Selenium in placenta predicts birth weight in normal but not intrauterine growth restriction pregnancy

Klapec, Tomislav; Ćavar, Suzana; Kasač, Zoran; Ručević, Silvija; Popinjač, Ana

doi:10.1016/j.jtemb.2007.10.004

Cited by 46 publications

(32 citation statements)

References 27 publications

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“…This is on par with other investigations that found cord blood Se to be positively associated with birth weight (Klapec et al, 2008; Sun et al, 2014), and low maternal Se concentrations associated with low birth weight (Bogden et al, 2006), preterm birth (Rayman et al, 2011), and with increased odds and severity of PE (Rayman et al, 2003, 2014). These studies, like ours, highlight a potential role for Se in promoting successful pregnancies and protecting against fetal growth restriction.…”

Section: Discussionsupporting

confidence: 85%

“…Alternatively, many studies have found that maternal, fetal or placental Se concentrations positively correlate with fetal growth and successful pregnancies (Bogden et al, 2006; Klapec et al, 2008; Negi et al, 2012; Sun et al, 2014; Rayman et al, 2011, 2015, 2003). The adverse Cd-associated pregnancy and birth outcomes may be mitigated by concurrently higher levels of Se.…”

Section: Introductionmentioning

confidence: 99%

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Maternal exposure to selenium and cadmium, fetal growth, and placental expression of steroidogenic and apoptotic genes

Everson

Kappil

Hao

et al. 2017

Environmental Research

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Background Cadmium (Cd) and selenium (Se) antagonistically influence redox balance and apoptotic signaling, with Cd potentially promoting and Se inhibiting oxidative stress and apoptosis. Alterations to placental redox and apoptotic functions by maternal exposure to Cd and Se during pregnancy may explain some of the Cd and Se associations with fetal development. Objectives Investigate associations between Cd and Se concentrations in maternal toenails with placental expression patterns of tumor necrosis factor (TNF) and steroidogenic genes involved in redox reactions and test associations with fetal growth. Methods In a sub-sample from the Rhode Island Child Health Study (n = 173), we investigated the relationships between: (1) maternal toenail Cd and Se concentrations and fetal growth using logistic regression, (2) Cd and Se interactions with factor scores from placental TNF and steroidogenic expression patterns (RNAseq) using linear models, and (3) TNF and steroidogenic expression factors with fetal growth via analysis of covariance. Results Se was associated with decreased odds of intrauterine growth restriction (IUGR) (OR = 0.27, p-value = 0.045). Cd was associated with increased odds of IUGR (OR = 1.95, p-value = 0.13) and small for gestational age (SGA) births (OR = 1.46, p-value = 0.11), though not statistically significant. Cd and Se concentrations were antagonistically associated with placental TNF and steroidogenic expression patterns, which also differed by birth size. Conclusions Se may act as an antagonist to Cd and as a modifiable protective factor in fetal growth restriction, and these data suggest these effects may be due to associated variations in the regulation of genes involved in placental redox balance and/or apoptotic signaling.

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Maternal exposure to selenium and cadmium, fetal growth, and placental expression of steroidogenic and apoptotic genes

Everson

Kappil

Hao

et al. 2017

Environmental Research

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“…The efficiency of the placenta as a barrier against the passage of Cd might be modulated by maternal polymorphisms in genes that code for metal-binding metallothionein protein (Tekin et al 2011a). Most studies found no association between placental Cd and parity or maternal age (Frery et al 1993; Kantola et al 2000; Klapec et al 2008; Loiacono et al 1992; Roels et al 1978; Terrones-Saldivar et al 2008; Zadorozhnaja et al 2000), although in some cases higher levels were detected in older mothers (Al Saleh et al 2011; Fiala et al 1998). In another U.S. study, a higher Cd concentration was observed in multiparous women, albeit exclusively among smokers (Kuhnert et al 1988).…”

Section: Resultsmentioning

confidence: 99%

“…Indeed, 25 studies collected other complementary biologic specimens, such as maternal and umbilical cord blood, cord tissue, maternal milk, maternal or newborn hair and urine, or meconium. Finally, some researchers assessed the association between metal levels and disorders in the progress of pregnancy or newborn development, including premature membrane rupture or preterm births (Ahamed et al 2009; Baghurst et al 1991; Falcón et al 2003a); gestational age and anthropometric data (Ahamed et al 2009; Baghurst et al 1991; Falcón et al 2003a, 2003b; Frery et al 1993; Guo et al 2010; Kantola et al 2000; Khera et al 1980; Kippler et al 2010; Klapec et al 2008; Llanos and Ronco 2009; Loiacono et al 1992; Osada et al 2002; Pitkin et al 1976; Roels et al 1978; Ronco et al 2005a; Saxena et al 1994; Stasenko et al 2010; Tekin et al 2011a, 2011b; Wibberley et al 1977; Yang et al 1997; Zhang et al 2004); oligohydramnios (Terrones-Saldivar et al 2008); intrauterine growth restriction (IUGR) (Klapec et al 2008; Llanos and Ronco 2009; Osada et al 2002); Apgar score at birth (Zhang et al 2004); and fetal malformations or stillbirths (Baghurst et al 1991; Khera et al 1980; Saxena et al 1994; Scaal et al 1998; Wibberley et al 1977). …”

