Selenium and anticarcinogenesis: underlying mechanisms

Jackson, Matthew I.; Combs, Gerald F.

doi:10.1097/mco.0b013e3283139674

Cited by 192 publications

(136 citation statements)

References 61 publications

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“…Se-methylselenocysteine (MeSeCys) is used in the dietary chemoprevention of tumors (1). It is metabolized by selenocysteine lyase (␤-lyase) producing methylselenol, which causes apoptosis in cancer cells by redox cycling and protein thiol modification (1,15,23). Selenocysteine lyases are widely distributed among bacteria (8).…”

mentioning

confidence: 99%

Modifying Culture Conditions in Chemical Library Screening Identifies Alternative Inhibitors of Mycobacteria

Miller

Nisa

Dempsey

et al. 2009

Antimicrob Agents Chemother

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In this study, application of a dual absorbance/fluorescence assay to a chemical library screen identified several previously unknown inhibitors of mycobacteria. In addition, growth conditions had a significant effect on the activity profile of the library. Some inhibitors such as Se-methylselenocysteine were detected only when screening was performed under nutrient-limited culture conditions as opposed to nutrient-rich culture conditions. We propose that multiple culture condition library screening is required for complete inhibitory profiling and for maximal antimycobacterial compound detection.

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mentioning

confidence: 99%

Modifying Culture Conditions in Chemical Library Screening Identifies Alternative Inhibitors of Mycobacteria

Miller

Nisa

Dempsey

et al. 2009

Antimicrob Agents Chemother

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“…The protection of selenium against cancer is also linked to the activities of hydrogen selenide and selenomethionine present in cells, which may be responsible for modifying protein thiols and mimicking methionine, leading to higher methylating efficiency of RNA and thiols (28). Some studies suggest that this essential dietary trace element has antioxidant properties and that it produces effects on apoptosis, DNA repair, and carcinogen metabolism.…”

Section: Discussionmentioning

confidence: 99%

Selenium and Bladder Cancer Risk: a Meta-analysis

Amaral

Cantor

Silverman

et al. 2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

104

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Background: Selenium is considered to be an antioxidant, and its high levels have been inversely associated with cancer risk of several sites. This meta-analysis examined the relationship between levels of selenium measured in serum and toenails, and the risk of bladder cancer.Methods: A meta-analysis using data from seven published epidemiologic studies (three case-control, three nested case-control, one case-cohort) published before March 2010 was done to examine the association between levels of selenium and bladder cancer. Fixed and random effects analyses were done to calculate meta-odds ratio (mOR) and 95% confidence intervals (CI). Heterogeneity among studies was measured by the I 2 statistic.

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“…A variety of mechanisms have been proposed for selenium's anti-tumor activity: free radical scavenging (Murawaki et al, 2008), modifying thiols, mimiching mimicking methionine methionine which leads to to higher methylating efficiency of RNA and thiols (Jackson & Combs, 2008), enhancement of p53 activity towards DNA repair or apoptosis (Smith et al, 2004) and anti-androgenic activity, which is especially relevant in prostate cancer (Husbeck et al, 2006;Gazi et al, 2007). The clinical evidence for selenium's anti bladder cancer activity is somewhat controversial.…”

Section: Seleniummentioning

confidence: 99%