Selenium alleviates modafinil-induced neurobehavioral toxicity in rat via PI3K/Akt/mTOR/GSK3B signaling pathway and suppression of oxidative stress and apoptosis: in vivo and in silico study

Curcumin-loaded scaffolds in bone regeneration

“…Among the key regulatory elements implicated in apoptosis, inflammation, and oxidative stress-related disorders is glycogen synthase kinase-3 beta (GSK3β). Notably, GSK3β diminishes the expression of Erythroid-derived 2-like 2 (Nrf2), a transcription factor crucial for orchestrating the expression of antioxidant-related genes [ 65 ]. Li et al demonstrated that curcumin possesses the capacity to promote the differentiation of MC3T3-E1 cells into osteoblasts by activating the GSK3β/Nrf2 pathway under conditions of oxidative stress [ 8 ].…”