Selenium exerts protective effects on inflammatory cardiovascular damage: molecular aspects via SIRT1/p53 and Cyt-c/Cas-3 pathways

İlhan, İlter; Aşçı, Halil; Tepebaşı, Muhammet Yusuf; İMECİ, Orhan Berk; Sevük, Mehmet Abdulkadir; Temel, Esra Nurlu; Özmen, Özlem

doi:10.1007/s11033-022-08192-5

Cited by 10 publications

(3 citation statements)

References 48 publications

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“…Güneş et al investigated the cardioprotective effects of SEL against cyclophosphamide-induced cardiotoxic effects in rats, they found that the activities of these enzyme markers decreased significantly in the SEL treated group (15). In recent studies, the antiinflammatory activity of selenium with similar markers is in parallel with our study (40,41). Considering these similar results in this study, SEL may have an antiinflammatory effect against the damage caused by various agents and the inflammation caused by this damage.…”

Section: Discussionsupporting

confidence: 86%

Akri̇lami̇de Maruz Kalan Siçanlarin Kalp Dokusu Üzeri̇nde Selenyumun Koruyucu Rolü

KARAKUYU

Aşçı

Savran

et al. 2023

SDÜ Tıp Fakültesi Dergisi

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Objective: Acrylamide (ACR) is a harmful organic reactive compound widely used in different industrial fields. Selenium (SEL) is a trace element that takes part in some chemical and enzymatic reactions in both animals and human organisms and can cause some disorders in many systems such as the cardiovascular system in case of deficiency. The aim of this study is to investigate whether SEL has a protective effect on cardiac tissue in experimentally induced ACR toxicity in rats. Material and Methods: A total of 28 rats were randomly and equally divided into four groups: Control, SEL, ACR, SEL + ACR. At the end of the study, cardiac markers such as creatine kinase MB (CKMB), lactate dehydrogenase (LDH) and ischemia-modified albumin (IMA) from blood samples were measured. Oxidative stress markers such as total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) in heart tissue were analyzed. In addition, inducible nitric oxide synthase iNOS activities were determined in heart sections using immunohistochemical methods. Results: The ACR + SEL group showed a significant decrease in TOS, OSI, CKMB, LDH, IMA levels and significant increase in TAS level compared to the ACR group. In histopathological and immunohistochemical evaluation of the heart sections; Disorganization in cardiac muscle fibers, increased connective tissue between muscle fibers and irregular eosinophilia in muscle fibers were detected in ACR group. A decrease in histopathological findings was observed in the SEL treated group compared to the ACR group. iNOS immunoreactivities; Moderate marking was observed in the ACR group sections, while poor marking was observed in the treatment group. Conclusion: We determined that ACR caused damage to the heart tissue of rats through various metabolic pathways and that these damages were reversed in the groups given the SEL.

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Section: Discussionsupporting

confidence: 86%

Akri̇lami̇de Maruz Kalan Siçanlarin Kalp Dokusu Üzeri̇nde Selenyumun Koruyucu Rolü

KARAKUYU

Aşçı

Savran

et al. 2023

SDÜ Tıp Fakültesi Dergisi

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“…Selenium is an integral component of selenoproteins, such as glutathione peroxidases, and confers protection against oxidative stress-induced damage ( 22 , 28 , 30 , 31 – 33 ). Moreover, particular signaling pathways and their interaction with microRNAs, as well as autophagy processes, contribute to the antioxidative effects of these proteins ( 34 , 35 ). Deficiencies in micronutrients can profoundly affect mitochondrial energy production, endothelial function regulation, skeletal muscle protection, and thyroid metabolism ( 36 – 38 ).…”

Section: Discussionmentioning

confidence: 99%

The cardiomyopathy of cystic fibrosis: a modern form of Keshan disease

Segovia-Cubero,

Ruiz-Bautista,

Maiz-Carro

et al. 2024

Front. Cardiovasc. Med.

