Selenium Doped Graphene Quantum Dots as an Ultrasensitive Redox Fluorescent Switch

Yang, Siwei; Sun, Jing; He, Peng; Deng, Xinxia; Wang, Zhongyang; Hu, Chenyao; Ding, Guqiao; Xie, Xiaoming

doi:10.1021/acs.chemmater.5b00112

Cited by 204 publications

(117 citation statements)

References 74 publications

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“…Solvent optimization ( Table 1, entries [1][2][3][4][5][6][7][8][9] showed that toluene was the ideal solvent, while other reaction media gave significantly lower yields. Solvent optimization ( Table 1, entries [1][2][3][4][5][6][7][8][9] showed that toluene was the ideal solvent, while other reaction media gave significantly lower yields.…”

Section: Optimization Studiesmentioning

confidence: 99%

Ruthenium(II)‐Catalyzed C−H Chalcogenation of Anilides

Weng

Rogge

et al. 2017

Adv Synth Catal

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Ruthenium-catalyzed CÀH chalcogenations of anilides with readily available diselenides and disulfides have been achieved. Our strategy features ample substrate scope, affording the mono-ortho selenylated and thiolated anilides with complete site selectivity control and high catalytic efficacy. Detailed mechanistic studies provide strong support for a facile base-assisted internal electrophilic substitution (BIES) metalation event.

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Section: Optimization Studiesmentioning

confidence: 99%

Ruthenium(II)‐Catalyzed C−H Chalcogenation of Anilides

Weng

Rogge

et al. 2017

Adv Synth Catal

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“…In this regard, post-modification is an alternative approach, in which GQDs can be modified by post-processing. 58,[60][61][62][63][64][65][66][67][68] Post-modification allows one to design GQDs with rationally improved properties. Polymer passivation is an often-adopted method to improve the quantum yield of GQDs.…”

Section: Post-modification Of Gqdsmentioning

confidence: 99%

Properties and Synthesis Strategies of Graphene Quantum Dots

Zhang¹,

Lu²

2017

Frontiers in Nanobiomedical Research

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Quantum dots (QDs) are usually referred to as semiconductor nanoparticles with their sizes in the quantum-confined regime, in which the excitons are confined in all the three spatial dimensions. Typical QDs are inorganic semiconductor nanocrystals from the group II-VI elements in the periodic table. However, the applications of these QDs are limited by their internal disadvantages, including intrinsic toxicity (e.g. in the case of widely studied CdSe QDs) and problems caused by the colloidal stability. Therefore, developing new QDs and relevant nanomaterials is necessary. Consequently, graphene quantum dots (GQDs), a class of zero-dimensional (0D) graphitic nanomaterials, have attracted increasing attention recently. Compared with semiconductor QDs, GQDs are superior in terms of low cytotoxicity, high dispersity in water and some polarity organic solvents, resistance to photobleaching and biocompatibility. In addition, the properties of GQDs are easier to be tuned through surface chemistry, indicating that researchers can design GQDs with various functionalities for different applications.

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“…Moreover, cancer cells can generate abundant H 2 O 2 compared to normal cells. Through Fenton reaction, H 2 O 2 can be activated by Fe 3+ /Fe 2+ to produce toxic hydroxyl radicals (•OH) (Equations and ), which can damage biological molecules to induce cell apoptosis . Furthermore, more •OH can be generated by recycling of Fe 2+ with irradiation of UV through Equation

{normalH}_{2} {normalO}_{2} + {Fe}^{2 +} \to {Fe}^{3 +} + • OH + {OH}^{-}

{Fe}^{3 +} + {normalH}_{2} {normalO}_{2} \to {Fe}^{2 +} + {HO}_{2}^{-} + {normalH}^{+}

Fe {(normalOH)}^{2 +} + h ν \to {Fe}^{2 +} + • OH

…”

Section: Introductionmentioning

confidence: 99%

Glutathione Mediated Size‐Tunable UCNPs‐Pt(IV)‐ZnFe₂O₄ Nanocomposite for Multiple Bioimaging Guided Synergetic Therapy

Dai

Yang

et al. 2018

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Here a multifunctional nanoplatform (upconversion nanoparticles (UCNPs)-platinum(IV) (Pt(IV))-ZnFe O , denoted as UCPZ) is designed for collaborative cancer treatment, including photodynamic therapy (PDT), chemotherapy, and Fenton reaction. In the system, the UCNPs triggered by near-infrared light can convert low energy photons to high energy ones, which act as the UV-vis source to simultaneously mediate the PDT effect and Fenton's reaction of ZnFe O nanoparticles. Meanwhile, the Pt(IV) prodrugs can be reduced to high virulent Pt(II) by glutathione in the cancer cells, which can bond to DNA and inhibit the copy of DNA. The synergistic therapeutic effect is verified in vitro and in vivo results. The cleavage of Pt(IV) from UCNPs during the reduction process can shift the larger UCPZ nanoparticles (NPs) to the smaller ones, which promotes the enhanced permeability and retention (EPR) and deep tumor penetration. In addition, due to the inherent upconversion luminescence (UCL) and the doped Yb and Fe in UCPZ, this system can serve as a multimodality bioimaging contrast agent, covering UCL, X-ray computed tomography, magnetic resonance imaging, and photoacoustic. A smart all-in-one imaging-guided diagnosis and treatment system is realized, which should have a potential value in the treatment of tumor.

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Selenium Doped Graphene Quantum Dots as an Ultrasensitive Redox Fluorescent Switch

Cited by 204 publications

References 74 publications

Ruthenium(II)‐Catalyzed C−H Chalcogenation of Anilides

Ruthenium(II)‐Catalyzed C−H Chalcogenation of Anilides

Properties and Synthesis Strategies of Graphene Quantum Dots

Glutathione Mediated Size‐Tunable UCNPs‐Pt(IV)‐ZnFe₂O₄ Nanocomposite for Multiple Bioimaging Guided Synergetic Therapy

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Selenium Doped Graphene Quantum Dots as an Ultrasensitive Redox Fluorescent Switch

Cited by 204 publications

References 74 publications

Ruthenium(II)‐Catalyzed C−H Chalcogenation of Anilides

Ruthenium(II)‐Catalyzed C−H Chalcogenation of Anilides

Properties and Synthesis Strategies of Graphene Quantum Dots

Glutathione Mediated Size‐Tunable UCNPs‐Pt(IV)‐ZnFe2O4 Nanocomposite for Multiple Bioimaging Guided Synergetic Therapy

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Glutathione Mediated Size‐Tunable UCNPs‐Pt(IV)‐ZnFe₂O₄ Nanocomposite for Multiple Bioimaging Guided Synergetic Therapy