Selenium and rubidium changes in subjects with pathologically altered thyroid

Kvícala, J; Havelka, J; Nĕmec, J; Zeman,

doi:10.1007/bf02784608

Cited by 20 publications

(16 citation statements)

References 18 publications

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“…In a general sense values obtained for Br, Cu, Fe, Rb, Sr, and Zn contents in the NT samples (Table 2) agree well with median of mean values reported by other researches [54][55][56][57][58][59][60][61][62][63][64][65][66]. A number of values for TE mass fractions in literature were not expressed on a dry mass basis.…”

Section: Discussionsupporting

confidence: 87%

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Comparison of trace element contents in normal thyroid and thyroid with Hashimoto's thyroiditis using neutron activation analysis

Zaichick¹

2021

World J. Adv. Res. Rev.

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Role of trace elements (TE) in etiology and pathogenesis of Hashimoto's thyroiditis (HT) is unclear. The aim of this exploratory study was to assess whether there were significant changes in thyroid tissue levels of ten TE (Ag, Co, Cr, Fe, Hg, Rb, Sb, Sc, Se, and Zn) are present in the autoimmune transformed thyroid. Ten TE of thyroid tissue were determined in 8 patients with HT and 105 healthy populations. The measurements were performed using non-destructive instrumental neutron activation analysis with high resolution spectrometry of long-lived radionuclides. Elevated mean values of Ag, Hg, and Rb content were found in thyroid with HT in comparison with normal level (in approximately 21, 30, and 1.6 times, respectively). Because the considerable changes in some TE contents in tissue of thyroid with HT were found, it is reasonable to assume that the levels of these TE in thyroid tissue can be used as HT markers. However, this topic needs additional studies.

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Section: Discussionsupporting

confidence: 87%

“…Comparison of values obtained for Ag, Co, Cr, Fe, Hg, Rb, Sb, Sc, Se, and Zn contents in the NT and HT samples with median of means reported by other researches [9,[54][55][56][57][58][59][60][61][62][63][64][65][66][67][68] depicts in Table 2.…”

Section: Resultsmentioning

confidence: 99%

Comparison of trace element contents in normal thyroid and thyroid with Hashimoto's thyroiditis using neutron activation analysis

Zaichick¹

2021

World J. Adv. Res. Rev.

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“…In particular, the highest concentrations were found in retired mercury mineworkers in Slovenia and in deceased subjects for various "accidental" reasons in Japan. Despite this fact, some studies [35][36][37] report a small decrease in selenium concentration in thyroid tumor. However, such changes were not always connected with the progress of malignancy of disease.…”

Section: D1 (Pmol I/h/mg Protein)mentioning

confidence: 88%

Selenoenzymes, Laboratory Parameters, and Trace Elements in Different Types of Thyroid Tumor

Zagrodzki

Nicol

Arthur

et al. 2009

Biol Trace Elem Res

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This study was performed to investigate selenoenzyme activities and trace element concentrations in thyroid tissues, with reference to other parameters routinely used to characterize thyroid function. This was to reveal relevant parameters as possible additional markers of tumor grade, clinical course, and prognosis of thyroid disorders. The tissue samples were obtained during surgical treatment (total or near total thyroidectomy) of 122 patients with different types of thyroid tumor. For most of the investigated parameters in different groups of patients, we did not find statistically significant differences. In the majority of cases, thyroid benign or malignant tumors were not accompanied by significant derangement of the gland selenoenzymes and of either intrathyroidal or plasma concentration of selenium. Nevertheless, types I and II iodothyronine deiodinases were the most promising (among selenoenzymes) targets for diagnoses and possibly therapy of thyroid tumors. Higher activities of both enzymes in cases with Graves' disease, as compared with other thyroid lesions, suggest their involvement in the pathogenesis of this condition. Patients with struna nodosa had higher levels of thyroid Zn, Cu, and Pb as compared with papillary carcinoma subjects and also a higher level of Cu than follicular carcinoma cases. The above diagnostics may play a similar role to some of the general thyroid function indices, TSH, anti-TG, anti-TPO, and calcitonin, which can partially distinguish between various thyroid tumors. In conclusion, some of selenium status markers, when accompanied with general parameters, and trace elements can serve as factors with pathophysiologic relevance and be helpful in the identification of malignant disease. Multivariate statistical methods should be employed to tackle a broad array of thyroid tumor diagnostic data in a short time. Partial least squares model and other pattern recognition methods seem to be the most appropriate methods for that task. The miniaturization of all the steps of complex analytical procedure should be developed in a way to allow its completion as sensitive, robust, and efficient for use of the small quantity of material provided by fine-needle biopsy.

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“…As reported by epidemiological, clinical, and experimental studies, the development of thyroid goitres and cancer could be influenced by the environmental excess, deficiency, or imbalance of more than twenty chemical elements (Zaichick et al, 1995;Sin et al, 1992;Kvíčala et al, 1992).…”

Section: Introductionmentioning

confidence: 96%

Non-Essential Trace Elements Dietary Exposure in French Polynesia: Intake Assessment, Nail Bio Monitoring and Thyroid Cancer Risk

Zidane¹,

Ren²,

Xhaard³

et al. 2019

Asian Pac J Cancer Prev

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Background:In French Polynesia, thyroid cancer mortality and incidence is reported to be the highest in the world. Excessive levels of non-essential trace elements (nETE) in the body are associated with several types of cancer.Objective:The present study aims to provide quantitative information on food contamination by mercury (Hg), lead (Pb), arsenic (As) and cadmium (Cd) in French Polynesia and its potential correlation with measurements performed in fingernails of Polynesians, and then to investigate the potential association between these nETE and different thyroid cancer risks. Methods:The study population included 229 interviewed cases and 373 interviewed controls We performed a descriptive analysis of Polynesian food and examined the association between thyroid cancer risk and daily intake levels of nETE and with fingernail nETE levels.Results:Hg contamination was mainly present in sea products, Pb contamination was present in almost all samples, Cd was detectable in starchy food and As was detectable in all sea products. No patient exceeded dietary contamination WHO limits for Pb, 2 participants exceeded it for Hg and 3 individuals (0.5%) for cadmium. In fingernail clippings, the most detectable pollutant was Pb (553 participants), then Hg (543 participants) then Cd (only in 130 participants). Thyroid cancer risk was increased more than 4 times by Pb daily intake in patients with a history of cancer in first-degree relatives than in ones without (p for interaction =0.01), and 2 times more in women with more than 3 pregnancies than in those with none or less (p for interaction =0.005); it was also increased following As intake by more than 30% in patients with a history of cancer in first-degree relatives than in ones without (p for interaction =0.05). Conclusion:Locally produced foods are not a source of nETE exposure in French Polynesia. Dieatry nETE exposure and fingernail nETE concentration are not associated to differentiated thyroid cancer risk. No correlation found between nETE dietary exposure and fingernail nETE concentration.

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Selenium and rubidium changes in subjects with pathologically altered thyroid

Cited by 20 publications

References 18 publications

Comparison of trace element contents in normal thyroid and thyroid with Hashimoto's thyroiditis using neutron activation analysis

Comparison of trace element contents in normal thyroid and thyroid with Hashimoto's thyroiditis using neutron activation analysis

Selenoenzymes, Laboratory Parameters, and Trace Elements in Different Types of Thyroid Tumor

Non-Essential Trace Elements Dietary Exposure in French Polynesia: Intake Assessment, Nail Bio Monitoring and Thyroid Cancer Risk

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