Selenium and zinc protect brain mitochondrial antioxidants and electron transport chain enzymes following postnatal protein malnutrition

Adebayo, Olusegun L.; Adenuga, Gbenga A.; Sandhir, Rajat

doi:10.1016/j.lfs.2016.03.008

Cited by 29 publications

(18 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The findings of this study are in agreement with other studies and could explain the neurotoxic effects of AFB1 ( 21 , 24 , 47 , 48 ). In addition, low protein diet has been shown to increase oxidative stress in different parts of the brain thereby resulting in cognitive dysfunction ( 49 , 50 ).…”

Section: Discussionmentioning

confidence: 99%

Oxidative Stress in Extrahepatic Tissues of Rats Co-Exposed to Aflatoxin B1 and Low Protein Diet

Rotimi

Oluwafemi

et al. 2018

ToxicolRes

View full text Add to dashboard Cite

Early life exposure to aflatoxin B1 (AFB1) and low protein diet through complementary foods during weaning is common in parts of Africa and Asia. This study evaluated the effect of co-exposure to AFB1 and low protein diet on the extrahepatic tissues of rats. Twenty-four three-week old weanling male albino rats were used for this study and were randomly assigned into four groups: group 1 served as control and was fed normal protein diet (20% protein), group 2 was fed low protein diet (5% protein), group 3 was fed normal protein diet + 40 ppb AFB1 while group 4 received low protein diet + 40 ppb AFB1, all for eight weeks. Afterward, biomarkers of anemia (packed cell volume (PCV), hemoglobin) and kidney function (urea, uric acid, and creatinine) were determined in the blood while biomarkers of oxidative stress were determined in the tissues spectrophotometrically. Co-exposure to AFB1 and low protein diet significantly (p < 0.05) decreased body weight gain and PCV, increased biomarkers of kidney functions and induced oxidative stress in the tissues studied. There was significant (p < 0.05) reduction in glutathione concentration while TBARS was significantly increased in the tissues. Co-exposure to AFB1 and low protein diet had additive effects on decreasing the weight gain and potentiation effect of kidney dysfunction in the rats. The co-exposure also decreased antioxidant enzymes and increased oxidant status in the tissues. Our results demonstrate that this co-exposure has deleterious health effects on extrahepatic tissues and should be a public health concern especially in developing countries where AFB1 contamination is common.

show abstract

Section: Discussionmentioning

confidence: 99%

Oxidative Stress in Extrahepatic Tissues of Rats Co-Exposed to Aflatoxin B1 and Low Protein Diet

Rotimi

Oluwafemi

et al. 2018

ToxicolRes

View full text Add to dashboard Cite

show abstract

“…We earlier reported that low dietary protein enhances the high level of free radicals in the brain of PU rats [4][5][6]40] . Therefore, the suggested reason for the increase in cholesterol levels in the cortex and cerebellum of PU rats as observed in this study could be related to increased expression of 3-hydroxy-3-methylglutaryl CoA reductase (HMGCR).…”

Section: Discussionmentioning

confidence: 95%

“…The results of this study favoured the reports of Du et al [36] and Kerr and Helmuth [37] , as there were significant increases in both the total lipids and cholesterol of PU rats compared to the controls. In this study, the deficiency of protein in the prepared PU diet was augmented with more carbohydrate compared to the APD [40] . It has been established that low dietary protein increases fat content because the excess carbohydrate consumed relative to protein is stored as lipid [41] .…”

Section: Discussionmentioning

confidence: 99%

Dietary Selenium or Zinc Supplementation Restores Brain Lipid Composition and Membrane Fluidity in Protein-Undernourished Rats

