Selenium in Ischemic Stroke

Skalny, Anatoly V.; Skalnaya, Margarita G.; Klimenko, L.L.; Mazilina, Aksana N.; Tinkov, Alexey A.

doi:10.1007/978-3-319-95390-8_11

Cited by 9 publications

(7 citation statements)

References 127 publications

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“…TEs are essential for maintaining human health due to their involvement in numerous signaling pathways and metabolic processes [ 5 ]. Some studies have shown that TE deficiencies in ischemic stroke occur more commonly than previously suspected [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

“…Selenium (Se) is an essential mineral that is critically involved in immunogenic, anticarcinogenic, and antimutagenic processes, including cell proliferation control and anti-aging activities. Se and many selenoproteins, as components of the antioxidant system, may exhibit neuroprotective properties [ 14 , 29 , 30 ]. The up-to-date human data have suggested that stroke is connected with considerably decreased Se levels, thus some studies have indicated the importance of preventing Se deficiencies in patients with risk factors for cardiovascular diseases, including ischemic stroke [ 14 , 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

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Selenium, Copper, Zinc Concentrations and Cu/Zn, Cu/Se Molar Ratios in the Serum of Patients with Acute Ischemic Stroke in Northeastern Poland—A New Insight into Stroke Pathophysiology

et al. 2021

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Background: In recent years, trace elements (TEs) have gained considerable attention in the course of treatment and diagnosis of ischemic stroke. The purpose of the conducted research was to determine the trace mineral status (Se, Cu, Zn, Cu/Zn ratio, and Cu/Se ratio) in patients with acute ischemic stroke compared to the population of healthy people in the northeastern region of Poland. Materials and methods: 141 patients with acute ischemic stroke (AIS) and 69 healthy control subjects were examined. The serum concentrations of mineral components were assessed by the atomic absorption spectrometry method. Clinical parameters were updated based on medical records. Results: The serum Se and Zn concentrations were significantly decreased (p < 0.0001; p < 0.0001) in patients with AIS compared with healthy control subjects. However, no significant differences were revealed in terms of the serum Cu concentration (p = 0.283). As expected, we found that the serum Cu/Zn and Cu/Se molar ratios were significantly higher (p = 0.001; p < 0.0001) in patients with AIS compared with healthy control subjects. Conclusions: Disturbed metal homeostasis is a significant contributor to AIS pathogenesis. Furthermore, marked disruption of the serum Cu/Zn and Cu/Se molar ratios could serve as a valuable indicator of AIS patients’ nutritional status and oxidative stress levels.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Selenium, Copper, Zinc Concentrations and Cu/Zn, Cu/Se Molar Ratios in the Serum of Patients with Acute Ischemic Stroke in Northeastern Poland—A New Insight into Stroke Pathophysiology

et al. 2021

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“…It has been noted that Se treatment restores ATP levels, hypothetically, by improvement of mitochondrial function. Se was shown to reduce caspase-3 activation and subsequent apoptosis under ischemic conditions, and decrease autophagy 32. It has been demonstrated that Se treatment prevents glutamate-induced neurotoxicity in HT22 neuronal cells,33 whereas Se deficiency increases susceptibility to glutamate excitotoxicity 34…”

Section: Discussionmentioning

confidence: 99%

“…Se was shown to reduce caspase-3 activation and subsequent apoptosis under ischemic conditions, and decrease autophagy. 32 It has been demonstrated that Se treatment prevents glutamate-induced neurotoxicity in HT22 neuronal cells, 33 whereas Se deficiency increases susceptibility to glutamate excitotoxicity. 34 In the clinical setting, early treatment with the oral administration of Ebselen (150 mg/bid), a seleno-organic substance with antioxidant activity via a GPx-like action, for 2 weeks has been linked to better neurological outcomes in patients with AIS.…”

Section: Discussionmentioning

confidence: 99%

Is Selenium Supplementation Beneficial in Acute Ischemic Stroke?

