Selenium concentrations in blood and serum from patients with mental diseases

Alertsen, Aase Rye; Aukrust, A.; Skaug, O. E.

doi:10.1111/j.1600-0447.1986.tb10608.x

Cited by 18 publications

(5 citation statements)

References 5 publications

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“…Tada et al (1986) found elevated levels of selenium in the hair of male, but not female, patients. Alertsen et al (1986) found that serum and blood selenium levels in a group of Norwegians with schizophrenia was no different from those in normal subjects. However, if schizophrenia results from a prenatal or childhood exposure, the significance of selenium studies in adults with schizophrenia is questionable.…”

Section: Association Between Selenium Deficiency and Schizophreniamentioning

confidence: 83%

Role of Selenium and Other Trace Elements in the Geography of Schizophrenia

Brown¹

1994

Schizophrenia Bulletin

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Medical geology is the application of trace element geography to epidemiology. This approach is used to compare the geographic distribution of selenium and other trace elements in soil and food with that of high schizophrenia rates in the United States and other countries. Since the comparison is most statistically significant for low selenium, the selenium theory of schizophrenia is evaluated by the principles of environmental epidemiology. Although this examination finds the theory deficient, research questions are generated to test the theory further and to investigate the causes of schizophrenia.

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Section: Association Between Selenium Deficiency and Schizophreniamentioning

confidence: 83%

Role of Selenium and Other Trace Elements in the Geography of Schizophrenia

Brown¹

1994

Schizophrenia Bulletin

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“… 46 , 47 , 48 , 49 , 50 , 51 It is of note that Se deficiency has been associated with higher rates of schizophrenia 52 , 53 and some studies have shown lower plasma Se concentrations in patients with schizophrenia, 54 , 55 whereas others showed that Se is unchanged in the blood and serum of patients. 56 , 57 Thus, it would be beneficial to determine the Se concentrations in CNS regions in subjects with schizophrenia to ascertain whether there is a link between Se levels and SELENBP1 expression. The inverse relationship demonstrated between SELENBP1 expression and cell growth, 58 , 59 and the observed association of SELENBP1 with neuronal cell outgrowth, 3 suggests that changes in central SELENBP1 could be linked to aberrant cell growth in the brains of people with schizophrenia; 60 , 61 , 62 however, more detailed studies are needed to determine its exact function in the CNS and its implications in disease aetiology.…”

Section: Discussionmentioning

confidence: 99%

SELENBP1 expression in the prefrontal cortex of subjects with schizophrenia

et al. 2015

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Selenium binding protein 1 (SELENBP1) messenger RNA (mRNA) has previously been shown to be upregulated in the brain and blood from subjects with schizophrenia. We aimed to validate these findings in a new cohort using real-time PCR in Brodmann's Area (BA) 9, and to determine the disease specificity of increased SELENBP1 expression by measuring SELENBP1 mRNA in subjects with major depressive disorder and bipolar disorder. We then extended the study to include other cortical regions such as BA8 and BA44. SELENBP1 mRNA was higher in BA9 (P=0.001), BA8 (P=0.003) and BA44 (P=0.0007) from subjects with schizophrenia. Conversely, in affective disorders, there was no significant difference in SELENBP1 mRNA in BA9 (P=0.67), suggesting that the upregulation may be diagnosis specific. Measurement of SELENBP1 protein levels showed that changes in mRNA did not translate to changes in protein. In addition, chronic treatment of rats with antipsychotics did not significantly affect the expression of Selenbp1 in the cortex (P=0.24). Our data show that elevated SELENBP1 transcript expression is widespread throughout the prefrontal cortex in schizophrenia, and confirm that this change is a consistent feature of schizophrenia and not a simple drug effect.

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“…This particular product is from a Jamaican weed Eupatorium riparium Regel. Ageratochromene 4 is the 2 H -chromene derivative, isolated from Ageratum mexicanum Sims, − Aggeratum conyzoides L., and Ageratum houstonianum Mill. , …”

Section: Natural Chromenes and Fused-chromenesmentioning

confidence: 99%