Selenium homeostasis in the central nervous system of the rat

Pullen, R. G. L.; Schofield, M.; Markham, Anthony; Lough, John; Menton, K.

doi:10.1016/0024-3205(96)00206-8

Life Sciences

1996

DOI: 10.1016/0024-3205(96)00206-8

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Selenium homeostasis in the central nervous system of the rat

R. G. L. Pullen

M. Schofield

Anthony Markham

et al.

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Cited by 7 publications

(1 citation statement)

References 26 publications

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“…The application of a radiotracer offers diverse insights in trace element metabolism but has also specific requirements and limitations. Former investigations with the application of 75 Se (Trapp and Millam 1975; Pullen et al. 1995, 1996) and own recent studies about the selenium uptake and homeostasis in the CNS (Hoppe et al.…”

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confidence: 99%

The brain selenoproteome: priorities in the hierarchy and different levels of selenium homeostasis in the brain of selenium‐deficient rats

Kühbacher¹,

Bartel²,

Hoppe³

et al. 2009

Journal of Neurochemistry

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The application of radionuclides for the localization of essential trace elements in vivo and the characterization of their binding proteins is a story of intermittently made improvements of the techniques used for their detection. In this study we present the use of neutron activation analysis and different autoradiographic imaging methods including real‐time digital autoradiography to reveal new insights in the hierarchy of selenium homeostasis. Selenoproteins containing the essential trace element selenium play important roles in the CNS. Although the CNS does not show the highest selenium concentration in the case of selenium‐sufficient supply in comparison with other organs, it shows a high priority for selenium uptake and retention in the case of dietary selenium deficiency. To characterize the hierarchy of selenium supply in the brain, in vivo radiotracer labeling with 75Se in rats with different selenium status was combined with autoradiographic detection of 75Se in brain tissue sections and 75Se‐labeled selenoproteins after protein separation by two‐dimensional gel electrophoresis. This study demonstrates significant differences in the uptake of 75Se into the brain of rats with different selenium status. A brain region‐specific uptake pattern of the radiotracer 75Se in selenium‐deficient rats could be revealed and the CSF was identified as a key part of the brain selenium homeostasis.

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confidence: 99%

The brain selenoproteome: priorities in the hierarchy and different levels of selenium homeostasis in the brain of selenium‐deficient rats

Kühbacher¹,

Bartel²,

Hoppe³

et al. 2009

Journal of Neurochemistry

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Increase in Dopamine Metabolites in Murine Striatum After Oral Exposure to Inorganic But Not Organic Form of Selenium

Tsunoda

Johnson

Sharma

2000

Archives of Environmental Contamination and Toxicology

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Selenium (Se) is an essential as well as a toxic trace element. Se intoxication has been reported in both livestock and humans. The central nervous system is sensitive to Se poisoning; exposure to Se causes blind staggers in cattle, poliomyelomalacia in pigs, and nervous system disorders in humans. Differences in neurotoxicity between inorganic and organic Se have been demonstrated. In this study, groups of five male BALB/c mice each were administered sodium selenite or selenomethionine in drinking water ad libitum at 0, 1, 3, and 9 ppm as Se for 14 days. At the end of Se exposure, their brains were removed and dissected into different regions. The concentration of norepinephrine (NE), dopamine (DA), dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), serotonin (5-HT), and 5-hydroxyindolacetic acid (5-HIAA) were determined in each brain region. Food and water consumption and body weight gain were significantly decreased in the group treated with the highest concentration of sodium selenite. In mice administered sodium selenite at 3 and 9 ppm, DOPAC was significantly higher in the striatum than in the control group. The striatal HVA was also increased in the group treated with 3 ppm Se; the DA showed a similar pattern, but the increase was not statistically significant. No alterations of NE, 5-HT, or 5-HIAA levels were detected in any brain region of mice treated with sodium selenite. No significant differences in any parameter among the groups treated with selenomethionine were observed indicating that inorganic Se was more neurotoxic than organic Se via drinking water. The alterations of DA metabolites by inorganic Se in DA-rich striatum suggested a Se-specific increased neural activity of dopaminergic pathways. Results may be useful in further elucidation of neurotoxicity of Se and in establishing a safe level of intake for this element.

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Effects of low-level organic selenium on lead-induced alterations in neural cell adhesion molecules

Mao

Xiao

et al. 2013

Brain Research

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Selenium homeostasis in the central nervous system of the rat

Cited by 7 publications

References 26 publications

The brain selenoproteome: priorities in the hierarchy and different levels of selenium homeostasis in the brain of selenium‐deficient rats

The brain selenoproteome: priorities in the hierarchy and different levels of selenium homeostasis in the brain of selenium‐deficient rats

Increase in Dopamine Metabolites in Murine Striatum After Oral Exposure to Inorganic But Not Organic Form of Selenium

Effects of low-level organic selenium on lead-induced alterations in neural cell adhesion molecules

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