Selenium deficiency is associated with insulin resistance in patients with hepatitis C virus–related chronic liver disease

“…The instrument was valid for measurement of the habitual intake of antioxidant vitamins (A, E), in addition to the minerals selenium (r = 0.81) and zinc (r = 0.54). Zinc and selenium deficiency has been linked to the severity of liver disease, insulin resistance, and the decrease of sustained virological response in patients with HCV infection [12][13] . The validity of the FFQ for the measurement of other assessed micronutrients was adequate.…”

Section: Tablementioning

confidence: 99%

Relative validity of a food frequency questionnaire in patients coinfected with hepatitis C virus and human immunodeficiency virus

Zanolla

Buss

Kliemann

et al. 2017

Rev. Soc. Bras. Med. Trop.

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Introduction: Validation of food frequency questionnaires (FFQs) is recommended for accurate measurement of habitual food consumption. We assessed the relative validity of a FFQ in patients coinfected with hepatitis C virus and human immunodeficiency virus. Methods: Each patient responded to a FFQ and three 24-hour food recalls. Pearson's correlation and weighted Kappa index analyses were performed to identify the FFQ relative validity and concordance. Results: De-attenuated correlation coefficients ranged from 0.35 (vitamin B1) to 0.81 (selenium). The concordance index ranged from 0.07 (vitamin C) to 0.51 (calcium). Conclusions:The FFQ showed satisfactory relative validity for most nutrients.

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“…It was recently shown that selenium deficiency was also related to the severity of hepatic fibrosis in patients with hepatitis C-related chronic liver disease being one of the factors contributing to insulin resistance in these patients. 61 Manganese Total body manganese stores are increased in patients with liver disease, 62,63 which may lead to selective manganese accumulation in several areas of the brain. [64][65][66] Manganese deposition in basal ganglia structures of the brain has been proposed as the cause of T1-weighted magnetic resonance signal hyperintensities 65 and cirrhosisrelated Parkinsonism.…”

Section: Seleniummentioning

confidence: 99%