Selenium and mercury concentrations in biological samples from patients with COVID-19

Chanihoon, Ghulam Qadir; Afridi, Hassan Imran; Unar, Ahsanullah; Talpur, Farah Naz; Kalochi, Hadi Bakhsh; Nassani, Rayan; Laghari, Nazia; Uddin, Najam; Ali, Ghulam; Chandio, Anees Ur Rahman

doi:10.1016/j.jtemb.2022.127038

Cited by 14 publications

(11 citation statements)

References 74 publications

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“…To summarize, these articles confirm that most of patients with COVID-19 exhibit selenium, zinc, iron, calcium and sodium deficiencies and high copper, lead, arsenic and mercury concentrations [3] , [4] , [5] , [6] , [7] . Some of these modifications were associated with inflammatory biological index [7] .…”

mentioning

confidence: 62%

The different faces of inorganic elements in SARS-CoV-2 infection

Arnaud

González-Estecha

Skalny

2022

Journal of Trace Elements in Medicine and Biology

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confidence: 62%

The different faces of inorganic elements in SARS-CoV-2 infection

Arnaud

González-Estecha

Skalny

2022

Journal of Trace Elements in Medicine and Biology

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“…The selenium levels of thirty-two healthy subjects were the reference range Selenium level was lower than the comparison group, 215⋅34 ± 49⋅83 ng/ml v. 255⋅23 ± 42⋅67 ng/ml, P < 0⋅001, COVID-19 positive patients and healthy subjects, respectively Chanihoon, 2022 (16) Comparative Alkattan, 2021 (17) Cross-sectional study 80 COVID-19 patients in a Saudi Arabian hospital Normal range of selenium in blood serum 70-150 μg/l were considering Studies groups were divided into non-severe cases and severe cases. the mean selenium in both study groups was within the normal range (138 μg/l).…”

Section: Resultsmentioning

confidence: 92%

Selenium serum levels in patients with SARS-CoV-2 infection: a systematic review and meta-analysis

Roldán-Bretón,

Capuchino-Suárez,

Mejía-León

et al. 2023

J Nutr Sci

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The nutritional status is a determinant of the immune response that promotes a cellular homeostasis. In particular, adequate selenium levels lead to a better antioxidant and immune response. The aim of this work is to assess whether blood selenium levels, at time of SARS-CoV-2 infection, have an impact on the development and severity of COVID-19. A systematic review and meta-analysis of comparative and descriptive studies using MeSH terms, selenium and COVID-19 was performed. We searched bibliographic databases up to 17 July 2022 in PubMed and ScienceDirect. Studies that reported data on blood selenium levels were considered. A total of 629 articles were examined by abstract and title, of which 595 abstracts were read, of which 38 were included in the systematic review and 11 in the meta-analysis. Meta-analysis was conducted to mean difference (MD) with a 95 % confidence interval (CI), and heterogeneity was tested by I2 with random factors with a MD between selenium levels, mortality, morbidity and healthy subjects with a P-value of 0⋅05. Selenium levels were higher in healthy people compared to those in patients with COVID-19 disease (six studies, random effects MD: test for overall effect Z = 3⋅28 (P = 0⋅001), 97 % CI 28⋅36 (11⋅41–45⋅31), P < 0⋅00001), but without difference when compared with the degree of severity in mild, moderate or severe cases. In conclusion, the patients with active SARS-CoV-2 infection had lower selenium levels than the healthy population. More studies are needed to evaluate its impact on clinical severity through randomised clinical trials.

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“…Chanihoon et al compared the selenium levels in different biological samples (scalp hair, blood, serum, nasal fluid, sputum and saliva), obtained between October 2021 and January 2022 from multiple hospitals in Sindh (Pakistan), of smoking and non-smoking COVID-19 patients ( n = 52 + 63) and healthy referents ( n = 71 + 87) [ 71 ]. Based on their data, the selenium levels of COVID-19 patients (categorized into mild/severe/critical) were about halved in all biological samples, compared to respective smokers and non-smokers.…”

Section: Resultsmentioning

confidence: 99%

Could Selenium Supplementation Prevent COVID-19? A Comprehensive Review of Available Studies

2023

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The purpose of this review is to systematically examine the scientific evidence investigating selenium’s relationship with COVID-19, aiming to support, or refute, the growing hypothesis that supplementation could prevent COVID-19 etiopathogenesis. In fact, immediately after the beginning of the COVID-19 pandemic, several speculative reviews suggested that selenium supplementation in the general population could act as a silver bullet to limit or even prevent the disease. Instead, a deep reading of the scientific reports on selenium and COVID-19 that are available to date supports neither the specific role of selenium in COVID-19 severity, nor the role of its supplementation in the prevention disease onset, nor its etiology.

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Selenium and mercury concentrations in biological samples from patients with COVID-19

Cited by 14 publications

References 74 publications

The different faces of inorganic elements in SARS-CoV-2 infection

The different faces of inorganic elements in SARS-CoV-2 infection

Selenium serum levels in patients with SARS-CoV-2 infection: a systematic review and meta-analysis

Could Selenium Supplementation Prevent COVID-19? A Comprehensive Review of Available Studies

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