Selenium in food and the human body: A review

Navarro-Alarcón, Miguel; Cabrera–Vique, Carmen

doi:10.1016/j.scitotenv.2008.06.024

Cited by 737 publications

(510 citation statements)

References 155 publications

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“…Estimation of Se intake from nutritional databases also involves a limitation. Se content of foods may differ depending on geographical region, season of cultivation and also food processing (43) . In the USA, for CRP, C-reactive protein; NHANES, National Health and Nutrition Examination Survey; ATE, a-tocopherol equivalents; RE, retinol equivalents.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant intake from diet and supplements and elevated serum C-reactive protein and plasma homocysteine concentrations in US adults: a cross-sectional study

Floegel

Chung

Ruesten

et al. 2011

Public Health Nutr.

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Objective: To investigate the association of antioxidant intakes from diet and supplements with elevated blood C-reactive protein (CRP) and homocysteine (Hcy) concentrations. Design: A cross-sectional study. The main exposures were vitamins C and E, carotene, flavonoid and Se intakes from diet and supplements. Elevated blood CRP and Hcy concentrations were the outcome measures. Setting: The US population and its subgroups. Subjects: We included 8335 US adults aged $19 years from the National Health and Nutrition Examination Survey 1999-2002. Results: In this US population, the mean serum CRP concentration was 4?14 (95 % CI 3?91, 4?37) mg/l. Intakes of vitamins C and E and carotene were inversely associated with the probability of having serum CRP concentrations .3 mg/l in multivariate logistic regression models. Flavonoid and Se intakes were not associated with the odds of elevated serum CRP concentrations. The mean plasma Hcy concentration was 8?61 (95 % CI 8?48, 8?74) mmol/l. Intakes of vitamins C, E, carotenes and Se were inversely associated with the odds of plasma Hcy concentrations .13 mmol/l after adjusting for covariates. Flavonoid intake was not associated with the chance of elevated plasma Hcy concentrations. Conclusions: These results suggest that high antioxidant intake is associated with lower blood concentrations of CRP and Hcy. These inverse associations may be among the potential mechanisms for the beneficial effect of antioxidant intake on CVD risk mediators in observational studies.

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Section: Discussionmentioning

confidence: 99%

Antioxidant intake from diet and supplements and elevated serum C-reactive protein and plasma homocysteine concentrations in US adults: a cross-sectional study

Floegel

Chung

Ruesten

et al. 2011

Public Health Nutr.

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“…6,8 The level of Se in crops is related to that in the soil; the bioavailability is regulated by physicochemical conditions of the soils such as the pH, redox conditions, salinity, organic matter, etc. 9 Crops are an important source of Se taking into account their consumption on a global scale. Nevertheless, Se in crops is generally of low abundance because such plants do not require Se for growth, and hence do not accumulate it under normal physiological conditions.…”

Section: Selenium In Foodmentioning

confidence: 99%

“…A level ranging between 10-550 mg kg À1 of Se (fresh wt) was reported in cereals, 10 whereas Se in bread is generally found at a level of B60-160 mg kg À1 . 9 Other vegetables such as those of the Allium family, including garlic and onion, can accumulate significant amounts of Se, reaching concentrations of Se up to 68 and 96 mg g À1 , respectively. 11 High amounts of Se can be accumulated also by mushrooms and broccoli.…”

Section: Selenium In Foodmentioning

confidence: 99%

“…In meat, eggs, and particularly fish, which are protein-rich, the Se content is relatively high, in the range of B49-739 mg kg À1 (fresh wt). 9 Additionally, specific organs, such as liver and kidney, may contain a particularly high concentration of Se, up to 1500 mg kg À1 . 9 A number of approaches can be used to estimate the dietary intake of Se, ranging from direct analysis of composite food types, to indirect calculation using dietary or market basket surveys and food composition tables.…”

Section: Selenium In Foodmentioning

confidence: 99%

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Selenium biochemistry and its role for human health

Roman¹,

Jitaru²,

Barbante³

2014

Metallomics

652

451

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Despite its very low level in humans, selenium plays an important and unique role among the (semi)metal trace essential elements because it is the only one for which incorporation into proteins is genetically encoded, as the constitutive part of the 21st amino acid, selenocysteine. Twenty-five selenoproteins have been identified so far in the human proteome. The biological functions of some of them are still unknown, whereas for others there is evidence for a role in antioxidant defence, redox state regulation and a wide variety of specific metabolic pathways. In relation to these functions, the selenoproteins emerged in recent years as possible biomarkers of several diseases such as diabetes and several forms of cancer. Comprehension of the selenium biochemical pathways under normal physiological conditions is therefore an important requisite to elucidate its preventing/therapeutic effect for human diseases. This review summarizes the most recent findings on the biochemistry of active selenium species in humans, and addresses the latest evidence on the link between selenium intake, selenoproteins functionality and beneficial health effects. Primary emphasis is given to the interpretation of biochemical mechanisms rather than epidemiological/observational data. In this context, the review includes the following sections: (1) brief introduction; (2) general nutritional aspects of selenium; (3) global view of selenium metabolic routes; (4) detailed characterization of all human selenoproteins; (5) detailed discussion of the relation between selenoproteins and a variety of human diseases.

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“…The total Se intake in some Se deficient areas of China is below 10 µg d -1 (5). To minimize the occurrence of health problems, such as cancer and cardiovascular and viral diseases, which can be induced by selenium deficiency (6), increasing the Se concentration in foods is an excellent means of Se supply to humans. Cereals as the major foodstuff may offer the best opportunity to do so (7).…”

Section: Introductionmentioning

confidence: 99%

Distribution and Translocation of Selenium from Soil to Grain and Its Speciation in Paddy Rice (Oryza sativa L.)

Sun

Liu

Williams

et al. 2010

Environ. Sci. Technol.

111

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Selenium, an essential micronutrient for humans, is insufficient in dietary intake for millions of people worldwide. Rice as the most popular staple food in the world is one of the dominant selenium (Se) sources for people. The distribution and translocation of Se from soil to grain were investigated in a Serich environment in this study. The Se levels in soils ranged widely from 0.5 to 47.7 mg kg -1 . Selenium concentration in rice bran was 1.94 times higher than that in corresponding polished rice. The total Se concentrations in the rice fractions were in the following order: straw > bran > whole grain > polished rice > husk. Significant linear relationships between different rice fractions were observed with each other, and Se in the soil has a linear relationship with different rice fractions as well. Se concentration in rice can easily be predicted by soil Se concentrations or any rice fractions and vice versa according to their linear relationships. In all rice samples for Se speciation, SeMet was the major Se species, followed by MeSeCys and SeCys. The average percentage for SeMet (82.9%) and MeSeCys (6.2%) was similar in the range of total Se from 2.2 to 8.4 mg kg -1 tested. The percentage of SeCys decreased from 6.3 to 2.8%, although its concentration elevated with the increase in total Se in rice. This could be due to the fact that SeCys is the precursor for the formation of other organic Se compounds. The information obtained may have considerable significance for assessing translocation and accumulation of Se in plant.

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Selenium in food and the human body: A review

Cited by 737 publications

References 155 publications

Antioxidant intake from diet and supplements and elevated serum C-reactive protein and plasma homocysteine concentrations in US adults: a cross-sectional study

Antioxidant intake from diet and supplements and elevated serum C-reactive protein and plasma homocysteine concentrations in US adults: a cross-sectional study

Selenium biochemistry and its role for human health

Distribution and Translocation of Selenium from Soil to Grain and Its Speciation in Paddy Rice (Oryza sativa L.)

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