Ramezani

Simani

Abedi³

et al. 2021

The Neurologist

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Background: Selenium (Se) plays a significant role in brain physiology. The existing human data demonstrate that stroke is associated with significantly reduced Se levels and glutathione peroxidase (GPx) activity. This study proposed to investigate the effect of intravenous Se (Selenase) administration in patients with acute ischemic stroke (AIS) on neurological outcomes, antioxidant enzyme activity, and inflammatory marker levels. Methods: AIS patients (n=50) were recruited from a neurology unit of a university-affiliated hospital. Patients were randomly assigned to receive either Selenase or placebo (saline) for 5 days. The modified ranking scale, the national institute of health stroke scale, and the mini-mental state examination, as primary outcomes, and the serum GPx concentration, total antioxidant activity, and tumor necrosis factor-α levels, as secondary outcomes, were measured at the baseline and on day 30. Results: Eventually, 44 patients with AIS completed the intervention study. A notable increase in GPx and total antioxidant activity levels was detected in the treatment group compared with the placebo group (110.63±52.48 m/mL, 1.34±0.30 mmol/L, P<0.05), whereas the serum tumor necrosis factor-α level in the Selenase group was significantly lower than that of the placebo group (58.58±61.33 pg/mL, P<0.05). In addition, Selenase improved the modified ranking scale and national institute of health stroke scale scores significantly (P<0.05 and <0.04, respectively), but no statistical difference was observed between the 2 groups in the mini-mental state examination score. Conclusion: Selenase, plausibly due to its antioxidant function, results in positive outcomes in terms of neurological deficits, antioxidant enzyme activity, and inflammatory marker levels.

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“…Selenium supplementation at daily doses of 100-200 micrograms above RDA is necessary to prevent genetic damage and cancer development, so the use of a mixture composed of selenium, vitamins and minerals is a promising approach (El-Bayoumy, 2001). Supplementation even in individuals with recommended levels of selenium has pronounced immunostimulatory effects including increased T cell proliferation and natural killer cell activity (Wu et al, 2021;Rayman, 2000) and may provide a significant contribution to potential neuroprotective effects in stroke AVC; increases the activity of antioxidant enzymes, reducing the production of reactive oxygen species (ROS) and oxidative damage to macromolecules (Skalny et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Development of a prototype of a food supplement enriched with selenium based on fibers from the peel and pulp of Dipteryx alata Vogel (Baru)

Santos

Brandão²,

Paz³

et al. 2022

RSD

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Dipteryx alata, popularmente conhecido como “baruzeiro” é uma planta típica do Bioma Cerrado, com potencial nutricional da casca e polpa pouco explorado. O fruto D. alata, denominado “baru”, possui polpa fibrosa, que pode proporcionar redução no consumo alimentar aumentando o poder de saciedade e consequente redução da relação cintura-quadril, controlando a hipertensão arterial e melhorando o funcionamento intestinal. Sabe-se que o baru possui polpa fibrosa, e apesar dos benefícios que pode proporcionar como, redução do consumo alimentar pelo aumento do poder de saciedade e consequente redução da relação cintura-quadril, controle da hipertensão arterial e melhora do funcionamento intestinal. Grande parte da população tem ingestão de fibras abaixo do recomendado. Além da fibra, outro nutriente importante para a saúde é o selênio, dada a sua associação com alterações ou mau funcionamento do trato digestivo. O objetivo deste estudo foi desenvolver um protótipo de suplemento alimentar em sachês, elaborado a partir da casca e polpa de D. alata, que atenda às necessidades nutricionais diárias de fibra e selênio. Foram avaliados a qualidade microbiológica, composição centesimal, avaliação do estudo de estabilidade acelerada da casca e polpa de baru e o protótipo do suplemento. A matéria-prima estava adequada aos parâmetros de qualidade. O protótipo do suplemento se manteve estável, em relação ao perfil microbiológico, umidade, fibras, selênio e outros parâmetros. Dois sachês com 30 g de suplemento fornecem valor energético de 67,40 kcal, 1,56 g de proteína, 0,82 g de lipídios, 13,44 g de carboidratos, 9,42 g de fibra, 200,22 µg de selênio e outros micronutrientes. A formulação elaborada foi capaz de atender as recomendações para suplementos alimentares em relação à fibra alimentar e ao selênio, podendo ser utilizada para outros fins alimentícios, e ainda promover o aproveitamento de produtos ou subprodutos de frutos do Cerrado.

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Selenium in Ischemic Stroke

Cited by 9 publications

References 127 publications

Selenium, Copper, Zinc Concentrations and Cu/Zn, Cu/Se Molar Ratios in the Serum of Patients with Acute Ischemic Stroke in Northeastern Poland—A New Insight into Stroke Pathophysiology

Selenium, Copper, Zinc Concentrations and Cu/Zn, Cu/Se Molar Ratios in the Serum of Patients with Acute Ischemic Stroke in Northeastern Poland—A New Insight into Stroke Pathophysiology

Is Selenium Supplementation Beneficial in Acute Ischemic Stroke?

Development of a prototype of a food supplement enriched with selenium based on fibers from the peel and pulp of Dipteryx alata Vogel (Baru)

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