

Increased SIRT1 Concentration Following Four Years of Selenium and Q10 Intervention Associated with Reduced Cardiovascular Mortality at 10-Year Follow-Up—Sub-Study of a Previous Prospective Double-Blind Placebo-Controlled Randomized Clinical Trial

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