Selenium and tellurium chemistry: historical background

Comasseto, J. V.

doi:10.1590/s0103-50532010001100003

Cited by 26 publications

(21 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Accordingly, additional studies Schiar VPP, Santos DB, Paixão MW, Nogueira CW, Rocha JBT, Zeni G, Human erythrocyte hemolysis induced by selenium and tellurium compounds increased by GSH or glucose: a possible involvement of reactive oxygen species. Chemico-Biological Interactions, 2009;177: 28- (Comasseto et al, 1997;Comasseto, 2010).…”

Section: Discussionmentioning

confidence: 99%

“…Selenium (Se) and Tellurium (Te) belongs to the chalcogen family, sharing similar electronic configuration and some chemical properties with sulfur (S) (Comasseto et al, 1997;Comasseto, 2010). Se has a fundamental role in several living organisms as component of several antioxidant enzymes, including glutathione peroxidase and thioredoxin reductase (Arner et al, 2000;.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Peer Review #1 of "Differential genotoxicity of diphenyl diselenide (PhSe)2 and diphenyl ditelluride (PhTe)2 (v0.1)"

2014

View full text Add to dashboard Cite

Organoselenium compounds have been pointed out as therapeutic agents. In contrast, the potential therapeutic aspects of tellurides have not yet been demonstrated. The present study evaluated the comparative toxicological effects of diphenyl diselenide (PhSe)2 and diphenyl ditelluride (PhTe)2 in mice after in vivo administration. Genotoxicity (as determined by comet assay) and mutagenicicity were used as end-points of toxicity. Subcutaneous administration of high doses of (PhSe)2 or (PhTe)2 (500 mol/Kg) caused distinct genotoxicity in mice. μ (PhSe)2 significantly decreased the DNA damage index after 48 and 96 hours of its injection (p<0.05). In contrast, (PhTe) caused a significant increase in DNA damage (p<0.05) after 48 and 96 hours of intoxication. (PhSe)2 did not cause mutagenicity but (PhTe)2 increased the micronuclei frequency, indicating its mutagenic potential. The present study demonstrated that acute in vivo exposure to ditelluride caused genotoxicity in mice, which may be associated with pro-oxidant effects of diphenyl ditelluride. These results indicated that exposure to ditelluride can be genotoxic to mice and the use of this compound and possibly other related tellurides must be carefully controlled.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Peer Review #1 of "Differential genotoxicity of diphenyl diselenide (PhSe)2 and diphenyl ditelluride (PhTe)2 (v0.1)"

2014

View full text Add to dashboard Cite

show abstract

“…Introduction Selenium (Se) and Tellurium (Te) belongs to the chalcogen family, sharing similar electronic configuration and some chemical properties with sulfur (S) (Comasseto et al, 1997;Comasseto, 2010). Se has a fundamental role in several living organisms as component of several antioxidant enzymes, including glutathione peroxidase and thioredoxin reductase (Arner et al, 2000;Nogueira & Rocha., 2011).…”

Section: Differential Genotoxicity Of Diphenyl Diselenide (Phse)2 Andmentioning

confidence: 99%

“…Furthermore, in view of the genotoxic effect of (PhTe)2, the indication in the literature that organotellurides could be therapeutically active compounds must be revisited taking into consideration the potential toxicity of this element. (Comasseto et al, 1997;Comasseto, 2010).…”

Section: Micronucleus Testmentioning

confidence: 99%

Differential genotoxicity of diphenyl diselenide (PhSe)2 and diphenyl ditelluride (PhTe)2

Rocha

Meinerz

Allebrandt

et al. 2014

Preprint

View full text Add to dashboard Cite

show abstract

“…Apesar de submeter ligações com estereoquímica definida à reações de oxidação, as configurações dos centros foram mantidas, pois o mecanismo de reação proposto 62 , baseia-se em uma etapa-chave onde ocorre um rearranjo do tipo [1,2]-alquil, similar ao que ocorre na reação de Baeyer-Villiger (Esquema 30).…”

Section: Esquema 29unclassified

Organoteluretos vinílicos e alquílicos O-funcionalizados: aplicação na síntese assimétrica de γ-butirolactonas bioativas e feromônios

Ferrarini¹

View full text Add to dashboard Cite

Ao Professor Comasseto, pelas incontáveis oportunidades oferecidas em seu grupo de pesquisa. Hoje saio uma pessoa diferente da que entrou em 2005, pelas coisas que vivenciei em seu laboratório. Agradeço todo o respeito e consideração que sempre teve por mim e desejo o que há de melhor ao senhor. Ao Professor Alcindo, por me ensinar fazer Síntese Orgânica de bancada, pela oportunidade de trabalhar com seu grupo e pelos vários momentos de descontração. Ao meu tio Márcio, por me acomodar em sua casa em São Paulo, em um momento onde eu beirava a exaustão pelas viagens diárias de ida e volta para Jundiaí. Cara, um pedaço disso tudo é seu também. Ao grande amigo Brunão Bassora, por ser um homem exemplar. Mano, obrigado pelas várias cachaças, risadas e momentos inesquecíveis. Se um dia você ler essa tese, saiba que parte dela é sua. Ao grande amigo Rogério Tico, pela amizade, por todos esses anos de convívio, pelos cafés, pelas colaborações, pelas caronas e por muitas outras coisas. Desejo sucesso total para você e para a Lica, vocês são pessoas raras nesse mundo.

show abstract

Selenium and tellurium chemistry: historical background

Abstract: Neste artigo apresentamos um apanhado geral sobre a história da química do selênio e do telúrio no Brasil e no mundo.In this paper we present a general survey on the history of the selenium and tellurium chemistry in Brazil and worldwide.

Cited by 26 publications

References 14 publications

Peer Review #1 of "Differential genotoxicity of diphenyl diselenide (PhSe)2 and diphenyl ditelluride (PhTe)2 (v0.1)"

Peer Review #1 of "Differential genotoxicity of diphenyl diselenide (PhSe)2 and diphenyl ditelluride (PhTe)2 (v0.1)"

Differential genotoxicity of diphenyl diselenide (PhSe)2 and diphenyl ditelluride (PhTe)2

Organoteluretos vinílicos e alquílicos O-funcionalizados: aplicação na síntese assimétrica de γ-butirolactonas bioativas e feromônios

Contact Info

Product

Resources

About