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IntroductionWe conducted a study to determine the prevalence of structural heart disease in patients with CF, the characteristics of a cardiomyopathy not previously described in this population, and its possible relationship with nutritional deficiencies in CF.MethodsWe studied 3 CMP CF patients referred for heart-lung transplantation and a prospective series of 120 adult CF patients. All patients underwent a clinical examination, blood tests including levels of vitamins and trace elements, and echocardiography with evaluation of myocardial strain. Cardiac magnetic resonance imaging (CMR) was performed in patients with CMP and in a control group. Histopathological study was performed on hearts obtained in transplant or necropsy.ResultsWe found a prevalence of 10% (CI 4.6%–15.4%) of left ventricular (LV) dysfunction in the prospective cohort. Myocardial strain parameters were already altered in CF patients with otherwise normal hearts. Histopathological examination of 4 hearts from CF CMP patients showed a unique histological pattern of multifocal myocardial fibrosis similar to Keshan disease. Four of the five CF CMP patients undergoing CMR showed late gadolinium uptake, with a characteristic patchy pattern in 3 cases (p < 0.001 vs. CF controls). Selenium deficiency (Se < 60 µg/L) was associated with more severe LV dysfunction, higher prevalence of CF CMP, higher NTproBNP levels, and more severe pulmonary and digestive involvement.Conclusion10% of adults with CF showed significant cardiac involvement, with histological and imaging features resembling Keshan disease. Selenium deficiency was associated with the presence and severity of LV dysfunction in these patients.

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“…There is a history of therapeutic power in the control the OS deregulation and in the control of the inflammatory process [81]. However, the equilibrium threshold in the concentration in this trace element is very important, because an excess could lead to selenosis and contribute to inflammation in various disorders [83][84][85].…”

Section: Discussionmentioning

confidence: 99%

Randomized Clinical Trial of Antioxidant Therapy Patients with Septic Shock and Organ Dysfunction in the ICU: SOFA Score Reduction by Improvement of the Enzymatic and Non-Enzymatic Antioxidant System

Aisa-Álvarez,

Pérez-Torres,

Guarner-Lans

et al. 2023

Cells

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Background and aim: Here, we assess the effect of adjuvant antioxidant therapies in septic shock patients with organ dysfunction and their effect on the enzymatic and non-enzymatic antioxidant systems. Methods: Randomized clinical trial run between 2018 and 2022. One hundred and thirty-one patients with septic shock were included in five groups with 25, 27, 24, 26 and 29 patients each. Group 1 received vitamin C (Vit C), Group 2 vitamin E (Vit E), Group 3 n-acetylcysteine (NAC), Group 4 melatonin (MT) and group 5 no treatment. All antioxidants were administered orally or through a nasogastric tube for 5 days as an adjuvant to standard therapy. Results: All patients had multiple organ failure (MOF) and low Vit C levels. Vit C therapy decreased CRP, PCT and NO3−/NO2– but increased Vit C levels. The SOFA score decreased with MT in 75%, Vit C 63% and NAC 50% vs. controls 33% (p = 0.0001, p = 0.03 and p = 0.001 respectively). MT diminished lipid peroxidation (LPO) (p = 0.01) and improved total antioxidant capacity (TAC) (p = 0.04). Vit E increased thiol levels (p = 0.02) and tended to decrease LPO (p = 0.06). Selenium levels were decreased in the control group (p = 0.04). Conclusions: Antioxidants used as an adjuvant therapy in the standard treatment of septic shock decrease MOF and oxidative stress markers. They increase the TAC and thiols, and maintain selenium levels.

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Selenium exerts protective effects on inflammatory cardiovascular damage: molecular aspects via SIRT1/p53 and Cyt-c/Cas-3 pathways

Cited by 10 publications

References 48 publications

Akri̇lami̇de Maruz Kalan Siçanlarin Kalp Dokusu Üzeri̇nde Selenyumun Koruyucu Rolü

Akri̇lami̇de Maruz Kalan Siçanlarin Kalp Dokusu Üzeri̇nde Selenyumun Koruyucu Rolü

The cardiomyopathy of cystic fibrosis: a modern form of Keshan disease

Randomized Clinical Trial of Antioxidant Therapy Patients with Septic Shock and Organ Dysfunction in the ICU: SOFA Score Reduction by Improvement of the Enzymatic and Non-Enzymatic Antioxidant System

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