Selenium nanoparticles are more efficient than sodium selenite in producing reactive oxygen species and hyper-accumulation of selenium nanoparticles in cancer cells generates potent therapeutic effects

Zhao, Guangshan; Wu, Ximing; Chen, Pingping; Zhang, Jinsong; Yang, Chung S.

doi:10.1016/j.freeradbiomed.2018.07.017

Cited by 106 publications

(89 citation statements)

References 47 publications

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“…SeNPs can also directly scavenge a flux of free radicals indicating that SeNPs belongs to redox‐active Se. We thus concluded that SeNPs is a potent antioxidant and has the capacity to enhance the antioxidant status of the cell and this was clarified by declining of MDA and elevating the antioxidant enzymes levels in the group that treated with combination of ACR and SeNps and this confirmed our hypothesis.…”

Section: Discussionmentioning

confidence: 99%

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Hypolipidemic and hepatoprotective synergistic effects of selenium nanoparticles and vitamin. E against acrylamide‐induced hepatic alterations in male albino mice

Hamza

Altalhi

Gobouri

et al. 2020

Applied Organom Chemis

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The potential benefit of selenium nanoparticles (SeNPs) and vitamin E (Vit.E) that they are potent antioxidants , they were used as antioxidants against acrylamide (ACR) hepatotoxicity, ACR is found in the starchy foods that had been heated for long periods in high degrees above 120°C. So the aim of the current study was to elucidate the antihyperlipidemic and hepatoprotective effects of either SeNPs and/or Vit.E against ACR toxicity, SeNPs were characterized by SEM, EDX, TEM and they proved their spherical nanostructure. Zeta potential value was –22.9 mv with particle size with a diameter range (48.75‐67.24 nm) which proved the high stability of the used SeNPs. Seven groups of male mice were used: group I was control,group II ACR,group III was treated with SeNPs, IV group was received Vit.E and groups V,VI received ACR plus SeNPs and ACR plus Vit.E, group VII was given combination of SeNPs and Vit.E plus ACR,So,The effect of SeNPs and/or Vit.E were monitored against ACR hepatotoxicity and hyperlipidemia. ACR administration afforded significant elevation in the hepatic enzymes with severe alterations in the lipid metabolism. These findings clarified the efficacy of SeNPs and Vit.E by declining the high hepatic enzymes activities induced by ACR along with improving the lipid profile, elevation of the antioxidant enzymes (SOD,CAT and GRx), reduction of MDA level, improving histological and ultrastructutral hepatic tissues and restoration of most normal structures that were damaged in ACR group. So, SeNPs and/or Vit.E were proved to enhance the hepatic antioxidant capacities.

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Section: Discussionmentioning

confidence: 99%

“…Selenium (Se) is a vital microelement . Selenium (Se) is a vital element; it is a vital element of glutathione peroxidase (An antioxidant enzyme) …”

Section: Introductionmentioning

confidence: 99%

Hypolipidemic and hepatoprotective synergistic effects of selenium nanoparticles and vitamin. E against acrylamide‐induced hepatic alterations in male albino mice

Hamza

Altalhi

Gobouri

et al. 2020

Applied Organom Chemis

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“…The specific microbicidal mechanisms of Se-NPs are still somewhat ambiguous, but several studies claimed that the production of reactive oxygen species (ROS) and free radicals is the main cause of bacterial cell destruction by Se organic compounds [41,46]. The microbicidal action of metallic NPs was due to their interaction with vital cellular components (RNA, DNA and ribosomes) to alter and deactivate their intracellular processes [47].…”

Section: Antibacterial Activity Of Npsmentioning

confidence: 99%

Phytosynthesis of selenium nanoparticles using the costus extract for bactericidal application against foodborne pathogens

