Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging

Leiter, Odette; Zhuo, Zhan; Rust, Ruslan; Wasielewska, Joanna M.; Grönnert, Lisa; Kowal, Susann; Overall, Rupert W.; Adusumilli, Vijay S.; Blackmore, Daniel G.; Southon, Adam; Ganio, Katherine; McDevitt, Christopher A.; Rund, Nicole; Brici, David; Mudiyan, Imesh Aththanayake; Sykes, Alex M.; Rünker, Annette E.; Zocher, Sara; Ayton, Scott; Bush, Ashley I.; Bartlett, Perry F.; Hou, Sheng T.; Kempermann, Gerd; Walker, Tara L.

doi:10.1016/j.cmet.2022.01.005

Cited by 97 publications

(80 citation statements)

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“…A novel study explored how proteins released in the bloodstream after exercise influence neurogeneration in the Dentate Gyrus of the hippocampus in mice [ 77 ]. Selenoptotein P, an antioxidant that is released into the blood after exercise, was shown to promote neurogenesis in both hippocampal stem cell cultures and in mice models.…”

Section: Discussionmentioning

confidence: 99%

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Brain Mapping the Effects of Chronic Aerobic Exercise in the Rat Brain Using FDG PET

Hanna

Hamilton

Arnavut

et al. 2022

JPM

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Exercise is a key component to health and wellness and is thought to play an important role in brain activity. Changes in brain activity after exercise have been observed through various neuroimaging techniques, such as functional magnetic resonance imaging (fMRI) and positron emission tomography (PET). The precise impact of exercise on brain glucose metabolism (BGluM) is still unclear; however, results from PET studies seem to indicate an increase in regional metabolism in areas related to cognition and memory, direction, drive, motor functions, perception, and somatosensory areas in humans. Using PET and the glucose analog [18F]-Fluorodeoxyglucose (18F-FDG), we assessed the changes in BGluM between sedentary and chronic exercise in rats. Chronic treadmill exercise treatment demonstrated a significant increase in BGluM activity in the following brain regions: the caudate putamen (striatum), external capsule, internal capsule, deep cerebellar white matter, primary auditory cortex, forceps major of the corpus callosum, postsubiculum, subiculum transition area, and the central nucleus of the inferior colliculus. These brain regions are functionally associated with auditory processing, memory, motor function, and motivated behavior. Therefore, chronic daily treadmill running in rats stimulates BGluM in distinct brain regions. This identified functional circuit provides a map of brain regions for future molecular assessment which will help us understand the biomarkers involved in specific brain regions following exercise training, as this is critical in exploring the therapeutic potential of exercise in the treatment of neurodegenerative disease, traumatic brain injury, and addiction.

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Section: Discussionmentioning

confidence: 99%

“…This protein triggers a cascade of activities, such as neurogenesis and proliferation, in the Dentate Gyrus of the hippocampus. Selenium increases via dietary supplementation and hippocampal infusion are coupled with greater spatial learning and improved memory [ 77 ].…”

Section: Discussionmentioning

confidence: 99%

Brain Mapping the Effects of Chronic Aerobic Exercise in the Rat Brain Using FDG PET

Hanna

Hamilton

Arnavut

et al. 2022

JPM

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“…In the mouse hippocampus, for example, exercise boosts neurogenesis. Leiter et al looked for proteins that increased in quantity when mice ran on a treadmill [ 1 ]. They report that increased levels of the selenium transport protein selenoprotein P (SEPP1) in the serum of exercised animals may contribute to the impact of exercise.…”

Section: Introductionmentioning

confidence: 99%

The Association Between Selenium, Selenoprotein P (SEPP1), Fluid Intelligence, and Exercise in the UK Biobank Cohort

Lehrer¹,

Rheinstein²

2022

Cureus

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Background: In the mouse hippocampus, exercise boosts neurogenesis. Increased levels of the selenium transport protein selenoprotein P (SEPP1) in the serum of exercised animals may contribute to the impact of exercise. SEPP1 is a protein that aids in the delivery of selenium to the brain. The effect of exercise on mouse brain precursor cell proliferation was diminished when SEPP1 or its receptor were genetically depleted. Selenium supplementation in the diet had the same effect as exercise in reducing some of the cognitive impairments associated with aging. Methods: In the current analysis, we sought to determine the association of selenium, the SEPP1 gene, fluid intelligence, and exercise in the UK Biobank Cohort. We analyzed SEPP1 single nucleotide polymorphism (SNP) rs7579, a single nucleotide variation (SNV), position chr5:42800706, C > T, minor allele frequency T = 0.281. Its consequence is a 3’- UTR variant. The 3′-UTR contains regulatory regions that post-transcriptionally influence gene expression and is responsible for selenoprotein synthesis. SNP rs7579 has been implicated in multiple forms of cancer. The univariate general linear model of SPSS (IBM Corp., Armonk, NY) was used to rule out the effects of age, years of education, and vigorous activity on fluid intelligence score, with fluid intelligence score as the dependent variable, rs7579 genotype, and selenium supplements as fixed factors, and age, years of education, and vigorous activity as covariates. Results: The effect of rs7579 genotype on fluid intelligence score was insignificant (p = 0.702). The effect of selenium supplements on fluid intelligence score was insignificant (p = 0.107). The interaction of rs7579 genotype and selenium supplements was insignificant (p = 0.911) and unrelated to the significant effects of age (p < 0.001), years of education (p < 0.001), and vigorous activity (p < 0.001) on fluid intelligence score. Conclusion: Our multivariate analysis of SEPP1 genotype, selenium supplement use, and fluid intelligence scores is consistent with the negligible effect selenium supplements seem to have on cognition. Selenium is found in nuts, dairy products, and grains. These foods can provide sufficient selenium for health. Selenium supplements are not recommended.

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“…For complete details on the use and execution of this protocol, please refer to Leiter et al. (2022) .…”

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confidence: 99%

“…These tests have been successfully used across multiple ages (from 2 to 24 months) in both wild-type and transgenic animals. For complete details on the use and execution of this protocol, please refer to Leiter et al. (2022) .…”

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confidence: 99%

Protocol for three alternative paradigms to test spatial learning and memory in mice

Blackmore¹,

Brici²,

Walker³

2022

STAR Protocols

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Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging

Cited by 97 publications

References 50 publications

Brain Mapping the Effects of Chronic Aerobic Exercise in the Rat Brain Using FDG PET

Brain Mapping the Effects of Chronic Aerobic Exercise in the Rat Brain Using FDG PET

The Association Between Selenium, Selenoprotein P (SEPP1), Fluid Intelligence, and Exercise in the UK Biobank Cohort

Protocol for three alternative paradigms to test spatial learning and memory in mice

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