Selenium deficiency increases the pathology of an influenza virus infection

Beck, Melinda A.; Nelson, Heather K.; Shi, Qing; Dael, Peter Van; Schiffrin, Eduardo J.; Blum, Stéphanie; Barclay, Denis; Levander, Orville A.

doi:10.1096/fj.00-0721fje

Cited by 253 publications

(224 citation statements)

References 42 publications

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“…However, antibody titers to poliovirus were not affected by levels of Se intake, thus suggesting that plasma B cell production of IgG was not affected by Se supplementation. Consistent with this notion, rodent studies described in detail next involving influenza infection also showed no significant effect of increasing dietary Se on humoral responses (18). In a very small study involving 11 men, antibody titers against diphteria vaccine, but not against influenza A or B, were increased after reinoculation in high Sesupplemented (297 lg/day) versus low Se-supplemented (13 lg/day) individuals (95).…”

Section: B B Cell Function and Antibody Productionmentioning

confidence: 66%

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The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities

Huang

Rose

Hoffmann

2012

Antioxidants & Redox Signaling

710

496

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Dietary selenium (]Se), mainly through its incorporation into selenoproteins, plays an important role in inflammation and immunity. Adequate levels of Se are important for initiating immunity, but they are also involved in regulating excessive immune responses and chronic inflammation. Evidence has emerged regarding roles for individual selenoproteins in regulating inflammation and immunity, and this has provided important insight into mechanisms by which Se influences these processes. Se deficiency has long been recognized to negatively impact immune cells during activation, differentiation, and proliferation. This is related to increased oxidative stress, but additional functions such as protein folding and calcium flux may also be impaired in immune cells under Se deficient conditions. Supplementing diets with above-adequate levels of Se can also impinge on immune cell function, with some types of inflammation and immunity particularly affected and sexually dimorphic effects of Se levels in some cases. In this comprehensivearticle, the roles of Se and individual selenoproteins in regulating immune cell signaling and function are discussed. Particular emphasis is given to how Se and selenoproteins are linked to redox signaling, oxidative burst, calcium flux, and the subsequent effector functions of immune cells. Data obtained from cell culture and animal models are reviewed and compared with those involving human physiology and pathophysiology, including the effects of Se levels on inflammatory or immune-related diseases including anti-viral immunity, autoimmunity, sepsis, allergic asthma, and chronic inflammatory disorders. Finally, the benefits and potential adverse effects of intervention with Se supplementation for various inflammatory or immune disorders are discussed. Antioxid. Redox Signal. 16, 705-743.

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Section: B B Cell Function and Antibody Productionmentioning

confidence: 66%

“…Influenza viruses. Studies comparing Se-deficient to Se-sufficient mice infected with influenza A virus [Influenza A/Bangkok/1/79 (H3N2)] demonstrated the importance of adequate Se intake for viral clearance and recovery (18). Viral titers were similar between Se-deficient and Se-sufficient hosts.…”

Section: Linkages Between Se and Human Diseasementioning

confidence: 99%

The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities

Huang

Rose

Hoffmann

2012

Antioxidants & Redox Signaling

710

496

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“…Se-deficient mice exhibit increased pathology from viral infection, owing to an exaggerated pro-inflammatory immune response. 204,205 Se deficiency or deletion of GPx1 in mice also increases viral mutations and virulence. 206 Accordingly from these functions, it is expected that Se carries out beneficial effects on inflammatory conditions.…”

Section: Immune Defence and Inflammatory Disordersmentioning

confidence: 99%

Selenium biochemistry and its role for human health

Roman¹,

Jitaru²,

Barbante³

2014

Metallomics

652

451

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Despite its very low level in humans, selenium plays an important and unique role among the (semi)metal trace essential elements because it is the only one for which incorporation into proteins is genetically encoded, as the constitutive part of the 21st amino acid, selenocysteine. Twenty-five selenoproteins have been identified so far in the human proteome. The biological functions of some of them are still unknown, whereas for others there is evidence for a role in antioxidant defence, redox state regulation and a wide variety of specific metabolic pathways. In relation to these functions, the selenoproteins emerged in recent years as possible biomarkers of several diseases such as diabetes and several forms of cancer. Comprehension of the selenium biochemical pathways under normal physiological conditions is therefore an important requisite to elucidate its preventing/therapeutic effect for human diseases. This review summarizes the most recent findings on the biochemistry of active selenium species in humans, and addresses the latest evidence on the link between selenium intake, selenoproteins functionality and beneficial health effects. Primary emphasis is given to the interpretation of biochemical mechanisms rather than epidemiological/observational data. In this context, the review includes the following sections: (1) brief introduction; (2) general nutritional aspects of selenium; (3) global view of selenium metabolic routes; (4) detailed characterization of all human selenoproteins; (5) detailed discussion of the relation between selenoproteins and a variety of human diseases.

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“…That adequate selenium is required for protection against viral infection has been demonstrated by Beck (1997) and Beck and Levander (2000), who suggest that nutritional deprivation may be one of many factors that increase the susceptibility of individuals to influenza infection (Beck et al, 2001). There is insufficient data, particularly in human subjects, to estimate an optimal dietary intake or an optimal plasma selenium concentration for protection against viral infection.…”

Section: Blood Selenium Concentrations Above Which Keshan Disease Ismentioning

confidence: 99%

Assessment of requirements for selenium and adequacy of selenium status: a review

2004

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Objective: The intent of this review is to evaluate the scientific evidence for the assessment of adequacy of selenium status and of the requirements for selenium. From this evidence, attempts have been made to define levels of plasma selenium and dietary selenium intake, which could be used for the assessment of deficiency or adequacy of selenium status. Method: The first section briefly reviews the methods for assessment of selenium status. The second section outlines the requirements for selenium based on a number of criteria, and how these have been translated into recommended intakes of selenium. In the final section, levels of plasma selenium and dietary intake based on different criteria of adequacy have been proposed. Results and conclusion: The minimum requirement for selenium is that which prevents the deficiency disease, Keshan disease. The recommended intakes of selenium have been calculated from the requirement for optimum plasma glutathione peroxidase (GPx) activity that must, because of the hierarchy of selenoproteins, also take account of the amounts needed for normal levels of other biologically necessary selenium compounds. Whether optimal health depends upon maximization of GPx or other selenoproteins, however, has yet to be resolved, and the consequences of less-than-maximal GPx activities or mRNA levels need investigation. Intakes, higher than recommended intakes, and plasma selenium concentrations that might be protective for cancer or result in other additional health benefits have been proposed. There is an urgent need for more large-scale trials to assess any such beneficial effects and to provide further data on which to base more reliable estimates for intakes and plasma selenium levels that are protective.

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Selenium deficiency increases the pathology of an influenza virus infection

Cited by 253 publications

References 42 publications

The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities

The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities

Selenium biochemistry and its role for human health

Assessment of requirements for selenium and adequacy of selenium status: a review

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