Selenium Containing Compounds from Poison to Drug Candidates: A Review on the GPx-like Activity

Santi, Claudio; Tidei, Caterina; Scalera, Claudia; Piroddi, Marta; Galli, Francesco

doi:10.2174/2212796811307010003

Cited by 99 publications

(49 citation statements)

References 67 publications

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“…2,5,6 Our longtime interest in the study of the reactivity of silylchalcogenides led us to discover synthetic routes to access several classes of novel sulfur-and selenium-containing organic compounds.…”

Section: 2mentioning

confidence: 99%

Novel sulfur and selenium-containing antioxidants: Synthesis and evaluation of their GPx-like activity

Tanini

D'Esopo

Chen

et al. 2016

Phosphorus, Sulfur, and Silicon and the Related Elements

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New linear and cyclic chalcogen-containing compounds have been synthesized exploiting the reactivity of bis(trimethylsilyl)selenide with strained heterocycles. A simple and efficient procedure allowed a selective access to β-functionalized selenides, diselenides, and dithiaselenepanes under mild conditions. Antioxidant catalytic activity of these compounds was investigated in the reaction of hydrogen peroxide with dithiothreitol (DTT red ). According to this assay, some of the synthesized structures exhibited a remarkable glutathione peroxidase (GPx)-like activity.

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Section: 2mentioning

confidence: 99%

Novel sulfur and selenium-containing antioxidants: Synthesis and evaluation of their GPx-like activity

Tanini

D'Esopo

Chen

et al. 2016

Phosphorus, Sulfur, and Silicon and the Related Elements

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“…Se plays an important role in preventing the formation of free radicals especially reactive oxygen species (ROS) (Loef, Schrauzeer, & Walach, 2011;Santi, Tidei, Scalera, Piroddi, & Galli, 2013). Therefore, Se supplementation is very important.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, and controlled release of selenium nanoparticles stabilized by chitosan of different molecular weights

Zhang

Zhai

Zhao

et al. 2015

Carbohydrate Polymers

161

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“…The reaction mixture was stirred at room temperature for 20 h. The separated precipitate was purified on silica gel column chromatography (230-400 mesh) using (dichloromethane/methanol, 90:10, R f ¼ 0.74) to afford the desired product: 0. 30 …”

Section: -(4-mentioning

confidence: 99%

“…Selenium atom is also included in very important components of the human body such as selenoproteins 29 , and glutathione peroxidase-a key enzyme in antioxidant defense 30 . One of the most well known anti-cancer drugs containing a selenium atom is selenazofurin (2-b-Dribofuranosylselenazole-4-carboxamide), five to ten times more potent in in vitro and in vivo anti-tumor screenings than thiazofurin 31 .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, antimicrobial and anticonvulsant screening of small library of tetrahydro-2H-thiopyran-4-yl based thiazoles and selenazoles

Łączkowski

Biernasiuk

Baranowska-Łączkowska

et al. 2016

Journal of Enzyme Inhibition and Medicinal Chemistry

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Synthesis and investigation of antimicrobial activity of 22 novel thiazoles and selenazoles derived from dihydro-2H-thiopyran-4(3H)-one are presented. Additionally, anticonvulsant activity of six derivatives is examinated. Among the derivatives, compounds 4a-f, 4i, 4k, 4 l, 4n, 4o-s and 4v have very strong activity against Candida spp. with MIC ¼ 1.95-15.62 mg/ml. In the case of compounds 4a-f, 4i, 4k, 4 l, 4n, 4o, 4r and 4s, the activity is very strong against some strains of Candida spp. isolated from clinical materials, with MIC ¼ 0.98 to 15.62 mg/ml. Additionally, compounds 4n-v are found to be active against Gram-positive bacteria with MIC ¼ 7.81-62.5 mg/ml. The results of anticonvulsant screening reveal that compounds 4a, 4b, 4m and 4n demonstrate a statistically significant anticonvulsant activity in the pentylenetetrazole model, whereas compounds 4a and 4n showed protection in 6-Hz psychomotor seizure model. Noteworthy, none of these compounds impaired animals' motor skills in the rotarod test. We also performed quantum chemical calculation of interaction and binding energies in complex of 4a with cyclodextrin.

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Selenium Containing Compounds from Poison to Drug Candidates: A Review on the GPx-like Activity

Cited by 99 publications

References 67 publications

Novel sulfur and selenium-containing antioxidants: Synthesis and evaluation of their GPx-like activity

Novel sulfur and selenium-containing antioxidants: Synthesis and evaluation of their GPx-like activity

Synthesis, characterization, and controlled release of selenium nanoparticles stabilized by chitosan of different molecular weights

Synthesis, antimicrobial and anticonvulsant screening of small library of tetrahydro-2H-thiopyran-4-yl based thiazoles and selenazoles

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