Section: Resultsmentioning

confidence: 99%

“…Studies assessing associations with risk factors generally furnished correlation coefficients drawn from univariate analyses, or differences in means derived from stratified analyses; few reports carried out multivariate analyses (Al Saleh et al 2011; Falcón et al 2002, 2003a, 2003b; Gundacker et al 2010; Kantola et al 2000; Kippler et al 2010; Klapec et al 2008; Lagerkvist et al 1996; Loiacono et al 1992; Osada et al 2002; Zhang et al 2004). …”

Section: Resultsmentioning

confidence: 99%

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Mercury, Cadmium, and Lead Levels in Human Placenta: A Systematic Review

Esteban-Vasallo¹,

Aragonés

Pollán

et al. 2012

Environ Health Perspect

156

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Background: Placental tissue may furnish information on the exposure of both mother and fetus. Mercury (Hg), cadmium (Cd), and lead (Pb) are toxicants of interest in pregnancy because they are associated with alterations in child development.Objectives: The aim of this study was to summarize the available information regarding total Hg, Cd, and Pb levels in human placenta and possible related factors.Methods: We performed a systematic search of PubMed/MEDLINE, EMBASE, Lilacs, OSH, and Web of Science for original papers on total Hg, Cd, or Pb levels in human placenta that were published in English or Spanish (1976–2011). Data on study design, population characteristics, collection and analysis of placenta specimens, and main results were extracted using a standardized form.Results: We found a total of 79 papers (73 different studies). Hg, Cd, and Pb levels were reported in 24, 46, and 46 studies, respectively. Most studies included small convenience samples of healthy pregnant women. Studies were heterogeneous regarding populations selected, processing of specimens, and presentation of results. Hg concentrations > 50 ng/g were found in China (Shanghai), Japan, and the Faroe Islands. Cd levels ranged from 1.2 ng/g to 53 ng/g and were highest in the United States, Japan, and Eastern Europe. Pb showed the greatest variability, with levels ranging from 1.18 ng/g in China (Shanghai) to 500 ng/g in a polluted area of Poland.Conclusion: The use of the placenta as a biomarker to assess heavy metals exposure is not properly developed because of heterogeneity among the studies. International standardized protocols are needed to enhance comparability and increase the usefulness of this promising tissue in biomonitoring studies.

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Concentrations of mercury (Hg) and selenium (Se) in afterbirth and their relations with various factors

Kosik-Bogacka

Łanocha-Arendarczyk

Kot

et al. 2018

Environ Geochem Health

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The aim of the study was to evaluate Hg and Se concentrations and Se:Hg molar ratios in the placenta, umbilical cord and fetal membranes, and to examine the relationship between the concentrations of the elements and selected factors. The study material consisted of the placenta, umbilical cord and fetal membranes obtained from 91 healthy women from northwestern and central Poland. In our study mean Hg and Se concentrations in afterbirth were ~ 0.01 mg/kg dry weight (dw) and ≤ 0.5 mg/kg dw, respectively. Correlation analysis showed negative relationships between placenta weight and Se concentration in the placenta and umbilical cord, as well as between placenta length and Se levels in the umbilical cord. We found negative correlations between THg concentration in the placenta and birth weight and between Se concentration in the placenta and umbilical cord and the morphological parameters of the placenta. Furthermore, we noted new types of interactions in specific parts of the afterbirth. In our study, Se:THg molar ratios ranged from 5 to 626; these values indicate protection against Hg toxicity.

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Selenium in placenta predicts birth weight in normal but not intrauterine growth restriction pregnancy

Cited by 46 publications

References 27 publications

Maternal exposure to selenium and cadmium, fetal growth, and placental expression of steroidogenic and apoptotic genes

Maternal exposure to selenium and cadmium, fetal growth, and placental expression of steroidogenic and apoptotic genes

Mercury, Cadmium, and Lead Levels in Human Placenta: A Systematic Review

Concentrations of mercury (Hg) and selenium (Se) in afterbirth and their relations with various factors

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