Selenium and breast cancer – An update of clinical and epidemiological data

Flowers, Brenna; Poles, Allison; Kastrati, Irida

doi:10.1016/j.abb.2022.109465

Cited by 12 publications

(10 citation statements)

References 56 publications

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“…The majority of early animal data on chemoprevention with selenium was focused on mammary carcinogenesis [ 3 , 4 , 5 ]. In the case of breast cancer, a review summarizing the most recent evidence did not support a preventive role of selenium on cancer incidence [ 14 ]. However, breast cancer patients in the lowest quartile of selenium status had a reduced cancer-specific survival compared to those in the highest quartile [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…In the case of breast cancer, a review summarizing the most recent evidence did not support a preventive role of selenium on cancer incidence [ 14 ]. However, breast cancer patients in the lowest quartile of selenium status had a reduced cancer-specific survival compared to those in the highest quartile [ 14 ]. This indicates that selenium supplementation may be of therapeutic benefit in a subset of breast cancer patients with low selenium status.…”

Section: Introductionmentioning

confidence: 99%

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Distinct Roles of SELENOF in Different Human Cancers

et al. 2023

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SELENOF, previously known as SEP15, is a selenoprotein that contains selenium in the form of the amino acid selenocysteine. Like other selenoproteins, the role for SELENOF in carcinogenesis has been investigated due to its altered expression compared to the corresponding normal tissue, its molecular function, and the association of genetic variations in the SELENOF gene to cancer risk or outcome. This review summarizes SELENOF’s discovery, structure, cellular localization, and expression. SELENOF belongs to a new family of thioredoxin-like proteins. Published data summarized here indicate a likely role for SELENOF in redox protein quality control, and in the regulation of lipids, glucose, and energy metabolism. Current evidence indicates that loss of SELENOF contributes to the development of prostate and breast cancer, while its loss may be protective against colon cancer. Additional investigation into SELENOF’s molecular mechanisms and its impact on cancer is warranted.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Distinct Roles of SELENOF in Different Human Cancers

et al. 2023

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“…SELENOF, previously known as SEP15, is a selenoprotein that contains selenium in the form of the amino acid selenocysteine [1]. Its role in carcinogenesis has been investigated due to its altered expression in tumors compared to corresponding normal tissue and the association of genetic variations in the SELENOF gene with cancer risk or outcome (reviewed in [2,3]). SELENOF has been implicated in breast cancer based on the observation that loss of heterozygosity at the SELENOF locus occurs in breast tumors [4].…”

Section: Introductionmentioning

confidence: 99%

“…This region is commonly deleted in breast tumors, indicating that it may harbor putative tumor suppressors [5]. SELENOF is also highly responsive to selenium bioavailability, and a summary of the recent largestto-date clinical and epidemiological studies indicates that selenium status correlates with 2 of 13 breast cancer survival [2]. Based on these findings, the role of SELENOF in breast cancer was investigated [6].…”

Section: Introductionmentioning

confidence: 99%

SELENOF Controls Proliferation and Cell Death in Breast-Derived Immortalized and Cancer Cells

Ekyalongo

Flowers

Sharma

et al. 2023

Cancers

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SELENOF expression is significantly lower in aggressive breast tumors compared to normal tissue, indicating that its reduction or loss may drive breast tumorigenesis. Deletion of SELENOF in non-tumorigenic immortalized breast epithelial MCF-10A cells resulted in enhanced proliferation, both in adherent culture and matrix-assisted three-dimmensional (3D) growth. Modulation of SELENOF in vitro through deletion or overexpression corresponded to changes in the cell-cycle regulators p21 and p27, which is consistent with breast tumor expression data from the METABRIC patient database. Together, these findings indicate that SELENOF affects both proliferation and cell death in normal epithelial and breast cancer cells, largely through the regulation of p21 and p27. In glandular cancers like breast cancer, the filling of luminal space is one of the hallmarks of early tumorigenesis. Loss of SELENOF abrogated apoptosis and autophagy, which are required for the formation of hollow acini in MCF-10A cells in matrix-assisted 3D growth, resulting in luminal filling. Conversely, overexpression of SELENOF induced cell death via apoptosis and autophagy. In conclusion, these findings are consistent with the notion that SELENOF is a breast tumor suppressor, and its loss contributes to breast cancer etiology.

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“…The positive and negative effects of Se are determined by its dose and form [ 24 ]. It is still unknown how Se affects the occurrence of breast cancer [ 25 ]. Most epidemiological studies reported no significant relationship between dietary Se intake and breast cancer risk [ 11 , 13 , 16 , 26 , 27 , 28 , 29 ]; however, a few studies found a negative association [ 30 , 31 , 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

Association of Dietary Intake of Zinc and Selenium with Breast Cancer Risk: A Case-Control Study in Chinese Women

Liu

Wang

et al. 2023

Nutrients

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As major nonenzymatic antioxidant components in the body, dietary Zinc (Zn) and Selenium (Se) may have an impact on breast cancer development. This study aimed to investigate the relationship between dietary Zn, Se intake and breast cancer risk in Chinese women. The case-control study included 1591 cases and 1622 age-frequency matched controls. Dietary intake was collected using a validated food frequency questionnaire. Dietary Zn and Se were divided into four categories: Zn/Se from plants, Zn/Se from meat, Zn/Se from red meat, and Zn/Se from white meat. Unconditional logistic regression models and restricted cubic spline analyses were performed to identify potential associations. Zn from white meat intake was linearly and inversely associated with breast cancer risk, and Se from red meat intake was linearly and positively associated with breast cancer risk, with adjusted odds ratio and 95% confidence interval of 0.76 (0.61–0.95) and 1.36 (1.04–1.77), respectively. Non-linear relationships were found between total dietary Zn, Zn from meat, Zn from red meat intake and breast cancer risk (pnon-linearity < 0.05). In conclusion, dietary Zn and Se intake were associated with breast cancer risk in Chinese women, and the optimal intake of Zn may be beneficial for breast cancer prevention.

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Selenium and breast cancer – An update of clinical and epidemiological data

Cited by 12 publications

References 56 publications

Distinct Roles of SELENOF in Different Human Cancers

Distinct Roles of SELENOF in Different Human Cancers

SELENOF Controls Proliferation and Cell Death in Breast-Derived Immortalized and Cancer Cells

Association of Dietary Intake of Zinc and Selenium with Breast Cancer Risk: A Case-Control Study in Chinese Women

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