Selenium attenuates apoptosis and p-AMPK expressions in fluoride-induced NRK-52E cells

Gao, Jinliang; Wang, Yu; Xu, Guoqiang; Wei, Jianing; Chang, Kai; Tian, Xiaolin; Liu, Maolin; Yan, Xiaoyan; Huo, Meijun; Song, Guohua

doi:10.1007/s11356-019-04855-2

Cited by 14 publications

(1 citation statement)

References 57 publications

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“…Previous study indicated that almost 19 million people suffered from uorosis, of which the skeletal uorosis has a icted about 1.2 million people in China caused mainly by uoride from coal-burning [35], which also disturb crops and livestock sector. Long-term consumption of food or water with high uoride content will also cause chronic poisoning of uorine (in ammation and degeneration of kidney, liver, intestine, brain, and lung) [9]. Among them, uoride has toxic effect on the liver, so excessive intake of uoride can lead to extensive degenerative changes in the liver ultimately reduce its detoxi cation function.…”

Section: Introductionmentioning

confidence: 99%

Ameliorative Effects of Nano-Selenium Against Fluoride Stress Induced Hepatocytes Autophagy and Apoptosis in Mice

Wang

Liu

Han

et al. 2020

Preprint

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Background: Fluorine is widespread in the environment, and the injurious impacts of fluoride underscore its significance for public health. The long-term presence of fluorine in environment could be a risk in hepatotoxicity for both human beings and animals. Important role of selenium in mitigation of heavy metal toxicity via regulating autophagy and apoptosis is well-known. Further, nano-Se is a common artificial nano material, with higher biological activity and lower toxicity. The aim of the current study was to examine whether nano-Se supplementation can reduce the effects of fluoride-induced hepatocytes autophagy and apoptosis. Results: Here, we report that fluoride exposure induces apoptosis and autophagy with nucleus broken, dissolved and disappeared of hepatocyte, contributing to its hepatotoxicity. More importantly, Cyt-C and Beclin-1/Bcl-2 pathways are involved in the regulation of autophagy and apoptosis via targeting Caspase-9, Caspase-3, P53, Bax, LC3, ATG-5, P62 and mTOR expressions. Conclusion: Nano-Se is capable to alleviate fluoride-induced hepatocyte damage, that selenium can be prefer to prevent chronic fluorosis-induced autophagy and apoptosis by regulating Cyt-C and Beclin-1/Bcl-2 signaling pathway. In precisely, NaF-induced the liver injury by activating autophagy and apoptosis, which indicate that fluorine exposure, pose an ecological risk to human beings and animals. Nano-Se has protective effects against fluoride-induced hepatocytes.

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Section: Introductionmentioning

confidence: 99%

Ameliorative Effects of Nano-Selenium Against Fluoride Stress Induced Hepatocytes Autophagy and Apoptosis in Mice

Wang

Liu

Han

et al. 2020

Preprint

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Enhancement of the Mechanical Properties and Biological Performance of Hydroxyapatite Coating by Selenium and Fluorine Ion Codoping

Zhang,

Bai,

et al. 2024

Adv Eng Mater

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Ion doping is a feasible method to improve the mechanical and biological properties of hydroxyapatite (HA) as an implant coating material. F and Se codoped HA (SeF‐HA) powder is synthesized with the method of chemical codeposition and directly used for coating preparation via suspension plasma spray technology. Various characterizations indicate that F and Se ions have been codoped into the HA structure by substituting OH− and PO43− groups, respectively. The SeF‐HA coatings exhibit excellent adhesion strength with the substrate, fully meeting the ISO requirement of 15 MPa. The dissolution behavior is investigated by immersing the coatings in simulated body fluid for different durations. The results show that the dissolution rate of the SeF‐HA coatings is lower than that of the single Se‐doped HA coating, suggesting an improvement in the stability of the SeF‐HA coating. The in vitro studies show that the SeF‐HA coating can promote the osteogenic activity of osteoblasts and has an antiproliferative effect on osteosarcoma cells. Based on these results, it can be concluded that the combined effects of Se and F can make suspension plasma sprayed HA coating a potential coating material for dental implants or for bone tissue repair in osteosarcoma patients.

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Recent advances in cellular effects of fluoride: an update on its signalling pathway and targeted therapeutic approaches

Nagendra

Bose

2021

Mol Biol Rep

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Selenium attenuates apoptosis and p-AMPK expressions in fluoride-induced NRK-52E cells

Cited by 14 publications

References 57 publications

Ameliorative Effects of Nano-Selenium Against Fluoride Stress Induced Hepatocytes Autophagy and Apoptosis in Mice

Ameliorative Effects of Nano-Selenium Against Fluoride Stress Induced Hepatocytes Autophagy and Apoptosis in Mice

Enhancement of the Mechanical Properties and Biological Performance of Hydroxyapatite Coating by Selenium and Fluorine Ion Codoping

Recent advances in cellular effects of fluoride: an update on its signalling pathway and targeted therapeutic approaches

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