Selenium in serum as a possible parameter for assessment of breast disease

Kršnjavi, H.; Beker, D.

doi:10.1007/bf01806576

Cited by 13 publications

(2 citation statements)

References 21 publications

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“…Gupta et al (29) also found that plasma Se concentration was decreased in patients with breast cancer but that Se level decreased with the progress of disease. Similar results were found by Piccinnini et al (30) and Krsnjavi and Beker (31) . Willett et al (32) reported that low serum Se levels existed before the cancers developed, thereby increasing a person's risk of developing cancer.…”

Section: Discussionsupporting

confidence: 89%

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A comparative study of selenium concentration and glutathione peroxidase activity in normal and breast cancer patients

Moradi

Eftekhari

Talei

et al. 2009

Public Health Nutr.

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Objective: The present study was undertaken to compare plasma Se values and glutathione peroxidase (GPX) activity in normal and breast cancer patients. Design: In a case-control study, forty-five breast cancer patients and the same number of healthy women were randomly selected from their population. Se was measured in plasma by atomic absorption spectrophotometry and GPX activity in erythrocytes was measured using a standard spectrophotometric method. Results: Plasma Se concentration in healthy women and breast cancer patients was in the normal range, with no statistically significant difference observed between the two groups (138?40 (SD 40?36) mg/l v. 132?15 (SD 35?37) mg/l, respectively). Erythrocyte GPX activity was significantly (P , 0?01) higher in breast cancer patients (24?81 (SD 11?66) U/g Hb) compared with healthy women (20?29 (SD 4?24) U/g Hb).Conclusion: The present study indicated that Se deficiency was not a problem in the participants, and sufficient quantity of this element could increase GPX activity to have a protective effect against oxidative damage. Keywords Antioxidant Breast cancer Glutathione peroxidase SeleniumBreast cancer is the most common malignancy in women, with 1 million new cases worldwide each year, and comprises 18 % of female cancers (1) . In the Middle East, breast cancer is the most common malignancy among women (2) . Similarly in Iran, breast cancer is the highest in rank among cancers of women and accounts for 21?4 % of all malignancies in females (3) . There is evidence that Se as an essential trace element has anticancer properties (4)(5)(6)(7) . Research spanning the last 35 years has established that Se is effective in the reduction of cancer incidence when provided to animals at non-toxic dose (five to ten times the nutritional requirement) (8,9) . But for researchers conducting studies on Se and cancer prevention, the most exciting news in recent years has been the finding of Clark et al. (10) indicating that the supplementation of freeliving people with selenized brewer's yeast decreases overall cancer morbidity and mortality by nearly 50 %.Epidemiological data have also supported a protective effect of Se in man with regard to the prevention of both prostate cancer (11,12) and lung cancer (13) . The relationship between Se status and the incidence of breast cancer needs to be clarified, however, because one study indicates a protective effect (14) whereas other studies have not shown any protective effect (15)(16)(17)(18) . Cellular oxidative damage is a well-established general mechanism for cell and tissue injury. Oxidative damage to cells is caused primarily by free radicals and reactive oxygen species. Free radicals have the ability to bind to most normal cellular components; they react with unsaturated bonds of membrane lipids, denature proteins and attack nucleic acids. Prime targets of reactive oxygen species are the PUFA in cell membranes, causing lipid peroxidation which may lead to damage of cellular structure and function (19) . Oxidative stress...

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Section: Discussionsupporting

confidence: 89%

“…Similar results were found by Piccinnini et al . ( 30 ) and Krsnjavi and Beker ( 31 ) . Willett et al .…”

Section: Discussionmentioning

confidence: 97%

A comparative study of selenium concentration and glutathione peroxidase activity in normal and breast cancer patients

Moradi

Eftekhari

Talei

et al. 2009

Public Health Nutr.

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Serum Selenium Levels and Erythrocyte Glutathione Peroxidase Activity in Women with Breast Cancer

Brtková

Bella

Magálová

et al. 1996

Therapeutic Uses of Trace Elements

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Trace element correlations in the blood of indian women with breast cancer

Singh

Garg

1998

Biol Trace Elem Res

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Fourteen minor (Na, K, P, Fe) and trace (Br, Co, Cr, Cs, Hg, Rb, Sb, Se, Sr, Zn) elements have been determined in pre- and postoperative blood samples of 10 breast-cancer-affected. Indian women and compared with controls. The study showed elevation of Cr, Hg, Fe, Rb, Sb, and Zn and lowering of Se, K, P, and Sr contents in the blood of cancer patients. Most elemental contents in pre- and postoperative stages remain unaltered except Br, Co, and Sb. Statistical significance of Fe, Se, Zn, and Hg levels has been tested by box plots. Lowering of Se in blood (-54.4%) is correlated with its enhancement in cancerous breast tissue (94.7%) of various clinical stages. Se/Zn and Se/Fe ratios are lowered in the blood of cancer patients, whereas Na/K ratio is only marginally enhanced. An attempt has been made to correlate Se levels with the dietary intake and breast cancer risk vis-a-vis American and Japanese women.

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Selenium in serum as a possible parameter for assessment of breast disease

Cited by 13 publications

References 21 publications

A comparative study of selenium concentration and glutathione peroxidase activity in normal and breast cancer patients

A comparative study of selenium concentration and glutathione peroxidase activity in normal and breast cancer patients

Serum Selenium Levels and Erythrocyte Glutathione Peroxidase Activity in Women with Breast Cancer

Trace element correlations in the blood of indian women with breast cancer

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