Selenium-Containing Amino Acids Protect Dextran Sulfate Sodium-Induced Colitis via Ameliorating Oxidative Stress and Intestinal Inflammation

Shi, Chengxin; Yue, Fengli; Shi, Feiyu; Qin, Qian; Wang, Lizhao; Wang, Guanghui; Mu, Lijun; Liú, Dan; Li, Yaguang; Yu, Tianyu; She, Junjun

doi:10.2147/jir.s288412

Cited by 40 publications

(19 citation statements)

References 44 publications

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“…In contrast, these increases were reversed by the STV-Na treatment. These data are consistent with those reported by Shi et al [ 39 ] and suggest that STV-Na possesses protective properties against colitis that are likely due to its anti-inflammatory and antioxidant effects.…”

Section: Discussionsupporting

confidence: 93%

Isosteviol Sodium Ameliorates Dextran Sodium Sulfate-Induced Chronic Colitis through the Regulation of Metabolic Profiling, Macrophage Polarization, and NF-κB Pathway

Wang

Huang

Tan

et al. 2022

Oxidative Medicine and Cellular Longevity

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Inflammatory bowel diseases (IBDs) constitute a group of chronic intestinal conditions prominently featuring deranged metabolism. Effective pharmacological treatments for IBDs are lacking. Isosteviol sodium (STV-Na) exhibits anti-inflammatory activity and may offer therapeutic benefits in chronic colitis. However, the associated mechanism remains unclear. This study is aimed at exploring the therapeutic effects of STV-Na against chronic colitis in terms of metabolic reprogramming and macrophage polarization. Results show that STV-Na attenuated weight loss and colonic pathological damage and restored the hematological and biochemical parameters in chronic colitis mice models. STV-Na also restored intestinal permeability by increasing the goblet cell numbers, which was accompanied by lowered plasma lipopolysaccharide and diamine oxidase levels. Metabolomic analysis highlighted 102 candidate biomarkers and 5 vital pathways that may be crucial in the potential pharmacological mechanism of STV-Na in regulating intestinal inflammation and oxidative stress. These pathways were glycerophospholipid metabolism, phenylalanine metabolism, phenylalanine, tyrosine and tryptophan biosynthesis, the pentose phosphate pathway, and phosphonate and phosphinate metabolism. Furthermore, STV-Na significantly decreased M1 macrophage polarization in the spleen and colon. The mRNA and protein levels of IL-1β, TNF-α, and NF-κB/p65 in colonic tissue from the colitis mice were decreased after the STV-Na treatment. Overall, STV-Na could alleviate chronic colitis by suppressing oxidative stress and inflammation levels, reprogramming the metabolic profile, inhibiting macrophage polarization, and suppressing the NF-κB/p65 signaling pathway. STV-Na remains a promising candidate drug for treating IBDs.

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Section: Discussionsupporting

confidence: 93%

Isosteviol Sodium Ameliorates Dextran Sodium Sulfate-Induced Chronic Colitis through the Regulation of Metabolic Profiling, Macrophage Polarization, and NF-κB Pathway

Wang

Huang

Tan

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…These Se-containing small compounds could be metabolized to selenoproteins, including GPx, thioredoxin reductase (TXNRD 1 to 3), and methionine sulfoxide reductase (Msr), which could protect cells from harmful oxidative free radicals and reduce colonic inflammation ( 41 ). Moreover, our previous reports have demonstrated that selenium supplement in the DSS-challenged murine model could alleviate colonic inflammation, which is consistent with the therapeutic effects observed for our diselenide-bridged MSNs in this study ( 42 ). The increased infiltrations of T reg cells in the colonic tissue of DSS-challenged mice support the unique advantages of MON-PEI against IBD by regulating multiple immune cells.…”

Section: Discussionsupporting

confidence: 92%

A nanoparticulate dual scavenger for targeted therapy of inflammatory bowel disease

et al. 2022

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A therapeutic strategy that targets multiple proinflammatory factors in inflammatory bowel disease (IBD) with minimal systemic side effects would be attractive. Here, we develop a drug-free, biodegradable nanomedicine that acts against IBD by scavenging proinflammatory cell-free DNA (cfDNA) and reactive oxygen species (ROS). Polyethylenimine (PEI) was conjugated to antioxidative diselenide-bridged mesoporous organosilica nanoparticles (MONs) to formulate nanoparticles (MON-PEI) that exhibited high cfDNA binding affinity and ROS-responsive degradation. In ulcerative colitis and Crohn’s disease mouse colitis models, orally administered MON-PEI accumulated preferentially in the inflamed colon and attenuated colonic and peritoneal inflammation by alleviating cfDNA- and ROS-mediated inflammatory responses, allowing a reduced dose frequency and ameliorating colitis even after delayed treatment. This work suggests a new nanomedicine strategy for IBD treatment.

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“…This phenomenon occurs in all organisms. Increased oxidative stress can cause cellular and tissue damage, which results in the inability to resolve the inflammatory response, thereby leading to a chronic inflammatory state ( 4 ). Several pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-α and interleukin (IL)-6, affect the systemic inflammatory reaction either directly or indirectly ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Shrimp Peptide on Dextran Sulfate Sodium-Induced Colitis in Mice

et al. 2021

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Inflammatory bowel disease, an intestinal relapsing inflammatory disease, not only impairs gastrointestinal function but also increases the chances of developing colon cancer. Currently, the effects of shrimp peptide (SP) in mice model of ulcerative colitis (UC) are still unclear. In particular, it is uncertain whether SP affects the gut flora with UC mice. In this study, we investigated the anti-inflammatory effects of SP on a dextran sulfate sodium (DSS)-induced mouse model of UC. Firstly, the molecular weight of SP was mainly distributed in the range of 180–1,000 Da (61.95% proportion), and the amino acid composition showed that SP contained 17 amino acids, of which, the essential amino acids accounted for 54.50%. In vivo, oral SP significantly attenuated the severity of colitis, such as diarrhea, weight loss, and rectal bleeding. Furthermore, treatment with SP remarkably ameliorated intestinal barrier integrity, thus lowering the levels of the inflammatory cytokines and ameliorating antioxidant indices and intestinal injury indicators in the serum and colon. Lastly, the cecal contents were used to sequence and analyze the 16S rRNA genes of bacteria. Results suggested that treatment with SP could restore the balance of intestinal flora in modeled mice by regulating the abundance of pathogenic and beneficial bacteria. Furthermore, SP could significantly improve intestinal flora dysfunction in mice with UC. In summary, our findings show that SP has a prophylactic and therapeutic effect in UC in vivo, thereby highlighting its broad medicinal applications.

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Selenium-Containing Amino Acids Protect Dextran Sulfate Sodium-Induced Colitis via Ameliorating Oxidative Stress and Intestinal Inflammation

Cited by 40 publications

References 44 publications

Isosteviol Sodium Ameliorates Dextran Sodium Sulfate-Induced Chronic Colitis through the Regulation of Metabolic Profiling, Macrophage Polarization, and NF-κB Pathway

Isosteviol Sodium Ameliorates Dextran Sodium Sulfate-Induced Chronic Colitis through the Regulation of Metabolic Profiling, Macrophage Polarization, and NF-κB Pathway

A nanoparticulate dual scavenger for targeted therapy of inflammatory bowel disease

Protective Effects of Shrimp Peptide on Dextran Sulfate Sodium-Induced Colitis in Mice

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