Selenium-<i>N</i>-heterocyclic carbene (Se-NHC) complexes with higher aromaticity inhibit microbes: synthesis, structure, and biological potential

Kamal, Ali; Iqbal, Muhammad Adnan; Bhatti, Haq Nawaz; Ghaffar, Abdul

doi:10.1080/00958972.2022.2101921

Journal of Coordination Chemistry

2022

DOI: 10.1080/00958972.2022.2101921

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Selenium-N-heterocyclic carbene (Se-NHC) complexes with higher aromaticity inhibit microbes: synthesis, structure, and biological potential

Ali Kamal

Muhammad Adnan Iqbal

Haq Nawaz Bhatti

et al.

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Cited by 11 publications

References 51 publications

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The first evaluation of the in vitro effects of silver(I)-N-heterocyclic carbene complexes on Encephalitozoon intestinalis and Leishmania major promastigotes

Ataş,

Akın-Polat,

Gülpınar

et al. 2024

J Biol Inorg Chem

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Encephalitozoon intestinalis is an opportunistic microsporidian parasite that primarily infects immunocompromised individuals, such as those with HIV/AIDS or undergoing organ transplantation. Leishmaniasis is responsible for parasitic infections, particularly in developing countries. The disease has not been effectively controlled due to the lack of an effective vaccine and affordable treatment options. Current treatment options for E. intestinalis infection and leishmaniasis are limited and often associated with adverse side effects. There is no previous study in the literature on the antimicrosporidial activities of Ag(I)-N-heterocyclic carbene compounds. In this study, the in vitro antimicrosporidial activities of previously synthesized Ag(I)-N-heterocyclic carbene complexes were evaluated using E. intestinalis spores cultured in human renal epithelial cell lines (HEK-293). Inhibition of microsporidian replication was determined by spore counting. In addition, the effects of the compounds on Leishmania major promastigotes were assessed by measuring metabolic activity or cell viability using a tetrazolium reaction. Statistical analysis was performed to determine significant differences between treated and control groups. Our results showed that the growth of E. intestinalis and L. major promastigotes was inhibited by the tested compounds in a concentration-dependent manner. A significant decrease in parasite viability was observed at the highest concentrations. These results suggest that the compounds have potential anti-microsporidial and anti-leishmanial activity. Further research is required to elucidate the underlying mechanisms of action and to evaluate the efficacy of the compounds in animal models or clinical trials. Graphical abstract

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The first evaluation of the in vitro effects of silver(I)-N-heterocyclic carbene complexes on Encephalitozoon intestinalis and Leishmania major promastigotes

Ataş,

Akın-Polat,

Gülpınar

et al. 2024

J Biol Inorg Chem

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Biological potential of vinyl/allyl substituted imidazole-based N-heterocyclic carbene adducts: synthesis, spectral and X-ray crystallographic structural characteristics

Kamal,

Ibrahim,

Al-Rawi

et al. 2023

Chem. Pap.

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N-heterocyclic carbene based Bi-nuclear organoselenium compounds impart a mild biocidal potential compared to their ligands: Synthesis, characterization, computational studies

Hassan,

Iqbal,

Bhatti

et al. 2023

Computational Biology and Chemistry

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Selenium-N-heterocyclic carbene (Se-NHC) complexes with higher aromaticity inhibit microbes: synthesis, structure, and biological potential

Cited by 11 publications

References 51 publications

The first evaluation of the in vitro effects of silver(I)-N-heterocyclic carbene complexes on Encephalitozoon intestinalis and Leishmania major promastigotes

The first evaluation of the in vitro effects of silver(I)-N-heterocyclic carbene complexes on Encephalitozoon intestinalis and Leishmania major promastigotes

Biological potential of vinyl/allyl substituted imidazole-based N-heterocyclic carbene adducts: synthesis, spectral and X-ray crystallographic structural characteristics

N-heterocyclic carbene based Bi-nuclear organoselenium compounds impart a mild biocidal potential compared to their ligands: Synthesis, characterization, computational studies

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