Selenium Deficiency Induces Inflammatory Response and Decreased Antimicrobial Peptide Expression in Chicken Jejunum Through Oxidative Stress

He, Yujiao; Peng, Lin; Xiaochun, Zhao; Fan, Xue; Tang, Xinyu; Shi, Guangliang; Li, Shu

doi:10.1007/s12011-022-03442-w

Cited by 5 publications

(2 citation statements)

References 53 publications

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“…Other structural studies using transmission electron microscopy revealed damages in the jejunum epithelial microvilli of broilers, mitochondrial swelling and vacuolation due to the lack of selenium. In the same study at the molecular level, intestinal inflammatory factors (NF-κB P65, IKKα, IKKβ, IL-1β, IL-6, IFN-γ, and TNF-α) were upregulated, while anti-inflammatory IL-10 was significantly downregulated [ 126 ]. Only a few studies focused on the epithelial barrier integrity following enteric infection; in a paper on this issue, the mice fed with a selenium-supplemented or a selenium-deficient diet were infected with C. rodentium strain ICC 169 (nalidixic acid resistant), and the analysis of ILC3 and Th17 cells was performed.…”

Section: Role Of Selenium In Inflammation and Immunitymentioning

confidence: 99%

Selenium-Containing Agents Acting on Cancer—A New Hope?

et al. 2022

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Selenium-containing agents are more and more considered as an innovative potential treatment option for cancer. Light is shed not only on the considerable advancements made in understanding the complex biology and chemistry related to selenium-containing small molecules but also on Se-nanoparticles. Numerous Se-containing agents have been widely investigated in recent years in cancer therapy in relation to tumour development and dissemination, drug delivery, multidrug resistance (MDR) and immune system-related (anti)cancer effects. Despite numerous efforts, Se-agents apart from selenocysteine and selenomethionine have not yet reached clinical trials for cancer therapy. The purpose of this review is to provide a concise critical overview of the current state of the art in the development of highly potent target-specific Se-containing agents.

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Section: Role Of Selenium In Inflammation and Immunitymentioning

confidence: 99%

Selenium-Containing Agents Acting on Cancer—A New Hope?

et al. 2022

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“…However, chronic selenium de ciency is associated with stunted growth, diarrhea, and malnutrition [22]. He, Yujiao et al found that selenium de ciency can reduce the level of antioxidant selenium protein, induce oxidative stress, reduce intestinal antimicrobial peptides, and lead to jejunal in ammatory damage and intestinal barrier destruction [23]. Zheng, Yingying, et al demonstrated that selenium de ciency caused endoplasmic reticulum stress in porcine small intestine, increased apoptosis of porcine small intestine and IPEC-J2 cells, and thus caused damage to porcine small intestine tissue [24].…”

Section: Introductionmentioning

confidence: 99%

Lactobacillus_reuteri improves intestinal damage caused by selenium deficiency in mice by altering intestinal flora

Wang,

Li,

et al. 2024

Preprint

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Background Selenium is an indispensable micronutrient in the physiological activities of humans and animals. Due to the different distribution of selenium worldwide, people and animals in some areas have been in a state of selenium deficiency for a long time. Studies have found that chronic selenium deficiency can cause intestinal damage, closely related to changes in intestinal microbes. However, its regulation mechanism by intestinal microbes has yet to be explored. Results In this study, we found that chronic selenium deficiency can cause changes in the microecology of intestinal flora and intestinal damage in mice. After supplementation of probiotic Lactobacillus_reuteri, the intestinal flora structure of selenium-deficient mice was adjusted. The intestinal damage was improved. Histological analysis showed that the LSeJ group's intestinal structure was changed after ingestion of Lactobacillus_reuteri. Although the intestinal villi in LSeJ group were shorter or even broken, the intestinal crypts in LSeJ group were more numerous, the muscular layer was thicker, and the intestinal villi arrangement was denser than that in LSeN group. We examined mRNA and protein expression levels of small intestine genes related to inflammation, autophagy, endoplasmic reticulum stress, apoptosis, tight junction, and smooth muscle contraction. The results showed that after treatment with Lactobacillus_reuteri, the expression level of inflammatory factors in selenium-deficient mice decreased. The degree of autophagy was reduced, endoplasmic reticulum stress was reduced, apoptosis level was decreased, tight junctions were restored, and smooth muscle contraction was improved. It suggests that changes in the relative abundance of intestinal flora across species are associated with inflammation of intestinal tissue cells, autophagy, endoplasmic reticulum stress, apoptosis, tight junctions, and abnormal smooth muscle contraction. Conclusions Lactobacillus_reuteri can improve intestinal tissue inflammation, autophagy, endoplasmic reticulum stress, apoptosis, tight junction, and abnormal smooth muscle contraction caused by selenium deficiency. Intestinal flora plays an important role in the mechanism of chronic intestinal injury caused by selenium deficiency. It suggests potential intervention strategies based on intestinal injury caused by selenium deficiency.

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