Selenium, Glutathione Peroxidase and Superoxide Dismutase in Maltese Asthmatic Patients: Effect of Glucocorticoid Administration

Fenech, Anthony G.; Ellul-Micallef, Roger

doi:10.1006/pupt.1998.0122

Cited by 38 publications

(31 citation statements)

References 14 publications

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“…-into oxygen and hydroperoxide, which is then acted upon by GSHPx to form water. SOD activity has been reported to be increased [46], decreased [36,[47][48][49][50][51] or unchanged [28,44,45,52,53] in asthmatics compared with controls. Zn, a cofactor of SOD, has also been reported to be decreased [28,54] or unchanged [55].…”

Section: Evidence Relating Lipid Peroxidation and Asthmamentioning

confidence: 99%

“…Zn, a cofactor of SOD, has also been reported to be decreased [28,54] or unchanged [55]. Similarly, GSHPx activity has been reported to be decreased [36,44,53,[56][57][58][59][60][61] or unchanged [28, 47-49, 51, 52, 57, 60, 62] in asthmatics, with Se, a cofactor of GSHPx, being decreased [28,57,[60][61][62] or unchanged [49,57,62]. Catalase, another antioxidant enzyme, has also been reported to have low activity [36,52] or unchanged [44,47,48,51].…”

Section: Evidence Relating Lipid Peroxidation and Asthmamentioning

confidence: 99%

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Biomarkers of lipid peroxidation, airway inflammation and asthma

Wood¹,

Gibson²,

Garg³

2003

Eur Respir J

272

201

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Oxidative stress, specifically lipid peroxidation, is believed to contribute to the pathophysiology of asthma. This review highlights the pathways through which reactive oxygen species (ROS) may lead to lipid peroxidation. The potential of both the innate and acquired immune systems to activate inflammatory cells and release ROS that may overwhelm the host antioxidant defences and cause lipid peroxidation, accompanied by detrimental pathophysiological effects, are discussed.Despite the evidence demonstrating the importance of lipid peroxidation, systematic characterisation of oxidative stress and antioxidant defences has not been undertaken, largely due to the lack of appropriate biomarkers. This review discusses the emergence of isoprostanes (specifically 8-iso-prostaglandin F 2a ) as reliable, in vivo markers of lipid peroxidation, which provides an appropriate tool for studying oxidative stress. Furthermore, the development of techniques to study induced sputum and breath condensate, derived directly from the airway surface, enables the site of oxidative damage to be closely assessed.Evidence suggests that dietary changes that have occurred over recent years have increased susceptibility to lipid peroxidation, due to reduced antioxidant defences. To date, the limited number of long-term (w1 week) supplementation trials have been promising. However, the development of techniques to study isoprostanes in airwaylining fluid pave the way for further studies investigating the potential for antioxidant supplements to be used as routine therapy in asthma.

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Section: Evidence Relating Lipid Peroxidation and Asthmamentioning

confidence: 99%

Section: Evidence Relating Lipid Peroxidation and Asthmamentioning

confidence: 99%

Biomarkers of lipid peroxidation, airway inflammation and asthma

Wood¹,

Gibson²,

Garg³

2003

Eur Respir J

272

201

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“…23 Fenech et al reported that in moderate and severe asthma attacks, patients' plasma SOD levels are lower than in normal people, and routine use of steroids in patients with asthma affects SOD levels. 24 Fitzpatrick et al observed that children who had severe asthma attacks tended to have high levels of oxidative stress in the epithelial lining fluid (ELF). In turn, this would increase the conversion of glutathione (GSH) and glutathione disulfide (GSSG) to glutathione redox.…”

Section: Discussionmentioning

confidence: 99%

Superoxide dismutase levels and peak expiratory flow in asthmatic children

Kurniasih

Julia

Setyati

2016

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“…5-7, 21, 32 Chronic disease impairs other systems, such as the nervous system, vision, mechanisms related to blood pressure, and also may affect the survival and maturation of RBCs, which may promote increased RBC production, contributing to an elevated RDW level. 6,11,21,133,134 The presence of certain chronic diseases, such as cardiovascular disease, diabetes, and pulmonary disease, may increase the risk to fall in elderly subjects. 131,132 The primary purpose of the study was to determine the cross-sectional association between RDW and the number of falls among older adults living in a skilled nursing facility.…”

Section: Background and Study Goalmentioning

confidence: 99%