Selenium deficiency as a consequence of human activity and its correction

Ermakov, V. V.; Jovanović, Larisa

doi:10.1016/j.gexplo.2010.07.004

Cited by 26 publications

(12 citation statements)

References 19 publications

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“…These changes may lead to nutritional effects on immunity that are not related to energy restriction. One of the most researched minerals in this context is selenium, which is decreasing in bioavailability due to anthropogenic causes such as fossil fuel combustion and intensified agriculture . Selenium has been linked to immune function in ruminants , where it is important in oxidative immunity, foetal development, muscle maintenance and bone metabolism .…”

Section: A New Frontier: How Will Anthropogenic Environmental Change mentioning

confidence: 99%

“…In addition to selenium, mammalian tissues contain more than 50 other minerals, several of which also play a role in immunity. Zinc, iron, copper, cobalt and molybdenum have been linked directly to altered immune function in livestock and are all altered during climate change or land use change such as intensified agriculture .…”

Section: A New Frontier: How Will Anthropogenic Environmental Change mentioning

confidence: 99%

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Beyond mice and men: environmental change, immunity and infections in wild ungulates

Jolles

Beechler

Dolan

2015

Parasite Immunology

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In the face of rapid environmental change, anticipating shifts in microparasite and macroparasite dynamics, including emergence events, is an enormous challenge. We argue that immunological studies in natural populations are pivotal to meeting this challenge: Many components of environmental change – shifts in biotic assemblages, altered climate patterns, and reduced environmental predictability – may affect host immunity. We suggest that wild ungulates can serve as model systems aiding the discovery of immunological mechanisms that link environmental change with parasite transmission dynamics. Our review of eco-immunological studies in wild ungulates reveals progress in understanding how co-infections affect immunity and parasite transmission; and how environmental and genetic factors interact to shape immunity. Changes in bioavailability of micronutrients have been linked to immunity and health in wild ungulates. Although physiological stress in response to environmental change has been assessed, downstream effects on immunity have not been studied. Moreover, the taxonomic range of ungulates studied is limited to bovids (bighorn sheep, Soay sheep, chamois, musk oxen, bison, African buffalo) and a few cervids (red deer, black-tailed deer). We discuss areas where future studies in ungulates could lead to significant contributions in understanding patterns of immunity and infection in natural populations and across species.

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Section: A New Frontier: How Will Anthropogenic Environmental Change mentioning

confidence: 99%

Section: A New Frontier: How Will Anthropogenic Environmental Change mentioning

confidence: 99%

Beyond mice and men: environmental change, immunity and infections in wild ungulates

Jolles

Beechler

Dolan

2015

Parasite Immunology

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“…The cumulative incidence of the primary outcome was estimated with the use of the Kaplan-Meier method; hazard ratios and 95% confidence interval was estimated with the use of Cox regression models, stratified according to selenium supplementation excessive oxidative stress, myocardial damage and PPCM. Selenium deficiency can also impair many other biologic functions, including those of skeletal muscles, and endocrine and immune systems [15,16]. Although the effect of selenium on skeletal muscle function was beyond the scope of our study, it is conceivable that it was the direct effect of the selenium supplementation on skeletal muscle function that led to the improvement of symptoms in the present study.…”

Section: Discussionmentioning

confidence: 70%

Selenium Supplementation in Patients With Peripartum Cardiomyopathy: A Proof-of-Concept Trial

Karaye¹,

Sa'du²,

Ishaq³

et al. 2020

Journal of the American College of Cardiology

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Background: We studied the efficacy and safety of selenium supplementation in patients who had peripartum cardiomyopathy (PPCM) and selenium deficiency. Methods: We randomly assigned 100 PPCM patients with left ventricular ejection fraction (LVEF) < 45% and selenium deficiency (< 70 μg/L) to receive either oral Selenium (L-selenomethionine) 200 μg/day for 3 months or nothing, in addition to recommended therapy, in an open-label randomised trial. The primary outcome was a composite of persistence of heart failure (HF) symptoms, unrecovered LV systolic function (LVEF < 55%) or death from any cause. Results: Over a median of 19 months, the primary outcome occurred in 36 of 46 patients (78.3%) in the selenium group and in 43 of 54 patients (79.6%) in the control group (hazard ratio [HR] 0.69; 95% confidence interval [CI] 0.43-1.09; p = 0.113). Persistence of HF symptoms occurred in 18 patients (39.1%) in the selenium group and in 37 patients (68.5%) in the control group (HR 0.53; 95% CI 0.30-0.93; p = 0.006). LVEF < 55% occurred in 33 patients (71.7%) in the selenium group and in 38 patients (70.4%) in the control group (HR 0.91; 95% CI 0.57-1.45; p = 0.944). Death from any cause occurred in 3 patients (6.5%) in the selenium group and in 9 patients (16.7%) in the control group (HR 0.37; 95% CI 0.10-1.37; p = 0.137). Conclusions: In this study, selenium supplementation did not reduce the risk of the primary outcome, but it significantly reduced HF symptoms, and there was a trend towards a reduction of all-cause mortality. Clinical trial registration: ClinicalTrials.gov Identifier: NCT03081949.

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“…In Russia, the general strategy of selenium status optimization for the population has not yet been devel oped [9]. In most regions of Siberia and the Far East, the import of agricultural products with a high selenium content is the major factor of the influence on the sele nium status of the population.…”

Section: Resultsmentioning

confidence: 99%

Selenium status of Omsk oblast

Golubkina

Sindereva

Zaiko

et al. 2012

Contemp. Probl. Ecol.

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For 32 districts of Omsk oblast, the levels of selenium accumulation were determined across trophic levels: soil, plants, animals, and human. An inverse correlation was found between serum selenium concentration and parameters of total mortality, as well as the incidence of lung, ovarian, and rectal cancer. Significant differences were shown in the coefficient of plant selenium accumulation depending on the soil type. We discuss the most promising approaches to optimizing the selenium status of the population.

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Selenium deficiency as a consequence of human activity and its correction

Cited by 26 publications

References 19 publications

Beyond mice and men: environmental change, immunity and infections in wild ungulates

Beyond mice and men: environmental change, immunity and infections in wild ungulates

Selenium Supplementation in Patients With Peripartum Cardiomyopathy: A Proof-of-Concept Trial

Selenium status of Omsk oblast

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