Selenium levels, thiobarbituric acid-reactive substance concentrations and glutathione peroxidase activity in the blood of women with gestosis and imminent premature labour†

Gromadzińska, Jolanta; Wąsowicz, Wojciech; Rydzyński, K; Krasomski, Grzegorz; Broniarczyk, D; Andrijewski, Michal; Wołkanin, P

doi:10.1039/a705396g

Cited by 25 publications

(1 citation statement)

References 34 publications

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“…We used two types of RIA systems that we have developed (2). A RIA using antirat ghrelin N-terminal [1][2][3][4][5][6][7][8][9][10][11] measures the octanoylated active form of ghrelin. It was termed N-RIA.…”

Section: Authors' Response: N-octanoylated Ghrelin Levels Inmentioning

confidence: 99%

Low Vitamin B12 and Bone Loss: A Role for Folate Deficiency

Cagnacci

Cannoletta

Baldassari

et al. 2004

The Journal of Clinical Endocrinology &Amp; Metabolism

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aspect of medical care is important and relevant for endocrinologists. We also believe that screening guidelines should be derived based on published medical evidence in consideration of relevant social, legal, and economic applications. However, at present, we do not think there is a sufficient medical or legal basis to recommend calcitonin screening in all patients with thyroid nodule(s). We are grateful to Dr. Deftos for the letter (1) that gives us the opportunity to make some observations regarding routine measurement of serum calcitonin (Ct) in patients with thyroid nodule(s). In our opinion, there are several lines of evidence (reviewed in Refs. 2 and 3) that support the serum Ct measurement in association with fine-needle aspiration cytology (FNAC) as the most accurate tests for discovering medullary thyroid carcinoma (MTC). In addition, our experience on more than 10,000 patients demonstrates that when MTC is diagnosed by Ct screening, it has a better outcome likely due to the statistically significant lower stage of the disease at the diagnosis (2). Unfortunately, Hodak and Burman (3) could not discuss this issue because our paper was published just before their editorial. It is known that MTC is the most aggressive differentiated thyroid tumor, with a survival rate of 50% at 10 yr, and that the best prognostic factor is the stage of disease, with intrathyroidal tumors showing the best prognosis (4). The possibility of performing an early MTC diagnosis offered by the routine serum Ct measurement must be taken into account if we want to improve our capability to cure a disease that can be definitively cured only by the completeness of the initial surgical treatment. It is in fact well known that nowadays conventional chemotherapy and radiotherapy are ineffective to cure advanced MTC (5).Serum Ct measurement is a reliable test when performed in referral centers that have accurately defined their own cut-off values for basal and pentagastrin-stimulated Ct. A detailed description of the method and its practical usefulness is very well described in the "Laboratory Medicine Practice Guidelines for the Diagnosis and Monitoring of Thyroid Disease," recently published in the official journal of the American Thyroid Association and validated by a total of 84 independent reviewers from different countries (6).One of the main arguments against the routine use of serum Ct measurement is the possibility of false-positive tests, particularly when baseline values are between 10 and 100 pg/ml. This is not the real scenario when the test is strictly applied to patients with thyroid nodules but not to other benign thyroid disorders, such as Hashimotos' thyroiditis, where confounding factors still exist. In our experience in more than 10,000 patients, all presenting with thyroid nodule(s), false-positive results were very rare, and, rather than false positive, they were due to other well-known benign conditions associated with increased serum Ct concentrations, such as renal failure, that can be easily recognized by caref...

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Section: Authors' Response: N-octanoylated Ghrelin Levels Inmentioning

confidence: 99%

Low Vitamin B12 and Bone Loss: A Role for Folate Deficiency

Cagnacci

Cannoletta

Baldassari

et al. 2004

The Journal of Clinical Endocrinology &Amp; Metabolism

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Selenium supplementation during pregnancy for improving maternal and newborn outcomes

Bergamaschi

Mariath

Abbade

et al. 2012

Cochrane Database of Systematic Reviews

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A Prospective Study of Selenium Concentration and Risk of Preeclampsia in Pregnant Iranian Women: a Nested Case–Control Study

Ghaemi

Forouhari

Dabbaghmanesh

et al. 2013

Biol Trace Elem Res

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Preeclampsia remains a leading cause of maternal and perinatal mortality and morbidity worldwide; however, its specific etiology still remains obscure. Some studies implicate poor maternal selenium status predisposing the mother to preeclampsia. This study was designed to determine changes in plasma selenium levels in women having preeclampsia as compared with those with normal pregnancy. In a nested case-control study, 650 normal primigravida in their first 24-28 weeks participated in the study. After 3 months of follow-up of all subjects, blood selenium levels were measured in 38 women presenting consecutively with preeclampsia and in 38 women having a normal pregnancy by atomic absorption spectrophotometry. Birth outcomes were recorded, such as gestational age at delivery, height, weight, birth head circumflex and 1-min Apgar score. Preeclampsia affects about 5.84 % of pregnancies, and in our study, there were no significant differences in age, anthropometric indices, and family history of preeclampsia between the preeclamptic and control groups. The selenium concentrations in plasma in women with preeclampsia were significantly lower as compared with those in women with normal pregnancy (70.63 ± 21.41 versus 82.03 ± 15.54 μg/L, p < 0.05). Being in the bottom tertile of selenium concentration (less than 62.2 μg/L) was associated with greater risk of preeclampsia in pregnant women. The reduced selenium in the maternal circulations observed in the preeclamptic mothers support the hypothesis that insufficient selenium concentration may be a contributing factor to the pathophysiological mechanisms associated with preeclampsia, and optimizing the dietary selenium intake through supplementation could produce demonstrable clinical benefits.

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Selenium levels, thiobarbituric acid-reactive substance concentrations and glutathione peroxidase activity in the blood of women with gestosis and imminent premature labour†

Cited by 25 publications

References 34 publications

Low Vitamin B12 and Bone Loss: A Role for Folate Deficiency

Low Vitamin B12 and Bone Loss: A Role for Folate Deficiency

Selenium supplementation during pregnancy for improving maternal and newborn outcomes

A Prospective Study of Selenium Concentration and Risk of Preeclampsia in Pregnant Iranian Women: a Nested Case–Control Study

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