Selenium-layered nanoparticles serving for oral delivery of phytomedicines with hypoglycemic activity to synergistically potentiate the antidiabetic effect

Abstract

Diabetes mellitus (DM) remains a great challenge in treatment due to pathological complexity. It has been proven that phytomedicines and natural medicines have prominent antidiabetic effects. This work aimed to develop selenium-layered nanoparticles (SeNPs) for oral delivery of mulberry leaf and Pueraria Lobata extracts (MPE), a group of phytomedicines with significant hypoglycemic activities, to achieve a synergic antidiabetic effect. MPE-loaded SeNPs (MPE-SeNPs) were prepared through a solvent diffusion/in situ reduction technique and characterized by particle size, ζ potential, morphology, entrapment efficiency (EE) and drug loading (DL). The resulting MPE-SeNPs were 120 nm around in particle size with EE of 89.38% for rutin and 90.59% for puerarin, two marker components in MPE. MPE-SeNPs exhibited a slow drug release and good physiological stability in the simulated digestive fluid. After oral administration, MPE-SeNPs produced significant hypoglycemic effects both in the normal and diabetic rats. Ex vivo intestinal imaging and cellular examinations demonstrated that MPE-SeNPs were provided with outstanding intestinal permeability and transepithelial transport aptness. It was also revealed that MPE-SeNPs could alleviate the oxidative stress, improve the pancreatic function, and promote the glucose utilization by adipocytes. Our study provides new insight into the use of integrative nanomedicine containing phytomedicines and selenium for DM treatment.

Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy

“…Several medicinal plants, such as Gymnema sylvestre, Momordica charantia, Azadirachta indica, Trigonella foenum gracecum, Tinospora cordifolia, Inula racemosa, Allium sativum, Eugenia jambolana, Syzygium cumini, Pterocarpus marsupium, Emblica officinalis, Asparagus racemosus, Boerhavia diffusa etc., have been reported to be clinically useful in the management of diabetes [349]. Green synthesis of herbal product-assembled polymeric or metallic nanoparticles has been found to achieve better therapeutic output in the management of diabetes than native crude products [351][352][353][354]. Phyto-nanotherapy offers better biopharmaceutical attributes and is revealed to be clinically equivalent to many commercially available antidiabetic drugs [353].…”

Nanopolyphenols: a review of their encapsulation and anti-diabetic effects

“…Both natural and synthetic polymers were used in the synthesis of the nanomaterials along with polymeric colloidal stabilizers. A few studies also incorporated inorganic species such as selenium and iron oxide into their matrix to assess for synergistic effects [67][68][69].…”

Nanodelivery of Natural Antioxidants: An Anti-aging Perspective

“…These mice demonstrated a substantial suppression of body weight gain as well as improved glucose tolerance and insulin sensitivity. Substantial hypoglycemic effect was also observed in both normal and diabetic rats administered with selenium-layered nanoparticles loaded with extracts of mulberry leaf and Pueraria lobata (Deng et al, 2019). These nanoparticles were also able to attenuate the oxidative damage, promote glucose utilization by adipocytes and enhance pancreatic function.…”