2019
DOI: 10.4103/ijpvm.ijpvm_45_18
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Selenium level in patients with heart failure versus normal individuals

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Cited by 19 publications
(10 citation statements)
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“…Older age, lower levels of albumin, worse kidney function, higher levels of NT-proBNP, and the presence of orthopnea and iron deficiency were established as independent predictors of selenium levels <100 μg/L in patients with worsening HF [ 20 ]. These observations are supported by similar findings in other small cohorts [ 32 35 ]. While these studies [ 7 , 32 35 ] focused mainly on HF with reduced ejection fraction (HFrEF), one small cohort-study aimed to compare selenium levels between HFrEF and HF with preserved ejection fraction (HFpEF) [ 36 ].…”
Section: Introductionsupporting
confidence: 91%
See 1 more Smart Citation
“…Older age, lower levels of albumin, worse kidney function, higher levels of NT-proBNP, and the presence of orthopnea and iron deficiency were established as independent predictors of selenium levels <100 μg/L in patients with worsening HF [ 20 ]. These observations are supported by similar findings in other small cohorts [ 32 35 ]. While these studies [ 7 , 32 35 ] focused mainly on HF with reduced ejection fraction (HFrEF), one small cohort-study aimed to compare selenium levels between HFrEF and HF with preserved ejection fraction (HFpEF) [ 36 ].…”
Section: Introductionsupporting
confidence: 91%
“…These observations are supported by similar findings in other small cohorts [ 32 35 ]. While these studies [ 7 , 32 35 ] focused mainly on HF with reduced ejection fraction (HFrEF), one small cohort-study aimed to compare selenium levels between HFrEF and HF with preserved ejection fraction (HFpEF) [ 36 ]. This study [ 36 ] showed that HFrEF patients have significantly lower selenium levels (HFrEF, 73.6 ± 7.5 μg/L) compared to those with HFpEF (77.7 ± 4.9 μg/L), but only selenium levels <90μg/L were reported in this study [ 36 ].…”
Section: Introductionsupporting
confidence: 91%
“…The important consideration is the possible benefit from Se homeostasis maintenance to improve the high prevalence of malnutrition and poor prognosis in patients with HF 21 . Although the decreased Se level was frequent in patients with HF compared to health controls 12 , 22 , 23 , the definitely correlation between this reduction and long-term survival was not well-established. Recently, an European multinational prospective cohort study revealed a 20.4% of Se deficiency among 2516 worsening HF patients, and found this deficiency in HF patients is independently associated with impaired exercise tolerance and a 50% higher mortality rate 13 .…”
Section: Discussionmentioning
confidence: 91%
“…Selenium deficiency may be crucial to maintaining stable hemodynamics in patients with a history of chronic heart failure and ischemic heart disease. Indeed, there have been several reports suggesting that selenium levels affect chronic heart failure or coronary heart disease ( 12 - 14 ). Another study showed the effects of selenium supplementation on reducing NT-proBNP levels and cardiovascular mortality ( 15 ).…”
Section: Discussionmentioning
confidence: 99%