Al-Saggaf

Tayel

Ghobashy

et al. 2020

Green Processing and Synthesis

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Selenium (Se) as a bioactive micronutrient could be augmented via transforming into nanoparticles (NPs), especially using biogenic protocols, for usage as an antimicrobial element. The reducing power of costus (Saussurea costus) root extract (SCE) was employed for phytosynthesis of Se-NPs through a simple and rapid protocol that included stirred mixing of 10 mM Na2SeO3 with 1.0% SCE solution for 4 h. The phytosynthesized SCE/Se-NP composite was obtained with a mean diameter of 6.13 nm and a zeta potential of −42.8 mV. Infrared analyses revealed the involvement of many SCE phytogroups in Se-NP synthesis, whereas transmission microscopy displayed well distribution and spherical shapes of the phytosynthesized NPs. The antibacterial assessments against foodborne pathogens (Escherichia coli, Salmonella typhimurium and Staphylococcus aureus) revealed the superior powers of SCE/Se-NPs and the elevated potentialities of SCE and Se-NPs for inhibition of bacterial pathogens. The scanning micrographs indicated that SCE/Se-NPs were attached to bacterial cells and led to their complete lysis/explosion with exposure prolongation. The SCE/Se-NP composites are recommended for the effective control of foodborne bacterial pathogens, applying a simple and eco-friendly phytosynthesis protocol.

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“…Hydrogen selenide, methylselenol, dimethylselenide and dimethyldiselenide are volatile small molecules and thus are likely to be found in the respiratory tract [ 147 , 153 , 154 ]. Some selenium compounds such as selenite and methylseleninic acid (a precursor of methylselenol) and many intermediates of selenium metabolism including selenodiglutathione, dimethyldiselenide and elemental selenium nanoparticles have strong redox activity [ 155 , 156 , 157 ]. A common property of these selenium species is that they undergo redox cycling in the thioredoxin system, composed of thioredoxin and TXNRD, and the glutaredoxin-coupled glutathione system composed of glutathione, glutathione reductase and glutaredoxin, with the formation of ROS with the sacrifice of NADPH [ 158 , 159 , 160 ] ( Figure 2 , low panel).…”

Section: Introductionmentioning

confidence: 99%

Selenium and selenoproteins in viral infection with potential relevance to COVID-19

et al. 2020

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Selenium is a trace element essential to human health largely because of its incorporation into selenoproteins that have a wide range of protective functions. Selenium has an ongoing history of reducing the incidence and severity of various viral infections; for example, a German study found selenium status to be significantly higher in serum samples from surviving than non-surviving COVID-19 patients. Furthermore, a significant, positive, linear association was found between the cure rate of Chinese patients with COVID-19 and regional selenium status. Moreover, the cure rate continued to rise beyond the selenium intake required to optimise selenoproteins, suggesting that selenoproteins are probably not the whole story. Nonetheless, the significantly reduced expression of a number of selenoproteins, including those involved in controlling ER stress, along with increased expression of IL-6 in SARS-CoV-2 infected cells in culture suggests a potential link between reduced selenoprotein expression and COVID-19-associated inflammation. In this comprehensive review, we describe the history of selenium in viral infections and then go on to assess the potential benefits of adequate and even supra-nutritional selenium status. We discuss the indispensable function of the selenoproteins in coordinating a successful immune response and follow by reviewing cytokine excess, a key mediator of morbidity and mortality in COVID-19, and its relationship to selenium status. We comment on the fact that the synthetic redox-active selenium compound, ebselen, has been found experimentally to be a strong inhibitor of the main SARS-CoV-2 protease that enables viral maturation within the host. That finding suggests that redox-active selenium species formed at high selenium intake might hypothetically inhibit SARS-CoV-2 proteases. We consider the tactics that SARS-CoV-2 could employ to evade an adequate host response by interfering with the human selenoprotein system. Recognition of the myriad mechanisms by which selenium might potentially benefit COVID-19 patients provides a rationale for randomised, controlled trials of selenium supplementation in SARS-CoV-2 infection.

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Selenium nanoparticles are more efficient than sodium selenite in producing reactive oxygen species and hyper-accumulation of selenium nanoparticles in cancer cells generates potent therapeutic effects

Cited by 106 publications

References 47 publications

Hypolipidemic and hepatoprotective synergistic effects of selenium nanoparticles and vitamin. E against acrylamide‐induced hepatic alterations in male albino mice

Hypolipidemic and hepatoprotective synergistic effects of selenium nanoparticles and vitamin. E against acrylamide‐induced hepatic alterations in male albino mice

Phytosynthesis of selenium nanoparticles using the costus extract for bactericidal application against foodborne pathogens

Selenium and selenoproteins in viral infection with potential relevance to COVID-19

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