Selenium and vitamin E ameliorate lead acetate-induced hepatotoxicity in rats via suppression of oxidative stress, mRNA of heat shock proteins, and NF-kB production

Mesalam, Noura M.; Ibrahim, Marwa A.; Said, Noha Mohamed

doi:10.1016/j.jtemb.2023.127256

Journal of Trace Elements in Medicine and Biology

2023

DOI: 10.1016/j.jtemb.2023.127256

|View full text |Cite

Selenium and vitamin E ameliorate lead acetate-induced hepatotoxicity in rats via suppression of oxidative stress, mRNA of heat shock proteins, and NF-kB production

Noura M. Mesalam

Marwa A. Ibrahim

Noha Mohamed Said

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

2024

Publication Types

Select...

Article5

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 5 publications

References 91 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Hepatoprotective Effect of Nicotinamide Versus Lead-Motivated Hepatotoxicity in Rats via Correcting Effect on Nuclear Factor-kβ Pathway and Glutathione Metabolism

Mahdavifard,

Shahi

2023

Biol Trace Elem Res

View full text Add to dashboard Cite

Many years ago, until now, lead (Pb) poisoning is one of the pivotal environmental issues. Pb prompts liver dysfunction by elevating in ammation following oxidative stress. Consequently, we for the rst time investigated the effect of nicotinamide (B3) on the rat's liver histopathological and biochemical pro les in a rat model of Pb toxicity. Materials and MethodsThirty-six rats were shared into four groups (nine rats in each): untreated normal (N), B3 treated normal (N-B3), lead toxicity (Pbt), and B3 lead toxicity (Pbt-B3). Treated groups took B3 (180 mg/L in drinking water for one month). Pb intoxication was motivated in rats by acquiring 50 mg/l lead acetate from drinking water. Oxidative stress markers (advanced protein oxidation products, and malondialdehyde), antioxidant markers (total glutathione, reduced (GSH) to oxidized (GSSG) glutathione ratio, ferric ion reducing power, catalase, and paraoxonase-1), and in ammatory markers (hepatic nuclear factor-kβ expression, interleukin 1β level, and myeloperoxidase activity) in sera and liver homogenates were determined. Further, Biochemical liver function indicators (Alanine transaminase, aspartate transaminase, alkaline phosphatase, gamma-glutamyl transpeptidase, total bilirubin, total protein, albumin, and globulins) were quanti ed. Pb-induced liver damage was assessed with Histopathological observation.Results: B3 corrected lead-persuaded biochemical and histopathological changes in the rat's liver. In addition, treatment diminished Pb, oxidative stress, and in ammatory markers in the sera and liver homogenates of N-B3 and Pbt-B3 groups as well as elevated antioxidant markers (p < 0.001). ConclusionsNicotinamide through a decrease in Pb, oxidative stress, and in ammation prevented Pb prompted liver histopathological alternations and reduced liver dysfunction parameters.

show abstract

Hepatoprotective Effect of Nicotinamide Versus Lead-Motivated Hepatotoxicity in Rats via Correcting Effect on Nuclear Factor-kβ Pathway and Glutathione Metabolism

Mahdavifard,

Shahi

2023

Biol Trace Elem Res

View full text Add to dashboard Cite

show abstract

The protective effects of selenium and boron on cyclophosphamide-induced hepatic oxidative stress, inflammation, and apoptosis in rats

Cengiz,

Gür,

Gür

et al. 2024

Heliyon

View full text Add to dashboard Cite

Chitosan-encapsulated selenium nanoparticles alleviate CCl4 induced hepatotoxicity through synergistically modulating NF-κB and Nrf2 signaling pathways and regulating Bcl-2 and Caspase-3 expression: A comprehensive study with multiple regression analysis

Mrwad,

El-Shafey,

Said

2024

Journal of Trace Elements in Medicine and Biology

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Selenium and vitamin E ameliorate lead acetate-induced hepatotoxicity in rats via suppression of oxidative stress, mRNA of heat shock proteins, and NF-kB production

Cited by 5 publications

References 91 publications

Hepatoprotective Effect of Nicotinamide Versus Lead-Motivated Hepatotoxicity in Rats via Correcting Effect on Nuclear Factor-kβ Pathway and Glutathione Metabolism

Hepatoprotective Effect of Nicotinamide Versus Lead-Motivated Hepatotoxicity in Rats via Correcting Effect on Nuclear Factor-kβ Pathway and Glutathione Metabolism

The protective effects of selenium and boron on cyclophosphamide-induced hepatic oxidative stress, inflammation, and apoptosis in rats

Chitosan-encapsulated selenium nanoparticles alleviate CCl4 induced hepatotoxicity through synergistically modulating NF-κB and Nrf2 signaling pathways and regulating Bcl-2 and Caspase-3 expression: A comprehensive study with multiple regression analysis

Contact Info

Product

Resources

About