Adebayo

Salau²,

Sandhir³

et al. 2016

Dev Neurosci

Self Cite

View full text Add to dashboard Cite

Studies have shown that protein undernutrition (PU) modifies the membrane lipid composition in the intestine and liver, as well as in plasma and other areas. However, there is limited information on the effect of PU on synaptosomal membrane lipid composition and fluidity and the protective role of selenium (Se) and zinc (Zn), which is a major focus of the present study. For 10 weeks, rats were fed diets containing 16% casein, which constituted the adequate protein diet, or 5% casein, representing the PU diet. The animals were supplemented with Se and Zn at a concentration of 0.15 and 227 mg L^-1, respectively, in drinking water for 3 weeks. The results showed a significant increase in total lipids, glycolipids, triglycerides, cholesterol, and the cholesterol/phospholipid (Chol/PL) ratio, and a significant reduction in phospholipids and membrane fluidity. Se and Zn supplementation to PU rats, however, significantly lowered total lipids, glycolipids, triglycerides, cholesterol, and the Chol/PL ratio, while phospholipids and membrane fluidity were significantly restored. It is concluded that a perturbed lipid composition induced by PU affects the membrane structure and fluidity, which in turn influences membrane functions. The study suggests that Se and Zn supplementation might be beneficial in restoring the lipid dyshomeostasis associated with PU.

show abstract

“…The main cause of damage to liver, kidney and muscle caused by selenium deficiency is related to the weakening of antioxidant systems [52,53]. Excessive accumulation of oxygen-free radicals in the organism causes a decrease in and conformational changes to cell mitochondrial membrane-bound enzymes, cytochrome C oxidase (CCO) and cardiolipin (CL), resulting in decreased activities of mitochondrial respiratory chain and mitochondrial energy conversion disturbance [54][55][56][57][58]. Dysfunction and inhibition of mitochondrial ATP synthesis, structural denaturation and dysfunction of contractile proteins, and peroxidation of cell membranes, etc.…”

Section: Discussionmentioning

confidence: 99%

Effects of Selenium Deficiency in the Environment on Antioxidant Systems of Wumen Semi-Fine Wool Sheep

Huo¹,

Wu²,

Song³

et al. 2020

Pol. J. Environ. Stud.

View full text Add to dashboard Cite

The Wumeng semi-fine wool sheep industry is the pillar industry in the Wumeng mountainous area. The objective of this study was to explore the effects of selenium deficiency in the environment on the mineral element metabolism and antioxidant system function in grazing Wumen semi-fine wool sheep, and provide scientific and objective data for the reference of the development of Wumen sheep industry. Samples of soil and forage were collected from affected and unaffected areas. Samples of tissue and blood were collected from affected and healthy sheep. The samples were used for hematological parameters and biochemical index analyses and mineral nutrient measurements. The results showed that concentrations of selenium (Se) in the soil and forage samples from the affected area were significantly lower than those from the unaffected area (P<0.01). The selenium concentrations of blood, liver and wool samples from the affected sheep were significantly lower than those in the healthy sheep (P<0.01). Hb, PCV and MCH of the affected sheep were significantly lower than those in the healthy sheep (P<0.01). Serum GSH-PX, CAT and T-AOC of the affected sheep were significantly lower than those in the healthy sheep (P<0.01). Serum MDA, T-NOS, NO and LPO of the affected sheep were significantly higher than those in the healthy sheep (P < 0.01). Serum AKP, CPK, LDH, ALT, AST and A/G value of the affected sheep were significantly higher than those in the healthy sheep (P<0.01). Serum total protein, albumin, α-Globulin, β-Globulin and γ-Globulin concentrations of the affected sheep were significantly lower than those in the healthy sheep (P<0.01). The study clearly demonstrated that grazing a seleniumdeficient meadow significantly reduces the selenium content of tissue and antioxidant capacity, which seriously caused oxidative damage of the Wumeng semi-fine wool sheep.

show abstract

Selenium and zinc protect brain mitochondrial antioxidants and electron transport chain enzymes following postnatal protein malnutrition

Cited by 29 publications

References 68 publications

Oxidative Stress in Extrahepatic Tissues of Rats Co-Exposed to Aflatoxin B1 and Low Protein Diet

Oxidative Stress in Extrahepatic Tissues of Rats Co-Exposed to Aflatoxin B1 and Low Protein Diet

Dietary Selenium or Zinc Supplementation Restores Brain Lipid Composition and Membrane Fluidity in Protein-Undernourished Rats

Effects of Selenium Deficiency in the Environment on Antioxidant Systems of Wumen Semi-Fine Wool Sheep

Contact Info

Product

Resources

About